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Author Topic: 30+ AIDS Vaccine Clinical Trials In 24 Countries  (Read 1888 times)

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Offline trellium

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  • Posts: 95
  • stArk raving Borg
30+ AIDS Vaccine Clinical Trials In 24 Countries
« on: February 05, 2007, 02:14:30 AM »
30+ AIDS Vaccine Clinical Trials In 24 Countries, Research Occurring On Every Continent

http://www.medicalnewstoday.com/medicalnews.php?newsid=62206

The International AIDS Vaccine Initiative's (IAVI) January 2007 Annual Issue of VAX, an editorially independent bulletin on AIDS vaccine research published by IAVI, reports that 13 new preventive AIDS vaccine trials were initiated in eight countries around the world in 2006. There are now more than 30 trials ongoing in 24 countries, across every continent.

This annual publication provides the only comprehensive listing of all AIDS vaccine clinical trial activity worldwide.

Last year saw the start of the first AIDS vaccine trials in the Russian Federation and Zambia, and three countries in sub-Saharan Africa - Kenya, Uganda, and Tanzania - also initiated new trials. The United States, United Kingdom, Sweden and Peru began new trials in 2006 as well. Many of these trials were sponsored by new research groups, including the Karolinska Institute in Sweden, St. George's University of London and the Moscow Institute of Immunology.

All of the new trials that began last year were either Phase I or Phase I/II trials designed to evaluate the safety and immunogenicity of the candidate vaccines. "Although these new trials are early-stage, they will provide critical information over the coming years that will help drive the field's R&D agenda. We hope to begin to see even more novel vectors, as well as approaches that target neutralizing antibodies in the next few years," said CEO and President of IAVI, Dr. Seth Berkley.

IAVI and its collaborators are currently conducting four ongoing trials in India, Kenya, Rwanda, Uganda, South Africa and the United States. In 2006, IAVI launched a Phase II trial in Uganda and Zambia, part of a multi-site study that also included three sites in South Africa. The South Africa, Uganda and Zambia trial sites are now fully enrolled with data expected later this year.

Two of the most advanced trials underway in 2007 are from Sanofi-Pasteur and Merck & Co., Inc. Data from Merck's ongoing Phase IIb test-of-concept trial with its adeno-5 vector vaccine candidate is expected in 2008 or 2009 and will provide preliminary information on the efficacy of this type of vaccine candidate. These results will have significant implications for the field's future research and development efforts. The company will also soon be starting an additional Phase IIb trial with the same candidate in South Africa.

The Joint United Nations Programme on HIV/AIDS (UNAIDS) estimates that 4.3 million people were newly infected with HIV last year - bringing the total number of HIV-infected individuals to 40 million people worldwide. Explosive HIV epidemics also continue in Eastern Europe and Central Asia. Throughout the world, a preventive AIDS vaccine remains one of the greatest hopes for stemming the pandemic.



Comprehensive listing of all ongoing AIDS vaccine clinical trials as of Jan 2007

http://www.iavireport.org/vax/english/VAX_Jan07_Table.pdf



IAVI database of AIDS vaccines in human trials

http://www.iavireport.org/trialsdb/


Offline Ihavehope

  • Member
  • Posts: 1,366
  • Yes, I'm a cry baby, AND WHAT?
Re: 30+ AIDS Vaccine Clinical Trials In 24 Countries
« Reply #1 on: February 05, 2007, 09:53:49 AM »
I will say a prayer for all of us that these clinical trials are successful. For those who are running out of options for medications and for those of us who were newly diagnosed.
Infected: April 2005
12/6/06 - Diagnosed HIV positive
12/19/06 - CD4 = 240  22% VL = 26,300
1/4/07 - CD4 = 200 16% VL = ?
2/9/07 = Started Kaletra/Truvada
3/13/07 = CD4 = 386 22% VL ?

Offline J220

  • Member
  • Posts: 587
Re: 30+ AIDS Vaccine Clinical Trials In 24 Countries
« Reply #2 on: February 05, 2007, 07:15:12 PM »
Does the IAVI deal only in research for preventive vaccines? I am not clear- and too lazy to go looking at their website. Does anyone know if they are working n a threapeutic vaccine as well?
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

 


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