Quantcast

Subscribe to:
POZ magazine
Newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr Instagram
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
December 28, 2014, 06:03:17 AM

Login with username, password and session length


Members
  • Total Members: 24314
  • Latest: Eb39
Stats
  • Total Posts: 650567
  • Total Topics: 49675
  • Online Today: 146
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online
Users: 5
Guests: 131
Total: 136

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: 2% of CD4s in blood, 98% in mucosal tissues vagina, airways, esp. the gut  (Read 2960 times)

0 Members and 1 Guest are viewing this topic.

Offline bimazek

  • Member
  • Posts: 781
New research suggests HIV treatment focus on guts
www.chinaview.cn 2006-12-17 04:29:14

    LONDON, Dec. 16 (Xinhua) -- HIV deals a body blow to the immune system almost immediately after infection by destroying key cells in the gut lining, new research findings show.

    HIV attacks CD4 cells, known as "helper" T-cells, which help coordinate immune responses. In the blood of infected people, there is a steady fight between viral replication and the production of new CD4 cells to replace those that are lost to the virus. If left untreated, HIV eventually wins this battle, and the immune system collapses.

    New research have shown that only about 2 percent of CD4 cells circulate in the blood, and the vast majority of CD4 cells, some 98 percent, are in mucosal tissues, such as those lining the vagina, airways and especially the gut - possibly because pathogens typically enter the body through such tissues, according to the latest issue of the New Scientist published on Saturday.

    The number of CD4 cells in the gut lining plummets by up to 60 percent within the first few weeks of infection.

    Researchers led by Martin Markowitz of the Aaron Diamond AIDS Research Center in New York are picking apart the mechanisms by which HIV wreaks havoc in the gut, the report said.

    The virus not only kills gut CD4 cells directly but also gets the immune system to turn on itself: some CD4 cells self-destruct and others seem to be killed by other T-cells, which the researchers believe is linked to the way HIV activates the immune system abnormally.

    This may explain why highly active anti-retroviral therapy (HAART), most successful treatment for HIV now, does not fix all the damage that HIV causes, even in people who are treated very early after being infected.

    The virus hits immune cells in mucosal tissues hard and fast, usually before treatment with HAART even starts. Despite being put on drugs within about three weeks, 70 percent of Markowitz's patients lost more than half of the CD4 cells in their lower gut, the report said.

    The damage may also trigger further harmful immune activation throughout the body, said Daniel Douek at the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, whose work suggests that damage to the gut enables molecules including lipopolysaccharides which are a component of bacterial cell walls and stimulate the immune system, from microbes in the gut to enter the bloodstream, the New Scientist said

laymens point of view...

questions
does this mean that on haart, hiv is 49 times more active in the gut than in the blood?
what treatments are possible for the chronic inflamation of gut mucosal tissue that is infected even on haart?
does taking an anti inflamitory as suggested at end of article about gut being prductively infected make sense? would it help in any way?
since the gut lining replaces itself very fast, every 3 days?, is it possible that that is why there are so much diarehha even on haart?
why doesnt haart penetrate the gut mucosal tissue and stop virus rep. there? 





Offline lostboy

  • Member
  • Posts: 67
I guess we're all screwed then!  :-[

There seems to be so much they don't know about this disease, it is lucky that they have stumbled upon some medications, but according to this, the treatments are not even targeting the bulk of the infection.
"There is no gene for the human spirit"

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.