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Author Topic: acetyl-cysteine incrses immune sys. HIV deplete cysteine destroys immune sys  (Read 2791 times)

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Offline bimazek

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  • Posts: 781
 N-acetyl-cysteine causes a marked increase in immunological functions and plasma albumin concentrations. The effect of N-acetyl-cysteine on the viral load, in contrast, was not consistent and may warrant further studies. Our findings suggest that the impairment of immunological functions in HIV+ patients results at least partly from cysteine deficiency. Because immune reconstitution is a widely accepted aim of HIV treatment, N-acetyl-cysteine treatment may be recommended for patients with and without ART. Our previous report on the massive loss of sulfur in HIV-infected subjects and the present demonstration of the immunoreconstituting effect of cysteine supplementation indicate that the HIV-induced cysteine depletion is a novel mechanism by which a virus destroys the immune defense of the host and escapes immune elimination.



 Improvement of immune functions in HIV infection by cysteine supplementation: Two randomized trials
Journal   Journal of Molecular Medicine
Publisher   Springer Berlin / Heidelberg
Thursday, February 19, 2004
   
Raoul Breitkreutz, Nicole Pittack, Carl Thomas Nebe, Dieter Schuster, Jürgen Brust, Matthias Beichert, Volker Hack, Volker Daniel, Lutz Edler, Wulf Dröge
Abstract

To determine the therapeutic effect of sulfur amino acid supplementation in HIV infection we randomized 40 patients with antiretroviral therapy (ART; study 1) and 29 patients without ART (study 2) to treatment for 7 months with N-acetyl-cysteine or placebo at an individually adjusted dose according to a defined scheme. The main outcome measures were the change in immunological parameters including natural killer (NK) cell and T cell functions and the viral load. Both studies showed consistently that N-acetyl-cysteine causes a marked increase in immunological functions and plasma albumin concentrations. The effect of N-acetyl-cysteine on the viral load, in contrast, was not consistent and may warrant further studies. Our findings suggest that the impairment of immunological functions in HIV+ patients results at least partly from cysteine deficiency. Because immune reconstitution is a widely accepted aim of HIV treatment, N-acetyl-cysteine treatment may be recommended for patients with and without ART. Our previous report on the massive loss of sulfur in HIV-infected subjects and the present demonstration of the immunoreconstituting effect of cysteine supplementation indicate that the HIV-induced cysteine depletion is a novel mechanism by which a virus destroys the immune defense of the host and escapes immune elimination.

Offline ajm_ldn

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  • Posts: 69
I take 1 gram each of NAC, acetyl-l-carnitine and l-glutamine twice per day on an empty stomach.  It seems to have kept me healthy for a long time, although I recently had to start meds after 9 years poz.  I plan to keep taking it and see if it helps my CD4s recover.  This protocol was recommended by my naturopath around 7-8 years ago.  Must say, I've never been sick other than the odd cold!

 


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