Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
April 20, 2014, 11:58:04 AM

Login with username, password and session length


Members
Stats
  • Total Posts: 620497
  • Total Topics: 46752
  • Online Today: 221
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online
Users: 5
Guests: 179
Total: 184

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: valproic acid epilepsy hiv and viral Resevoirs  (Read 1865 times)

0 Members and 1 Guest are viewing this topic.

Offline bimazek

  • Member
  • Posts: 781
valproic acid epilepsy hiv and viral Resevoirs
« on: January 29, 2007, 07:07:29 PM »
i am newly diagnosised but i have personally met two long term survivors who had epilepsy and were taking valproic acid, perhaps this is what made them survive 25 years where others died... ask your dr.


HIV Breakthrough Study in US Raises Hopes for a Cure Finally
August 13th, 2005 by Angsuman Chakraborty

A cheap drug, enfurvitide, has shown promise in stamping out hidden pockets of HIV in three people who have long been infected with the virus.


    The result is described by the US scientists as merely a “proof of concept”, but has inevitably sparked talk of a cure for AIDS.

    HIV can already be kept in check by treatment with a powerful cocktail of drugs known as highly-active antiretroviral therapy (HAART). But the virus persists in a latent state in infected people.

    It is hoped that the new approach, developed by David Margolis and colleagues at the University of North Carolina at Chapel Hill, US, will finish off the virus in its latent hiding places.

    Four patients who had been on long-term HAART treatment were given a drug called enfurvitide twice daily for 4 to 6 weeks to intensify the effect of the HAART drugs. They were then given valproic acid, a drug which is usually used to treat epilepsy, twice daily for 3 months.

    Valproic acid inhibits an enzyme called histone deacetylase, which is known to help HIV linger in its dormant, hidden state. In 3 of the 4 patients, levels of latent HIV fell by 75%.

    “Our findings suggest that eradication of established HIV infection may be achieved in a staged approach,” says Margolis. “This finding, though not definitive, suggests that new approaches will allow the cure of HIV in the future.”

    Jean-Pierre Routy at McGill University Health Centre, Montreal, Canada, says that while the research is preliminary, the results merit urgent further study: “This is the first glimpse of a new therapeutic approach that might represent a possible step towards making HIV-infection no longer a chronic disease.”

Offline AustinWesley

  • Member
  • Posts: 815
    • HIV Discussion Group on Myspace!
Re: valproic acid epilepsy hiv and viral Resevoirs
« Reply #1 on: January 29, 2007, 07:16:52 PM »
Thanks for sharing this.   I just ran across this site on TheBody.com.

http://aidsinfo.nih.gov/DrugsNew/DrugDetailNT.aspx?MenuItem=Drugs&int_id=417&Search=Off&ClassID=6&TypeID=2

It sounds interesting although this site says it's not approved by the FDA yet for HIV treatment?   Some of the side effects were kind a scary, but Hell I'd try it.

Diag. 3/06  Infected aprx. 2 mo. Prior
Date        CD4   %      VL
4/6/06     627    32    36,500     NO MEDS YET!
6/7/06     409    27    36,100
8/23/06   408    25     22,300
1/2/07     354    23     28,700
2/9/07     139    30     23,000  Hep A Vaccine same day???
2/21/07   274    26     18,500 
3/3/07    RX of Truvada/Sustiva Started.
4/5/07    321     27      Undectable 1st mo.  
5/16/07  383     28    Undectable 2nd mo.
8/10/07  422     32   UD <48 on new scale!

Offline AustinWesley

  • Member
  • Posts: 815
    • HIV Discussion Group on Myspace!
Re: valproic acid epilepsy hiv and viral Resevoirs
« Reply #2 on: January 29, 2007, 07:22:44 PM »
You know I thought that name sounded familiar.  I've taken this drug before.   The brand name is Depakote and it was prescribed to me at one point for anxiety and depression years ago.  So apprently, it's used for epilepsy and seizures also.   

Well, is anyone out there already taking Depakote?   It's fairly commonly prescribed for bi polar and other mood disorders.   I'm now curious cause this drug has been around for a long time and lot of people take it.

Diag. 3/06  Infected aprx. 2 mo. Prior
Date        CD4   %      VL
4/6/06     627    32    36,500     NO MEDS YET!
6/7/06     409    27    36,100
8/23/06   408    25     22,300
1/2/07     354    23     28,700
2/9/07     139    30     23,000  Hep A Vaccine same day???
2/21/07   274    26     18,500 
3/3/07    RX of Truvada/Sustiva Started.
4/5/07    321     27      Undectable 1st mo.  
5/16/07  383     28    Undectable 2nd mo.
8/10/07  422     32   UD <48 on new scale!

Offline whizzer

  • Member
  • Posts: 363
Re: valproic acid epilepsy hiv and viral Resevoirs
« Reply #3 on: January 29, 2007, 09:40:26 PM »
There's a clinical trial currently recruiting at UNC-Chapel Hill regarding this.  David Margolis is the principal investigator.

Offline AustinWesley

  • Member
  • Posts: 815
    • HIV Discussion Group on Myspace!
Re: valproic acid epilepsy hiv and viral Resevoirs
« Reply #4 on: January 30, 2007, 07:19:14 PM »
Hey Whizzer,

I know someone else besides me interested.   He's on meds already.  I'm not, but probably will be soon.   Do you have a link to the clinical trial info?

Thanks,

Wesley
Diag. 3/06  Infected aprx. 2 mo. Prior
Date        CD4   %      VL
4/6/06     627    32    36,500     NO MEDS YET!
6/7/06     409    27    36,100
8/23/06   408    25     22,300
1/2/07     354    23     28,700
2/9/07     139    30     23,000  Hep A Vaccine same day???
2/21/07   274    26     18,500 
3/3/07    RX of Truvada/Sustiva Started.
4/5/07    321     27      Undectable 1st mo.  
5/16/07  383     28    Undectable 2nd mo.
8/10/07  422     32   UD <48 on new scale!

Offline trellium

  • Member
  • Posts: 95
  • stArk raving Borg
Re: valproic acid epilepsy hiv and viral Resevoirs
« Reply #5 on: January 31, 2007, 12:55:33 AM »
Hi Wesley,

here's the link to that clinical trial
"Inhibiting Histone Deacetylase: Towards Eradication of HIV"
http://clinicaltrials.gov/ct/show/NCT00312546?order=2

and another one
"Use of Valproic Acid to Purge HIV From Resting CD4+ Memory Cells/ A Proof-of-Concept Study"
http://clinicaltrials.gov/ct/show/NCT00289952?order=1


Offline AustinWesley

  • Member
  • Posts: 815
    • HIV Discussion Group on Myspace!
Re: valproic acid epilepsy hiv and viral Resevoirs
« Reply #6 on: January 31, 2007, 01:23:12 AM »
Thank you for those links!   YOU ROCK! ; )

I've posted those links in my own group to see if my friend might be interested.   I read the details and am not eligible because I'm not on meds and don't have an undectable VL.

Does sound interesting to me though.   Thank you!

Wesley
Diag. 3/06  Infected aprx. 2 mo. Prior
Date        CD4   %      VL
4/6/06     627    32    36,500     NO MEDS YET!
6/7/06     409    27    36,100
8/23/06   408    25     22,300
1/2/07     354    23     28,700
2/9/07     139    30     23,000  Hep A Vaccine same day???
2/21/07   274    26     18,500 
3/3/07    RX of Truvada/Sustiva Started.
4/5/07    321     27      Undectable 1st mo.  
5/16/07  383     28    Undectable 2nd mo.
8/10/07  422     32   UD <48 on new scale!

Offline madbrain

  • Member
  • Posts: 1,208
  • No longer an active member
    • My personal site
Re: valproic acid epilepsy hiv and viral Resevoirs
« Reply #7 on: February 07, 2007, 08:42:43 PM »
Unfortunately, Depakote doesn't seem to be the cure after all :
http://www.aidsmeds.com/articles/1667_11202.shtml

I have taken Depakote for bipolar disorder before and it made me nauseate and puke, especially if I had any amount alcohol during the same day that I took it. I was switched to Tegretol instead.

Offline AustinWesley

  • Member
  • Posts: 815
    • HIV Discussion Group on Myspace!
Re: valproic acid epilepsy hiv and viral Resevoirs
« Reply #8 on: February 07, 2007, 11:40:08 PM »
Hey Mad,

I read that article and feel the title of it was poorly chosen.   I'd never felt this was any kind of cure, but that article had a very negative slant starting with the headline.   

I think the author worded it poorly top to bottom because although the results aren't any kind of cure they do seem promising and worth researching further.

Made me wonder what the author's motivation was for the article.

Wesley
Diag. 3/06  Infected aprx. 2 mo. Prior
Date        CD4   %      VL
4/6/06     627    32    36,500     NO MEDS YET!
6/7/06     409    27    36,100
8/23/06   408    25     22,300
1/2/07     354    23     28,700
2/9/07     139    30     23,000  Hep A Vaccine same day???
2/21/07   274    26     18,500 
3/3/07    RX of Truvada/Sustiva Started.
4/5/07    321     27      Undectable 1st mo.  
5/16/07  383     28    Undectable 2nd mo.
8/10/07  422     32   UD <48 on new scale!

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.