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Author Topic: Truvada+Tivicay=Facial Wasting  (Read 433 times)

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Offline altinosubra

  • Member
  • Posts: 4
Truvada+Tivicay=Facial Wasting
« on: August 27, 2014, 08:31:17 PM »
Greetings,

I am newly infected and started my HAART 6 months ago.

I have started noticing a substantial facial wasting lately and I am in panic mode. I have requested an appointment with my doctor to discuss this occurrence.

I am seriously considering a treatment interruption, and would like your opinion on the pros and cons on this decision.

Quality of life is very important, and due to cultural stigma, I cannot afford to be isolated due to my physical indication of my hit status.

In the past few days, I am experiencing severe depression. I have thought in partaking in clinical trials as to avoid HAART medications.

Could someone please refer me to the site that provides list of current clinical trials that recruit in United States?

Best wishes
4EverIHope

Offline Cojo

  • Member
  • Posts: 196
Re: Truvada+Tivicay=Facial Wasting
« Reply #1 on: August 27, 2014, 08:41:11 PM »
Hey there,

Slow down and breathe my friend! These two drugs are not known at all for lipatrophy. It was the D drugs like Zerit of old that had these terrible side effects. So, you may say....why is it listed as a possible side effect - it's called legal cover you ass pharma lingo.
Others with more knowledge will chime in I am sure, but until then, relax and stop worry - you are not having that side effect in 6 months and with these drugs

BTW,I take the same two as well and 100% no side effects -we are so blest
May 2011 - Tested Positive
June 2011 - CD4 330   16%   VL182,000 no resistance
Oct 6, 2011 - CD4 300  20%  VL 60,000
Oct 7, 2011 - start Truvada / Isentress
Nov 29, 2011 CD4 280 26% VL 54
Feb 7 2012 CD4 260 25% UD!
Mar 20 2012 CD4 400 28%
June 2012 CD4 330 26% UD
Sept 2012 CD4 450 32% UD
Dec 2012 CD4 310 28% UD
May 2013 CD4 500 32% UD
Oct 2013 CD4 460 33% UD
May 2014 CD4 360 33% UD
Aug 2014 swap out Isentress for Tivicay

Offline altinosubra

  • Member
  • Posts: 4
Re: Truvada+Tivicay=Facial Wasting
« Reply #2 on: August 27, 2014, 08:48:42 PM »
Thank you Cojo for your response.

While I was also optimistic, I believe the combination of these drugs has different effect from person to person.

Two days ago I went to see my skin care specialist who keeps before and after pictures. It was her after reviewing my before pictures notices and pointed that predominantly the left side of my face have lost volume, under my eye and cheeks.

I will be consulting also with my doctor tomorrow to find out their expertise on this subject matter.


Offline Cojo

  • Member
  • Posts: 196
Re: Truvada+Tivicay=Facial Wasting
« Reply #3 on: August 27, 2014, 08:55:54 PM »
It is always best to check with a doc to provide ease of mind, but I'd wager you dozen martini's that it is not lipatrophy. It is simply not part of the drug profile as it is known, and six months is way to short a time for it to happen.

You are doing the right thing in seeing the doc and I look forward to your follow up post that all is well.
Relax, seriously.
May 2011 - Tested Positive
June 2011 - CD4 330   16%   VL182,000 no resistance
Oct 6, 2011 - CD4 300  20%  VL 60,000
Oct 7, 2011 - start Truvada / Isentress
Nov 29, 2011 CD4 280 26% VL 54
Feb 7 2012 CD4 260 25% UD!
Mar 20 2012 CD4 400 28%
June 2012 CD4 330 26% UD
Sept 2012 CD4 450 32% UD
Dec 2012 CD4 310 28% UD
May 2013 CD4 500 32% UD
Oct 2013 CD4 460 33% UD
May 2014 CD4 360 33% UD
Aug 2014 swap out Isentress for Tivicay

Offline Miss Philicia

  • Member
  • Posts: 24,112
  • celebrity poster, faker & poser
Re: Truvada+Tivicay=Facial Wasting
« Reply #4 on: August 28, 2014, 08:35:14 AM »
Actually Cojo, facial lipoatrophy is a listed side effect for Truvada:

http://www.aidsmeds.com/archive/Truvada_1584.shtml

However, Truvada is a preferred NRTI because it has the least possibility to cause this.

Other than that, one must understand that lipoatrophy is a cellular disturbance that alters the mitochondrial RNA and DNA, which then effects the distribution of fat cells. This generally takes several years to occur when it happens. Additionally, it would be a symmetrical occurrence, not something that would happen on one side of the face, or in one arm, or in one leg, or in one buttock.
"Iíve slept with enough men to know that Iím not gay"

Offline leatherman

  • Member
  • Posts: 6,204
  • Google and HIV meds are Your Friends
Re: Truvada+Tivicay=Facial Wasting
« Reply #5 on: August 28, 2014, 10:00:46 AM »
I am seriously considering a treatment interruption
....
I have thought in partaking in clinical trials as to avoid HAART medications.
there is no need for a "treatment interruption". (Untreated HIV leads to AIDS and death, so I don't think you really want to make that choice anyway  ;) ) After consulting with your doctor, you would simply just change to a different regimen and start taking it the day after you stop your old regimen.

clinical trials are usually studies about HAART medications; so that's not a way to "avoid" meds. LOL Unless of course you're part of the study receiving placebos. LOL
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Online mecch

  • Member
  • Posts: 11,729
  • red pill? or blue pill?
Re: Truvada+Tivicay=Facial Wasting
« Reply #6 on: August 28, 2014, 10:42:40 AM »
Greetings,

I am newly infected and started my HAART 6 months ago.

I have started noticing a substantial facial wasting lately and I am in panic mode. I have requested an appointment with my doctor to discuss this occurrence.

Highly unlikely you have "substantial facial wasting" in 6 months.  Highly unlikely on your combo. But, i suppose in some rare rare case, its possible.  You have to get a doctor to diagnose that it is happening.  Also, has anyone beside yourself noticed?  If nobody else noticed, you might have a kind of dysmorphia.

I am seriously considering a treatment interruption, and would like your opinion on the pros and cons on this decision.


There is NO pro for a treatment interruption.  A person gets a treatment interruption ordered by a doctor under very rare circumstances.  Or maybe, in France, see below.

Quality of life is very important, and due to cultural stigma, I cannot afford to be isolated due to my physical indication of my hit status.

In the past few days, I am experiencing severe depression. I have thought in partaking in clinical trials as to avoid HAART medications
.

Yes quality of life is important.  What area of the world do you live in where you cultural stigma is so great that it is worrying you this much?  Of course there is stigma!  But, you probably need to hash your perceptions out here, AND with health professionals, and maybe a psychotherapist...  You might be unrealistically worried about you appearance.  You might be perceiving more potential stigma, then you are actually experiencing in the moment.  You have to talk to others to test your perception on these things.

And, what leatherman said. Far as I know there is no study out there that puts HIV+ people OFF medication, once on. EXCEPT one study - where people who were treated at seroconversion and reliably undetectable for a few years.  I think its mostly a study in FRANCE.   Is that you case?




Could someone please refer me to the site that provides list of current clinical trials that recruit in United States?

Best wishes
4EverIHope
« Last Edit: August 28, 2014, 10:48:21 AM by mecch »
ďFrom each, according to his ability; to each, according to his needĒ 1875 K Marx

 


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