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Author Topic: Brain Penetration  (Read 2284 times)

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Offline Magnus

  • Member
  • Posts: 63
Brain Penetration
« on: March 08, 2008, 09:04:22 AM »
Here is a good article from the UK with a section about the potisitive effects of meds with good brain penetration (page 5): http://www.aidsmap.com/files/file1002420.pdf

My brain is very precious to me (almost more than my body!) and this factor along would lead to choose a regime based on Nevirapine rather than efavirenz.

Anyone have any thoughts on this issue?

Offline Miss Philicia

  • Member
  • Posts: 24,506
  • celebrity poster, faker & poser
Re: Brain Penetration
« Reply #1 on: March 08, 2008, 02:37:33 PM »
As far as I know, a successful HAART regimen has greatly reduced the incident of dementia in HIV patients.  It's generally confined to late stage HIV progression, which hopefully most of us can greatly delay. 
"Iíve slept with enough men to know that Iím not gay"

Offline J.R.E.

  • Member
  • Posts: 7,276
  • Joined Dec-2003 Living positive, since 1985.
Re: Brain Penetration
« Reply #2 on: March 08, 2008, 03:54:47 PM »
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 25 mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


Diagnosed positive in 1985,.. In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started on  HAART on October 24th, 2003.

 As of 8/25/14,  t-cells are at 402, Viral load <40

 Current % is at 11%

  
 63 years young.

Offline Magnus

  • Member
  • Posts: 63
Re: Brain Penetration
« Reply #3 on: March 08, 2008, 06:20:27 PM »
Thanks Philly & Ray-

I guess my first priority should be a highly effective HAART as this seems to delay dementia regardless of brain penetration.

Philly i see your an Viramune, how do you find it?

Offline Miss Philicia

  • Member
  • Posts: 24,506
  • celebrity poster, faker & poser
Re: Brain Penetration
« Reply #4 on: March 08, 2008, 06:26:15 PM »
I'm not on viramune, though I was on it in the mid/late 90's when it first came out.  I don't recall having any issues with it, but that was obviously quite some time ago.
"Iíve slept with enough men to know that Iím not gay"

Offline Magnus

  • Member
  • Posts: 63
Re: Brain Penetration
« Reply #5 on: March 08, 2008, 07:58:08 PM »
Oops sorry thats JRE who is on Viramune- sorry about that :)

Offline John2038

  • Member
  • Posts: 1,529
  • Happiness is a journey, not a destination.
    • HIV Research News (Twitter)
Re: Brain Penetration
« Reply #6 on: March 09, 2008, 06:09:12 AM »
I'm also more concern by the brain than the body, and I'm also considering PIs that can pass the brain barer.
Thanks for these good information  :)

Offline J.R.E.

  • Member
  • Posts: 7,276
  • Joined Dec-2003 Living positive, since 1985.
Re: Brain Penetration
« Reply #7 on: March 09, 2008, 07:13:35 AM »
Oops sorry thats JRE who is on Viramune- sorry about that :)

Hello Magnus,

I've been doing pretty well with Viramune. It was the first line of treatment, that I was placed on, in October of 03. I am still on it, and continue to be undetectable as of my last blood test.

I was also mentioning here :

http://forums.poz.com/index.php?topic=19447.0


Take care-----Ray
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 25 mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


Diagnosed positive in 1985,.. In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started on  HAART on October 24th, 2003.

 As of 8/25/14,  t-cells are at 402, Viral load <40

 Current % is at 11%

  
 63 years young.

Offline Magnus

  • Member
  • Posts: 63
Re: Brain Penetration
« Reply #8 on: March 09, 2008, 10:29:13 AM »
Just read the other thread, sounds encouraging.

Actually taking pills twice a day sounds manageable.

I guess ultimately the meds i take will depend on whats going to work for me but i want to be as educated as I can before I have that conversation with my specialist.

Offline aztecan

  • Member
  • Posts: 5,429
  • 29 years positive, 57 years a pain in the butt
Re: Brain Penetration
« Reply #9 on: March 09, 2008, 11:13:13 AM »
I guess ultimately the meds i take will depend on whats going to work for me but i want to be as educated as I can before I have that conversation with my specialist.

Hey Magnus,

You certainly have the right idea. Educating yourself about the meds is definitely something that each of us should do to the best of our ability.

The article you posted was interesting. The list of meds that cross the blood-brain barrier also was interesting. I knew Zidovudine (AZT, Retrovir) was one that did. That is why I have never switched from it.

I didn't know Crixivan (Indinavir) also had good brain penetration. A golden oldie that the docs thought gave me a buffalo hump, it is still a very good med.

Thanks for the info and keep up the good work.

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline Magnus

  • Member
  • Posts: 63
Re: Brain Penetration
« Reply #10 on: March 09, 2008, 11:27:18 AM »
Hello Mark

Well i certainly hope my brain is as sharp as yours after 22 years with this disease (unless its cured before then!).

I will certainly post anymore info regarding this brain penetration issue and anything else interesting i can find.

Thanks
Magnus

Offline Miss Philicia

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  • Posts: 24,506
  • celebrity poster, faker & poser
Re: Brain Penetration
« Reply #11 on: March 09, 2008, 11:30:25 AM »
Can we first verify that this brain penetration issues is actually really as important as you are making it out to be in terms of HAART treatment?  Frankly I think you're over-hyping it.
"Iíve slept with enough men to know that Iím not gay"

Offline Magnus

  • Member
  • Posts: 63
Re: Brain Penetration
« Reply #12 on: March 09, 2008, 11:43:04 AM »
Well that's the big question in the article in my first post-

HAART that does not pass the Brain barrier does reduce brain damage, but does HAART that passes the Brain barrier further reduce damage?

Sorry if I'm over hyping it Philly but i do find it a very interesting question:)

 


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