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Author Topic: New Mutation!!  (Read 9260 times)

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Offline pozguy75

  • Member
  • Posts: 1,239
    • POZitively Speaking
New Mutation!!
« on: January 07, 2007, 11:30:59 PM »
Well, I just got my latest genotype back...and come to find out my little HIV darlings have mutated and I am now resistant to Combivir! I have to make yet another med switch, this makes two in one month! Yuck! Oh well...we will see...
Dx 2005
ATRIPLA

Offline thunter34

  • Member
  • Posts: 7,318
  • His name is Carl.
Re: New Mutation!!
« Reply #1 on: January 07, 2007, 11:32:48 PM »
I'm sorry tp hear that, doll.  That sucks.
AIDS isn't for sissies.

Offline koi1

  • Member
  • Posts: 713
Re: New Mutation!!
« Reply #2 on: January 08, 2007, 12:10:40 AM »
Hey,

Sorry to hear about that. Did the doc have any idea why this happened? I hope they will find a kickass combo for you soon.

rob
diagnosed on 11/20/06 viral load 23,000  cd4 97    8%
01/04/07 six weeks after diagnosis vl 53,000 cd4 cd4 70    6%
Began sustiva truvada 01/04/07
newest labs  drawn on 01/15/07  vl 1,100    cd4 119    7%
Drawn 02/10/07
cd4=160 viral load= 131 percentage= 8%
New labs 3/10/07 (two months on sustiva truvada
cd4 count 292  percentage 14 viral load undetectable

Offline Blixer

  • Member
  • Posts: 712
Re: New Mutation!!
« Reply #3 on: January 08, 2007, 12:13:09 AM »
Sorry to hear about the resistance.  Hope your doc comes up with a combo that is easy on you but gives heck to the virus.
David
Diagnosed 1/9/06
8/27/2007 CD4 598, 29%, VL 58 (72 wks)
11/19/2007 CD4 609, 30%, VL < 50 (84 wks)
2/11/2008 CD4 439, 27%, VL <50 (96 wks)
5/5/2008 CD4 535, 28%, VL <50 (108 wks)
10/20/2008 CD4 680, 28%, VL <50 (132 wks)
Changed to Atripla in 2012
1/14/2013 CD4 855, 35%, VL <40

Offline lydgate

  • Member
  • Posts: 1,022
  • Virgin, can't drive
Re: New Mutation!!
« Reply #4 on: January 08, 2007, 12:20:17 AM »
Sorry to hear about this bud. Two med switches in a month, that's rough. Are you resistant to both AZT as well as 3TC? I'm pretty sure you'll get expert suggestions from people here. And you seem to have an amazing pragmatic attitude, which rawks. (I learn new words from Ameds every day  ;D )
Her finely-touched spirit had still its fine issues, though they were not widely visible. Her full nature, like that river of which Cyrus broke the strength, spent itself in channels which had no great name on the earth. But the effect of her being on those around her was incalculably diffusive: for the growing good of the world is partly dependent on unhistoric acts; and that things are not so ill with you and me as they might have been, is half owing to the number who lived faithfully a hidden life, and rest in unvisited tombs.

George Eliot, Middlemarch, final paragraph

Offline skeebo1969

  • Member
  • Posts: 5,707
Re: New Mutation!!
« Reply #5 on: January 08, 2007, 12:27:00 AM »


  Damn Jer sorry to hear this..   
I despise the song Love is in the Air, you should too.

Offline cubbybear

  • Member
  • Posts: 510
  • Joined August 2005.
Re: New Mutation!!
« Reply #6 on: January 08, 2007, 12:35:33 AM »
Hey Sexy,

Bugger about the resistance.  Here's to the next combo kicking hiv butt.  Keep us up to date, I'm sure you will.

Love ya guts.
Matt
There's a bear in there!
Positive since 2000
Diagnosed 17/9/2005 CD4 35 VL 293,000
Meds 23/9/2005 Sustiva/Truvada
Currently CD4 232 VL Undetectable

Offline Queen Tokelove

  • Member
  • Posts: 6,033
  • Smokey the Smurf
Re: New Mutation!!
« Reply #7 on: January 08, 2007, 01:54:54 AM »
Sorry to hear about the resistance, sweetie...I'm sure they will come up with something that will help you make a comeback. Stay strong!
Started Atripla/Ziagen on 9/13/07.
10/31/07 CD4-265 VL- undetectable
2/6/08 CD4- 401 VL- undetectable
5/7/08 CD4- 705 VL- undetectable
6/4/08 CD4- 775 VL- undetectable
8/6/08 CD4- 805 VL- undetectable
11/13/08 CD4- 774 VL--undetectable
2/4/09  CD4- 484  VL- 18,000 (2 months off meds)
3/3/09---Starting Back on Meds---
4/27/09 CD4- 664 VL-- undetectable
6/17/09 CD4- 438 VL- 439
8/09 CD4- 404 VL- 1,600
01-22-10-- CD4- 525 VL- 59,000
Cherish the simple things life has to offer

The Royal Blog

Offline Eldon

  • Member
  • Posts: 2,664
Re: New Mutation!!
« Reply #8 on: January 08, 2007, 01:58:24 AM »


Hey Jeromy,

Sorry to hear the news about your mutation. I send you my best wishes for the best possible outcome.





"What can I notice right now that makes me smile?"

Offline pozguy75

  • Member
  • Posts: 1,239
    • POZitively Speaking
Re: New Mutation!!
« Reply #9 on: January 08, 2007, 10:12:16 AM »
Yep, it appears that I have a resistence with both AZT and 3TC...SUCKS!! So, I am still good with Kaletra, so hopefully I won't have to switch up everything!

Calling the doc today...
Dx 2005
ATRIPLA

Offline Iggy

  • Member
  • Posts: 2,435
Re: New Mutation!!
« Reply #10 on: January 08, 2007, 10:20:26 AM »
.
« Last Edit: January 09, 2007, 11:02:53 PM by Iggy »

Offline aztecan

  • Member
  • Posts: 5,414
  • 29 years positive, 57 years a pain in the butt
Re: New Mutation!!
« Reply #11 on: January 08, 2007, 10:22:43 AM »
Hey Jeromy,

Does your GART show whether you are resistant to all NRTI's? Just askin . . .

I hope whatever you switch to kicks butt.

BIG HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline Catman

  • Member
  • Posts: 419
  • Blessed with more than 9 lives! + since 1986
    • Who is the Catman?
Re: New Mutation!!
« Reply #12 on: January 08, 2007, 10:37:50 AM »
Check with your doctor if it's time to begin with Fuzeon. It has been the only med to get me undetectable in 20 years and I am also resistant to everything else till last year. Let's see if 2007 brings the new meds people are talking about. I'm sending you a private email now so check it out later... :(
Catman

Meow to the birds
Meow to the tree's
Meow to the end
of this dreadful disease...

Offline GSOgymrat

  • Member
  • Posts: 5,047
  • HIV+ since 1993. INTJ
Re: New Mutation!!
« Reply #13 on: January 08, 2007, 10:39:32 AM »
How reliable are those genotype tests? I'm skeptical, not about your case but the test in general.

Offline pozguy75

  • Member
  • Posts: 1,239
    • POZitively Speaking
Re: New Mutation!!
« Reply #14 on: January 08, 2007, 10:42:37 AM »
Hey Jeromy,

Does your GART show whether you are resistant to all NRTI's? Just askin . . .

I hope whatever you switch to kicks butt.

BIG HUGS,

Mark



Nope just the Combivir at this point...
Dx 2005
ATRIPLA

Offline allopathicholistic

  • Member
  • Posts: 3,258
Re: New Mutation!!
« Reply #15 on: January 08, 2007, 10:50:42 AM »
How reliable are those genotype tests? I'm skeptical, not about your case but the test in general.

Hear hear. Good reminder that we pozzies have the right to question everything

Offline J220

  • Member
  • Posts: 587
Re: New Mutation!!
« Reply #16 on: January 08, 2007, 11:10:30 AM »
Regarding the genotype tests, coincidentally I just read over at the research forum that there is a report of a new hiv test with " a level of sensitivity that makes the assay about 1,000 times more sensitive than the most widely used assays on the market for detecting drug-resistant HIV viruses".

http://forums.poz.com/index.php?topic=7587.0

Seems they are ready to patent the test, so once that is done, it could be before the end of the year, maybe even mid-year that this test could be available. Sound like a great tool.

Not sure if this is something that helps you now, but maybe you can contact Duk Universtiy and see if you can "volunteer" for the test. You never know!
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline Christine

  • Member
  • Posts: 1,069
Re: New Mutation!!
« Reply #17 on: January 08, 2007, 11:12:31 AM »
Damn mutations...And another med switch...

Sending good thoughts and hugs your way that things improve!
Christine
Poz since '93. Currently on Procrit, Azithromax, Pentamidine, Valcyte, Levothyroxine, Zoloft, Epzicom, Prezista, Viread, Norvir, and GS-9137 study drug. As needed: Trazodone, Atavan, Diflucan, Zofran, Hydrocodone, Octreotide

5/30/07 t-cells 9; vl 275,000

Offline LatinAlexander

  • Member
  • Posts: 599
  • Bogota, Colombia
Re: New Mutation!!
« Reply #18 on: January 08, 2007, 11:55:41 AM »
With you in my thoughts boy!

Alex
Poz since Jul 19 2006
Initial numbers : CD4-250 VL 3500
First labs after HAART (Dec 04-2006) : CD4-432 VL-<40 (Undetectable)  cd4%=25.11%
Started HAART: Combivir+Efavirenz Aug 26 7:38 pm
Feb 08 2007 - Gradually stopping HAART cause of Myalgia. Protecting Efavirenz. Stopped Efavirenz, ahead with Combivir....
February 17 Combivir stopped.
April 3 -07 : Started ddi+3tc+efavirenz...
Gay and positive (What a lack of Identity...:) )
Looking for my Ben....

Offline Longislander

  • Member
  • Posts: 2,486
Re: New Mutation!!
« Reply #19 on: January 08, 2007, 01:05:02 PM »
Sorry to hear this buddy, keep up the good attitude. Hope the next is a winner!
infected 10/05 diagnosed 12-05
2/06   379/57000                    6/07 372/30500 25%   4/09 640/U/32% 
5/06   ?? /37000                     8/07 491/55000/24%    9/09 913/U/39%
8/06   349/9500 25%              11/07 515/68000/24     2/10 845/U/38%
9/06   507/16,000 30% !          2/08  516/116k/22%    7/10 906/80/39%
12/06 398/29000 26%             Start Atripla 3/08
3/07   402/80,000 29%            4/08  485/undet!/27
4/07   507/35,000 25%            7/08 625/UD/34%
                                                 11/08 684/U/36%

Offline Life

  • Member
  • Posts: 2,388
  • Member 2005
Re: New Mutation!!
« Reply #20 on: January 08, 2007, 01:17:03 PM »
Jeromy, I am sorry to here this but hopeful your doctor finds the puzzle fix... Jeromy did you have a resistant virus to begin with?  I was under the impression you have been on meds for not a very long time..

We are thinking about you...

Offline budndallastx

  • Member
  • Posts: 463
Re: New Mutation!!
« Reply #21 on: January 08, 2007, 01:49:10 PM »
Wishing you the best and hope the next combo is the one !

Tom
Meds since: 11/20/2006
Sustiva / Truvada
12/08/2008 VL:<48 CD4 622 (38%)   
9/8/2008 VL:<48 CD4 573 (30%)
5/2008 VL:<48 CD4 464 (30%)
1/2008  VL: <50  CD4 425(28%)
9/2007   VL: <50  CD4 465 (27%)
6/2007   VL: <50   CD4 443 (26%)
3/2007  VL: <50   CD4 385 (25%)
12/2006 - VL: <50   CD4: 384 (25%)
11/2006 - VL:  22K  CD4: 208 (18%)

Offline Boo Radley

  • Member
  • Posts: 1,252
  • Not a "real man" and damn proud, mithter... FAB
    • Animal Rescue New Orleans
Re: New Mutation!!
« Reply #22 on: January 08, 2007, 03:41:23 PM »
That is a drag about the resistance but your numbers look pretty good so surely you'll find the next combo works like a charm and has NO side effects!!  I can hope, can't I?

Good luck Jeromy!

Boo
String up every aristocrat!
Out with the priests and let them live on their fat!





Everything I do, say, think, excrete, secrete, exude, ooze, or write 2007 Sweet Old Boo, Inc.

Offline poet

  • Member
  • Posts: 934
  • Poet living and working in Central Maine
Re: New Mutation!!
« Reply #23 on: January 08, 2007, 03:58:19 PM »
Hey Jeromy, sorry like everyone else to hear about your resistance problem.  One good thought which came to me is that given the two drugs involved, it may be how old and so passed around they are, rather than your virus somehow cleverly working around a brand new one/type.  With fingers crossed for a quick resolution, Win
Winthrop Smith has published three collections of poetry: Ghetto: From The First Five; The Weigh-In: Collected Poems; Skin Check: New York Poems.  The last was published in December 2006.  He has a work-in-progress underway titled Starting Positions.

Offline woodshere

  • Member
  • Posts: 1,477
  • ain't no shame in my game
Re: New Mutation!!
« Reply #24 on: January 08, 2007, 04:06:48 PM »
Jeromy,  Sorry to hear the news, hopefully your next combo will have as positive an affect for you as your great attitude, wit and devilish demeanor has for all of us on these forums!

Cheers,
Woods
"Let us give pubicity to HV/AIDS and not hide it..." "One of the things destroying people with AIDS is the stigma we attach to it."   Nelson Mandela

Offline newt

  • Member
  • Posts: 3,887
  • the one and original newt
Re: New Mutation!!
« Reply #25 on: January 08, 2007, 07:34:05 PM »
Bad luck

(and, erm, which mutations exactly?)

- matt
"The object is to be a well patient, not a good patient"

Offline aupointillimite

  • Member
  • Posts: 3,229
  • FUS DO RAH!
Re: New Mutation!!
« Reply #26 on: January 08, 2007, 08:12:10 PM »

Nope just the Combivir at this point...

Thank bloody God!

I was worried you ran out of all your nukes...

I'm glad that you haven't, dude... I hope it turns out OK.
Your tastebuds can't repel flavor of this magnitude!

Offline SoSadTooBad

  • Member
  • Posts: 248
Re: New Mutation!!
« Reply #27 on: January 08, 2007, 09:05:48 PM »
Sending good thoughts your way... 

sstb

Offline Jody

  • Member
  • Posts: 1,840
Re: New Mutation!!
« Reply #28 on: January 08, 2007, 09:34:53 PM »
Jeromy...Sorry to hear the news about twice in one month getting these results...Hope you find a combo that suits you well.  Keep us posted.

Jody
"Wake up to find out that you are the eyes of the world".
 "Try to discover that you are the song that the morning brings."

Grateful Dead

Offline Nadine

  • Member
  • Posts: 1,253
  • Member since: August 2005
Re: New Mutation!!
« Reply #29 on: January 08, 2007, 09:37:59 PM »
Wishing you the best Jeromy!

Offline mrtallguy

  • Member
  • Posts: 199
Re: New Mutation!!
« Reply #30 on: January 08, 2007, 10:08:19 PM »
Jeromy....There is a great light that shines from you....your smile is more infectious than any disease known to man!  So with these powers of light this moment of darkness will not last!  Remember that the sun shines every day....although the clouds  would have us believe otherwise!  Do not put power in the clouds my friend for your LIGHT will prevail!!

Be Well, Good Luck, Hugs, and.... :-*...okay I'll stop there.....for now!

Craig
I AM DETERMINED TO SEE THINGS DIFFERENTLY!
--ACIM

Offline ndrew

  • Member
  • Posts: 695
  • ....-.-.-.-.-.....
Re: New Mutation!!
« Reply #31 on: January 08, 2007, 10:53:30 PM »
Sorry to hear this Jeremy... wishin' u the best...

Drew

Offline RobT

  • Member
  • Posts: 319
Re: New Mutation!!
« Reply #32 on: January 08, 2007, 11:01:24 PM »
Jeromy-
Like the posting prior to mine said that ur smile is infectious.

Sorry to hear about ur mutation. Unfortunately I am not sure how that is cuz I have been on the same combo for over a yr, but I think I understand how stressful it can b for changing meds that often. To my understanding, each med(s) have different side-effects. Changing between ediff meds in a given month must have given ur share of side effects. I again have never been on either, so forgive me for my lack of knowledge on either of the meds.

I just hope that ur doc has some suggestions of which med to take. Best of luck!

RobT


Current meds: Atripla
VL: undetectable
CD4: 630

Offline thirtysomething

  • Member
  • Posts: 124
Re: New Mutation!!
« Reply #33 on: January 09, 2007, 12:24:21 AM »
sorry to hear that Jeromy. Be strong!  :)

Offline J.R.E.

  • Member
  • Posts: 7,260
  • Joined Dec-2003 Living positive, since 1985.
Re: New Mutation!!
« Reply #34 on: January 09, 2007, 07:50:58 AM »
Bad luck

(and, erm, which mutations exactly?)

- matt



Jeromy,

Sorry to hear whats happenning. But see if you can get a copy of that report, and perhaps post some of the information. You may get some ideas or suggestions.


Ray
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 25 mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


Diagnosed positive in 1985,.. In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started on  HAART on October 24th, 2003.

 As of 8/25/14,  t-cells are at 402, Viral load <40

 Current % is at 11%

  
 62 years young.

Offline pozguy75

  • Member
  • Posts: 1,239
    • POZitively Speaking
Re: New Mutation!!
« Reply #35 on: January 09, 2007, 01:12:16 PM »

Jeromy,

Sorry to hear whats happenning. But see if you can get a copy of that report, and perhaps post some of the information. You may get some ideas or suggestions.


Ray

I have attached a copy of the report here...I am resistent to the following:

Emtriva
Epivir

With a reduced susceptibility to Zerit, Retrovir, and Viread.

I also now have Dual-Tropic HIV or Mixed Population...I have both CCR5 and CXCR5 tropisms. This is from being on the Marviroc study: the CCR5 entry inhibitor. What seems to have happened, at the beginning of the study I was only CCR5, and I have now changed tropisms...so, I am no longer able to take a CCR5 inbitor (fusion or entry). Meaning that Fuzeon is no longer an option for me.

So...I will chat with the doctor this afternoon and see what the options are going to be...

[attachment deleted by admin]
Dx 2005
ATRIPLA

Offline Strayboy74

  • Member
  • Posts: 1,054
  • tastes like chicken
Re: New Mutation!!
« Reply #36 on: January 09, 2007, 03:09:20 PM »
*hug*

-joseph

Offline Javicho

  • Member
  • Posts: 268
Re: New Mutation!!
« Reply #37 on: January 09, 2007, 03:35:37 PM »
Sorry to heard that Jeromy, I hope the next one it will work for you  :-*

J.

Offline pozguy75

  • Member
  • Posts: 1,239
    • POZitively Speaking
Re: New Mutation!!
« Reply #38 on: January 09, 2007, 03:47:10 PM »
Well...doctor called and because of my latest results where my CD4 counts are good and my VL is undetectible, we have decided to keep my regimen for now. It seems to working...so we will keep an eye on things over the next couple of months and get a better guage in March.

So...wait and see as they say...
Dx 2005
ATRIPLA

Offline aupointillimite

  • Member
  • Posts: 3,229
  • FUS DO RAH!
Re: New Mutation!!
« Reply #39 on: January 09, 2007, 04:05:01 PM »
I believe I read somewhere that resistance to Epivir made the virus less virulent somehow... and my doc said that even when she had patients who were resistant to it, she'd keep them on Epivir...
Your tastebuds can't repel flavor of this magnitude!

Offline Tucsonwoody

  • Member
  • Posts: 396
Re: New Mutation!!
« Reply #40 on: January 09, 2007, 04:18:17 PM »
Here is a little bit of the article on aidsmeds that might explain why stay with Epivir still helps:

However, Epivir resistance might make the virus even more sensitive to other NRTIs, most notably Retrovir (even if HIV has mutations in its structure that would normally cause it to be resistant to Retrovir) and Viread.

http://www.aidsmeds.com/drugs/Epivir.htm

Whatever happens hope ya stay healthy and find a good combo to kick HIV's ass!

(Oh and keep making porn of course)
And I wished for guidance, and I wished for peace
I could see the lightning; somewhere in the east
And I wished for affection, and I wished for calm
As I lay there - Nervous in the light of dawn

Offline fearless

  • Member
  • Posts: 2,191
Re: New Mutation!!
« Reply #41 on: January 09, 2007, 07:01:43 PM »
Bit of a bummer, Jeromy.

All the best.
Be forgiving, be grateful, be optimistic

Offline newt

  • Member
  • Posts: 3,887
  • the one and original newt
Re: New Mutation!!
« Reply #42 on: January 09, 2007, 07:24:28 PM »
Mutation-wise - theroetically interesting but practically boring.  We share 6 mutations, but, strangely, have never met  :D - matt
"The object is to be a well patient, not a good patient"

Offline whizzer

  • Member
  • Posts: 364
Re: New Mutation!!
« Reply #43 on: January 09, 2007, 07:36:53 PM »
Jeromy,

Fuzeon is neither CCR5 nor CXCR4 tropism dependant.  It binds to neither receptor.  Fuzeon (ENF) binds to the first heptad-repeat (HR1) in the GP41 subunit of the viral envelope glycoprotein, thus preventing conformational changes required for fusion of the viral envelope and  CD4 cell membrane.  It's mechanism of action is independent of the tropism .  The prescribing information indicates ENF is equally active in vitro  against clades A, AE, C, D, E, F, and G as well as R5, X4, and dual-tropic viruses.

I don't see ENF on either of the genotype reports you listed, and I'm far too lazy to look up what mutations are resistant to ENF.  Anyways,  it may still be an option for you in the future..

It is a moot point since you are currently going to stay the course with your current regimen (which to me seems like a good call, if it ain't broke, don't fix it).

As a matter of curiosity, how can they get an accurate genotype if your VL is undetectable (I'm assuming you mean less than 50)?  I wasn't aware it could be done.

-Whizzer

Offline allopathicholistic

  • Member
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Re: New Mutation!!
« Reply #44 on: January 10, 2007, 12:05:58 PM »
yup, wait and see as they say jeromy. we'll be thinking of you

As a matter of curiosity, how can they get an accurate genotype if your VL is undetectable (I'm assuming you mean less than 50)?  I wasn't aware it could be done.

i'm curious too ....inquiring minds want to know

Offline Tucsonwoody

  • Member
  • Posts: 396
Re: New Mutation!!
« Reply #45 on: January 10, 2007, 12:17:33 PM »
This may explain about low VL and test:

Resistance testing may be useful for some with 'undetectable' viral loads

Genotypic resistance testing in individuals with an 'undetectable' viral load may be more reliable than currently thought, according to a report published in the September issue of the Journal of Acquired Immune Deficiency Syndromes. They argue that resistance testing in those with very low detectable HIV RNA levels (e.g. between four and 75 copies/ml) may be useful to inform treatment decisions in individuals who are experiencing viral load 'blips' or an unexpectedly slow response to a change in their antiretroviral regimen.

Full article at: http://www.aidsmap.com/en/news/632C4768-4E19-4D45-8AA0-0A6EF4075613.asp
And I wished for guidance, and I wished for peace
I could see the lightning; somewhere in the east
And I wished for affection, and I wished for calm
As I lay there - Nervous in the light of dawn

Offline pozguy75

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Re: New Mutation!!
« Reply #46 on: January 10, 2007, 12:53:29 PM »
Jeromy,

Fuzeon is neither CCR5 nor CXCR4 tropism dependant.  It binds to neither receptor.  Fuzeon (ENF) binds to the first heptad-repeat (HR1) in the GP41 subunit of the viral envelope glycoprotein, thus preventing conformational changes required for fusion of the viral envelope and  CD4 cell membrane.  It's mechanism of action is independent of the tropism .  The prescribing information indicates ENF is equally active in vitro  against clades A, AE, C, D, E, F, and G as well as R5, X4, and dual-tropic viruses.

I don't see ENF on either of the genotype reports you listed, and I'm far too lazy to look up what mutations are resistant to ENF.  Anyways,  it may still be an option for you in the future..

It is a moot point since you are currently going to stay the course with your current regimen (which to me seems like a good call, if it ain't broke, don't fix it).

As a matter of curiosity, how can they get an accurate genotype if your VL is undetectable (I'm assuming you mean less than 50)?  I wasn't aware it could be done.

-Whizzer

Well, the genotype was collected on Nove 16, and it took 6 weeks to get the results back. It was during that time that we switched from the Maraviroc to the Kaletra and remained on the Combivir. I wasn't undetectable then...My VL was aprroaching a little over 1000, so there was enough there to collect the data.

Now, my VL is <75 which was they are considering to be undectible...so, with the way my numbers are now, we aren't going to worry too much about the mutations until we see numbers slipping...

And thank you SO much for the info on Fuzeon, apparently I was misinformed...phew! But I can tell you I am no longer able to take the CCR5 entry inhibitors now...

Dx 2005
ATRIPLA

Offline cmhjeff

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Re: New Mutation!!
« Reply #47 on: January 10, 2007, 02:20:28 PM »
Well...doctor called and because of my latest results where my CD4 counts are good and my VL is undetectable, we have decided to keep my regimen for now. It seems to working...so we will keep an eye on things over the next couple of months and get a better gauge in March.

So...wait and see as they say...
I was thinking the same way since your current cocktail is controlling your virus I wouldn't be so quick to change. My original doctor changed my meds so often trying to get me undetectable that my genotype had me resident to most of the meds a year ago when I got the PML so my doctor put me on Trizivir which the report showed some Resistance but here I am undetectable. We'll all be here with you waiting until March.
Hugs

Offline thunter34

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  • His name is Carl.
Re: New Mutation!!
« Reply #48 on: January 10, 2007, 02:36:33 PM »
Jeromy,

I wanted to pose what might be viewed as a bit of a sensitive question here, but I hope you'll appreciate me raising it both out of concern for you personally and to discuss the question in the broader sense once again:

Is your doctor aware at all of your current porn work?

Do you think that there might be a potential for setting yourself up for mutation problems through the type of sex activity involved with that particular style of porn work?  I know the data behind the concepts of ''reinfection'' and/or ''superinfection'' are up for debate, but I was wanting get some current word from anyone more in the know than myself about what the latest word on this topic was.  It just crossed my mind that if there was a lot of fluid exchange between yourself and someone else who was already Combivir resistant, wouldn't that expedite resistance in you?  If so, might that problem potentially repeat itself? 

Anyone with some info to offer on this?
AIDS isn't for sissies.

Offline newt

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  • the one and original newt
Re: New Mutation!!
« Reply #49 on: January 10, 2007, 02:48:31 PM »
"It just crossed my mind that if there was a lot of fluid exchange between yourself and someone else who was already Combivir resistant, wouldn't that expedite resistance in you? "

Theoretically, yes.  But (1) the source would have to have enough virus to transmit - if he was undetectable this would be unlikely ... (2) the host would have to be immunologically receptive - who knows?

The most likely explanation for J's mutations, which don't seem that important anyway, is that he was on a combo that didn't get his viral load undetectable. 

- matt
"The object is to be a well patient, not a good patient"

 


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