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Author Topic: Surprising Discovery: HIV Hides in Gut, Evades Eradication  (Read 1470 times)

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Offline Ptrk3

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Offline JakaTingkir

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Re: Surprising Discovery: HIV Hides in Gut, Evades Eradication
« Reply #1 on: August 31, 2014, 04:33:03 PM »
it’s all about the daily yoghurts

Offline mecch

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Re: Surprising Discovery: HIV Hides in Gut, Evades Eradication
« Reply #2 on: August 31, 2014, 04:35:05 PM »
Why is this a surprise or a discovery?  (I thought it has been known for years.... )
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline buginme2

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Re: Surprising Discovery: HIV Hides in Gut, Evades Eradication
« Reply #3 on: August 31, 2014, 04:40:19 PM »
Why is this a surprise or a discovery?  (I thought it has been known for years.... )

I was wondering the save thing.   This is old news isn't it?
Don't be fancy, just get dancey

Offline Ptrk3

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Re: Surprising Discovery: HIV Hides in Gut, Evades Eradication
« Reply #4 on: August 31, 2014, 05:12:25 PM »
I think this is the "money shot" from the report that is newsworthy to the microbiologist researchers:

Digging deeper, the researchers found the inflammatory response through IL-1β production was initiated in Paneth cells, which are known to protect the intestinal stem cells to replenish the epithelial lining. This is the first report of Paneth cell sensing of SIV infection and IL-1β production that links to gut epithelial damage during early viral invasion. In turn, the epithelial breakdown underscores that there's more to the immune response than immune cells.

Offline leatherman

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Re: Surprising Discovery: HIV Hides in Gut, Evades Eradication
« Reply #5 on: August 31, 2014, 06:24:38 PM »
Why is this a surprise or a discovery?  (I thought it has been known for years.... )
anyone who has been poz for more than a few yrs knows this. ;) I guess the science is finally just catching up to what is already known by pozzies, ID docs, and ASO clinics.
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline tryingtostay

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Re: Surprising Discovery: HIV Hides in Gut, Evades Eradication
« Reply #6 on: August 31, 2014, 10:53:21 PM »
And doesn't the gut reservoirs mimic ecoli? er something like that?  And that's part of the reason why our immune ignores it or something..  bah, nm me.  my loopyness is strong with the force today

Offline georgep77

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Re: Surprising Discovery: HIV Hides in Gut, Evades Eradication
« Reply #7 on: August 31, 2014, 10:57:03 PM »
I wonder how much money was invested in this wannabe discovery.
     
                                ;D
Come on Sangamo,  Geovax,  Bionor immuno, ...Make us happy !!!
+ 2008

Offline Basquo

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Re: Surprising Discovery: HIV Hides in Gut, Evades Eradication
« Reply #8 on: September 04, 2014, 09:22:35 PM »
This explains why Boston always wants to schedule an upper and lower endo, and sighs heavily whenever I say, "Sorry, just a leukapheresis this time, please."

Offline MitchMiller

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Re: Surprising Discovery: HIV Hides in Gut, Evades Eradication
« Reply #9 on: September 07, 2014, 03:54:49 AM »
The latest find that is related, is that benign bacteria particles are "leaking" from the gut and is likely a significant cause of inflammation associated with HIV even when the virus is controlled.  Renleva seemed to help.

Offline mecch

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Re: Surprising Discovery: HIV Hides in Gut, Evades Eradication
« Reply #10 on: September 07, 2014, 04:07:24 AM »
How does one measure the damage to an HIV+ person's gut? There must be a sliding scale, from none, to little, to some, to a lot, to debilitating and so on....
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline zach

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Re: Surprising Discovery: HIV Hides in Gut, Evades Eradication
« Reply #11 on: September 07, 2014, 08:31:29 AM »
i haven't shit myself in about a week, but i pissed myself yesterday. there's your sliding scale ;-)

Offline xinyuan

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Re: Surprising Discovery: HIV Hides in Gut, Evades Eradication
« Reply #12 on: September 13, 2014, 07:56:00 PM »
Mecch, two words:
rectal biopsy
:P

Researchers can also measure bacterial products (e.g., lipopolysaccharide or LPS for short) in the blood.

We've really known this as far back as 2004-2005 in some form or another. The virus loves hanging out in mucosal tissue (gut, sinuses, etc.), where most CD4's live.

http://www.nature.com/mi/journal/v5/n6/full/mi201282a.html

 


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