Meds, Mind, Body & Benefits > Questions About Treatment & Side Effects

Very disappointing 1st Labs - Should I be alarmed??

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jjmcm:
Hi Robert.

I agree with the other posts.  Your VL is a wash and remember your CD4's take a while to recover. It may take 2-3 months before you see a floor develop from where you are now.  I agree with your doctor on the first line of therapy.  It is very popular because of the limited side effects of Reyataz.

However, Reyataz, is by no means the strongest agent you have to use.  If you don't get the results you need, it could always be replaced with Kaletra or even Kaletra with Invirase.  I think you will find they both will make you undetectable in virtually no time.  And, it would likely stay that way for years.  Once your virus is snuffed down to undetectable, your CD4's will begin to rise.

BTW, make sure and not take any antacids in close proximity to the Reyataz or Proton Pump Inhibitors like Prilosec while on it.  It reduces the effectiveness.  My doctor didn't mention this at first, but I discovered it myself.  I want my meds to perform as well as possible.

Good luck,

--JJ

allopathicholistic:

--- Quote from: jjmcm on June 18, 2006, 11:07:56 AM ---make sure and not take any antacids in close proximity to the Reyataz or Proton Pump Inhibitors like Prilosec while on it. 

--- End quote ---

and if you ever have to take azithromycin a.k.a. zithromax, "Zmax", Sumamed - don't mix with antacids. 

newt:

--- Quote from: jjmcm on June 18, 2006, 11:07:56 AM ---However, Reyataz, is by no means the strongest agent you have to use.
--- End quote ---

96 week data showed Reyataz to be a least as good as Kaletra.

Atazanavir/ritonavir as potent over two years as Kaletra, but has better side-effects profile

- matt

doyourowndamndishes:
And I can vouch for Matt.  I was on Kaletra and Trizivir which really buggered up my entire lipid profile.  I switched Kaletra with Atazanavir + ritonavir boost.  It helped a bit but the ritonavir keep playing with the lipid profile as well.  Once I dropped the ritonavir, within 2 months the lipid profile (hdl, ldl, tryglicerides) all dropped well into the low normal/low healthy range.  Even my doctor was surprised at how quickly things leveled out.  Further, both he and I knew that this was due to Kaletra and not my diet or any other factors that I could control. 

Regarding the others advice, ya, it's the trends that really count.  If after 3 or 4 lab results you still have not reached "undetectable" you may want to talk to your doctor about genotype testing just to see if your particular strain of hiv already has some drug resistances.  Not only is the info invaluable it can also shed more light on which meds will still work for you so that you and your doctor can consider your next steps.

Good luck and let us know how you are doing!

Cheers,

Alan

BeachNYC:
Thanks for all the very very helpful comments.

I actually returned to my former doctor today (I just wasn't happy with the lack of info I was receiving from the new one), who was also puzzled by the failure to see any change, but not alarmed. He ordered up resistance testing, along with new labs. His thought was that either a) the blood test was screwed up, or b) I do indeed have some resistance that was not detected when the resistance test was originally done on me about 3 months ago.

Regardless, I am feeling much better about the whole thing, since my doctor assured me that even if this regimen DOESN'T work, and despite the fact that I apparently have resistance to all non-nukes, that there are still a host of possible regimens that I can use. That's really all I needed to hear....I needed some reassurance that if this fails, it doesn't mean that all regimens will also fail.

I will update this when I get my labs back, in about two weeks.

Meanwhile, thanks again for your very helpful advice.

Robert

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