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Author Topic: Treatment composition  (Read 1719 times)

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Offline BM

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Treatment composition
« on: May 30, 2009, 09:48:03 AM »
The guidelines I've read say that antiretroviral treatment should comprise at least two NRTIs and either a boosted PI or an NNRTI. Are these changing to accommodate the newer drug options? How durable do people think my current regimen (NtRTI, + boosted PI + integrase inhibitor) will be compared either of the suggested combinations?

Offline Miss Philicia

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Re: Treatment composition
« Reply #1 on: May 30, 2009, 10:10:04 AM »
The guidelines haven't "officially" changed yet to accommodate the new classes of integrase and/or entry inhibitors simply because testing has only been completed for patients with multiple resistance profiles.  Testing isn't yet done for other patients with mere "sensitive" readings or those with no resistance issues, but it is being done.

However, there are doctors that will prescribe these meds on an "off label" basis.  Like you, I'm also on Isentress, and have no reason to believe that it is not a durable medication.  I've been on it now for a year and half.
"Iíve slept with enough men to know that Iím not gay"

Offline newt

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Re: Treatment composition
« Reply #2 on: May 30, 2009, 10:37:52 AM »
The rule of thumb is at least 3 active drugs from 2 different classes (to prevent resistance by attacking HIv at at least 2 points in its replication cycle), so while not guidleline compliant, your combo is in principle a good mix. - matt
"The object is to be a well patient, not a good patient"


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