Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
September 23, 2014, 04:41:46 AM

Login with username, password and session length


Members
  • Total Members: 23525
  • Latest: Dman
Stats
  • Total Posts: 639834
  • Total Topics: 48573
  • Online Today: 204
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online
Users: 0
Guests: 154
Total: 154

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Reyataz mono-therapy  (Read 1820 times)

0 Members and 1 Guest are viewing this topic.

Offline Pippet

  • Member
  • Posts: 135
  • Life is drawing without an eraser.
Reyataz mono-therapy
« on: February 07, 2007, 03:34:28 PM »
My doc made mention of Reyataz (400mg) being used as mono-therapy.  I was wondering if anyone has heard of this or tried it.
It just struck up my curiosity...

Take care.
Diagnosed Aug. 2006
CD4 246, VL 202,000
Started Truvada/ Viramune 11-23-06
Taken off meds 12-06-06 (Bad Rash)
Started Truvada/ Reyataz, Norvir 1-18-07
Taken off Norvir 3-1-07 (Jaundice)
New doc 3-22-07
CD4 229  VL 1031
My latest cocktail...  Truvada and Kaletra (4-6-07)
CD4 289 VL 350 (5-15-07)
CD4 308 VL 115 (8-06-07)
CD4 349 VL 511 (11-5-07)
CD4 489 VL 383 (2-4-08)
CD4 483 VL <50 (5-6-08) YEAH
CD4 545 VL 108 (9-12-08)
CD4 409 VL <48 (1-27-09) YEAH
CD4 505 VL <48 (5-20-09)
CD4 385 VL <48 (9-15-09)
CD4 609 VL  159 (2-28-10)

Offline gerry

  • Member
  • Posts: 522
  • Joined AM Feb 2003
Re: Reyataz mono-therapy
« Reply #1 on: February 07, 2007, 11:25:04 PM »
I believe there are a few preliminary Reyataz monotherapy studies but only with Norvir boost, and not in the unboosted form.

Offline trellium

  • Member
  • Posts: 95
  • stArk raving Borg
Re: Reyataz mono-therapy
« Reply #2 on: February 08, 2007, 01:01:57 AM »
Here's an article Pilot Study of Boosted Atazanavir Monotherapy Terminated Due to Virological Rebound

http://www.hivandhepatitis.com/recent/2007/012307_b.html

"Ritonavir-boosted atazanavir as maintenance monotherapy in HIV-1 infection might not be as potent as conventional [antiretroviral therapy]," the authors concluded, adding that, "Serum bilirubin should be further studied as a biomarker of adequate atazanavir exposure."


Offline newt

  • Member
  • Posts: 3,885
  • the one and original newt
Re: Reyataz mono-therapy
« Reply #3 on: February 08, 2007, 04:46:09 AM »
As with the Kaletra monotherapy studies, the nukes seem to be doing something and, while an interesting option to look at further, more studies are needed.

A few more

Atazanavir/r monotherapy and CNS penetration
1 out of 30 people here didn't stay undetectable.  Maybe importantly, central nervous system penetration of Reyataz (atazanavir) was not so good.

Simplification to atazanavir/ritonavir monotherapy
5 of 36 people here (counting drop-out as failure) had viral rebound

Resistance implications of monotherapy with lopinavir/r (Kaletra)
This is a report from the MONARK study, which randomised 136 people starting treatment for the first time with a viral load under 100,000 copies to either Kaletra monotherapy (83 people) or Kaletra+AZT+3TC (53), with follow-up for 96 weeks. A significantly greater percentage of patients receiving monotherapy had viral rebound or poor suppression: 21/83 vs 3/53 (25% vs 6%).

In all PI monotherapy studies, many people do well. But overall not as well as people on full combo. Reyataz may  not be potent enough to be a safe bet, although studies so far have all been small, so no firm conclusions can be drawn.  Kaletra, maybe, for people who have never used PIs, workable if they have perfect adherence and no baseline resistance. We need a big study really.  Already having an undetectable viral load for some months before going on a single boosted PI v starting on one is also probably also important to the outcome. Long term durability needs looking at too.

Pippet, your doc, while looking forward and being modern is one penny short of a silver dollar, if it is to be Reyataz monotherapy it needs to be (like gerry said) with a Norvir booster.

- matt
« Last Edit: February 08, 2007, 04:47:44 AM by newt »
"The object is to be a well patient, not a good patient"

Offline Pippet

  • Member
  • Posts: 135
  • Life is drawing without an eraser.
Re: Reyataz mono-therapy
« Reply #4 on: February 08, 2007, 12:33:40 PM »
Thanks for the links.  I was not considering this treatment.  I was just curious about what results they were having with it.

Quote
Pippet, your doc, while looking forward and being modern is one penny short of a silver dollar, if it is to be Reyataz monotherapy it needs to be (like gerry said) with a Norvir booster.
This statement is unfortunately very true.  I feel like I am treating myself, at times.  The funny part is that the mention of Reyataz monotherapy being in trial stages was during a conversation about my Jaundice. (obviously being caused by the Reyataz / Norvir).  I am just hoping the combo I am taking will suppress the virus so I can take the time needed to find another doc. (the ones taking new patients have a long waiting list)   I also found out that my ID doc's specialty is TB, not HIV.

 8)  *hiding my yellow eyes*
« Last Edit: February 08, 2007, 02:55:39 PM by Pippet »
Diagnosed Aug. 2006
CD4 246, VL 202,000
Started Truvada/ Viramune 11-23-06
Taken off meds 12-06-06 (Bad Rash)
Started Truvada/ Reyataz, Norvir 1-18-07
Taken off Norvir 3-1-07 (Jaundice)
New doc 3-22-07
CD4 229  VL 1031
My latest cocktail...  Truvada and Kaletra (4-6-07)
CD4 289 VL 350 (5-15-07)
CD4 308 VL 115 (8-06-07)
CD4 349 VL 511 (11-5-07)
CD4 489 VL 383 (2-4-08)
CD4 483 VL <50 (5-6-08) YEAH
CD4 545 VL 108 (9-12-08)
CD4 409 VL <48 (1-27-09) YEAH
CD4 505 VL <48 (5-20-09)
CD4 385 VL <48 (9-15-09)
CD4 609 VL  159 (2-28-10)

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.