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Author Topic: HIV antibodies block infection in reservoir-derived virus in lab study  (Read 1044 times)

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Offline Ptrk3

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  • Posts: 190

Offline Jmarksto

  • Member
  • Posts: 533
Re: HIV antibodies block infection in reservoir-derived virus in lab study
« Reply #1 on: August 27, 2014, 05:57:20 PM »
There seems to be quite a bit going on with antibodies (monoclonal and broadly neutralizing), which is promising.  I think Geobee indicated that there was a monoclonal AB trial at Quest with weekly injections achieving UD viral levels off ART.  Interestingly, Science Daily also published this a few weeks ago (apologies if it has already been posted).


www.sciencedaily.com/releases/2014/08/140813132118.htm



03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45%  VL 25
02/25/14 CD4   792/37%  VL UD
07/09/14 CD4 1004/39%   VL UD
11/03/14 CD4   711/34%   VL UD

Offline Almost2late

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  • Posts: 472
  • "The Nutcracker"
Re: HIV antibodies block infection in reservoir-derived virus in lab study
« Reply #2 on: August 29, 2014, 06:33:06 PM »
From the POZ treatment news, the same research stories..

http://www.pnas.org/content/early/2014/08/21/1414148111.abstract

http://www.niaid.nih.gov/news/newsreleases/2014/Pages/antibodiesHIVreservoir.aspx
 
I really try not to get my hopes up but with all these break-thrus its hard to lose hope  :)
"Every man has his own destiny: the only imperative is to follow it, to accept it, no matter where it leads him." - Henry Miller

http://www.youtube.com/watch?v=ZBkwPYq4nhQ

“Nothing in the world can one imagine beforehand, not the least thing, everything is made up of so many unique particulars that cannot be forseen.” - Nostradamus

Offline Matts

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  • Posts: 231
Re: HIV antibodies block infection in reservoir-derived virus in lab study
« Reply #3 on: August 30, 2014, 03:25:40 PM »
I think that You don't have to be clairvoyant to know what will happen.
It will be very hard to develop better drugs than Tivicay/Cabotegravir/EfdA.
I can imagine that big Pharma will stop the ART research and will concentrate on ABs like Gilead.  I think from 2025 or so the treatment will be monoclonalAB or BnAB or something like that as regular injections :)
triumeq

Offline Ptrk3

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  • Posts: 190
Re: HIV antibodies block infection in reservoir-derived virus in lab study
« Reply #4 on: August 30, 2014, 04:00:37 PM »
Matts:  does this article convey your thoughts on how things will play out (just trying to fully appreciate your comments and learn from them)?  Thanks for your perspective. I'm just a year into diagnosis and have been on Atripla since then, so I'm just want to get a realistic sense of possibilities of a "sterilizing" or "functional" cure.

Article:  http://i-base.info/htb/26949

Offline zettainaoru

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  • Posts: 50
Re: HIV antibodies block infection in reservoir-derived virus in lab study
« Reply #5 on: August 30, 2014, 07:36:49 PM »
I hope the cost will not be as high as IVIG. (soo expensive in indonesia).

Even IVIG which use random high density antibody, can make u undetectable up to 7 months.
Not to mention lower the viral reservoir.
 http://www.thebody.com/content/art51570.html

Who knows, long term use of bNabs might be the cure afterall.

Offline JakaTingkir

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  • Posts: 9
Re: HIV antibodies block infection in reservoir-derived virus in lab study
« Reply #6 on: August 31, 2014, 04:54:23 PM »
Matts:  does this article convey your thoughts on how things will play out (just trying to fully appreciate your comments and learn from them)?  Thanks for your perspective. I'm just a year into diagnosis and have been on Atripla since then, so I'm just want to get a realistic sense of possibilities of a "sterilizing" or "functional" cure.

Article:  http://i-base.info/htb/26949

sterilizing means cure....
functional means the scientist doesnt want any responsibility in the future...

am i wrong?

Offline Ptrk3

  • Member
  • Posts: 190
Re: HIV antibodies block infection in reservoir-derived virus in lab study
« Reply #7 on: August 31, 2014, 05:06:38 PM »
My understanding is that the term "sterilizing" cure means no HIV remains in the body.  "Functional" cure means that HIV remains in the body but is (naturally)suppressed by the immune system (i.e. to "non-morbid" levels so no OI's occur) without use of ARV's. 

 


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