Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
August 28, 2014, 10:08:26 PM

Login with username, password and session length


Members
Stats
  • Total Posts: 636494
  • Total Topics: 48310
  • Online Today: 258
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Radioactive Antibody "Missiles" Home In on HIV And related news thread  (Read 627 times)

0 Members and 1 Guest are viewing this topic.

Offline Mynewlife+

  • Member
  • Posts: 14
  • There is only one of you in all the universe
November 06, 2006 
Radioactive Antibody "Missiles" Home In on HIV   
   
 Image: MICHAEL FREEMAN/CORBIS 
 ANTIBODIES LINKED  to radioactive isotopes home in on and kill HIV-infected human cells in mice. 
It worked for treating cancer; now researchers have found they can send dollops of lethal radiation directly into HIV-infected cells using radioactive antibodies. So far the technique only works in mice, but investigators hope they can extend their proof-of-concept to a treatment capable of destroying all of the infected cells in a person's body under some circumstances. "Twenty-five years from the start of the epidemic, HIV is still an incurable disease--something completely different needs to be done to completely eradicate it," says nuclear medicine specialist Ekaterina Dadachova of the Albert Einstein College of Medicine in New York City, first author of a report published November 6 in PLoS Medicine that describes the results.

Antiretroviral drugs keep HIV at bay but do not kill the virus. Instead they stop it from reproducing and let the immune system clear out infected cells. Dadachova and her colleagues reasoned they could kill these cells directly and with minimal harm to the rest of the body if they could make radioactive isotopes cluster around the cells. Researchers have already found success against certain cancers by attaching radioactive isotopes to antibodies that seek out tumor cells. So the team linked radioactive bismuth 213 and rhenium 188 to antibodies designed to stick to two HIV proteins (gp41 and gp120) displayed on the surface of infected cells. To see if the antibodies would home in on the offending cells, they injected the compound into mice that contained human blood cells infected with HIV. The compound appeared to work safely: the treated mice had less than half the quantity of infected cells that their untreated counterparts did, and the animals suffered collateral damage to healthy blood cells only at the highest antibody dose, the group reports. Dadachova says the team is working with a pharmaceutical company to see if a clinical trial is warranted.
 
 
In principle, the technique could supplement antiretroviral therapy for a brief time, especially very early in an infection before the immune response has kicked in, says AIDS vaccine researcher David Montefiori of Duke University. "This is the type of treatment technology that gives one hope it might be possible to eliminate the virus," he says. Major uncertainties remain, though. As HIV infections progress, some infected cells go dormant and do not cover themselves in the proteins, or antigens, that antibodies recognize. Treatment, let alone cure, is only possible, Montefiori says, "if this therapy is effective in killing HIV -infected cells in humans, as it was in mice, and if the latently infected cells can be induced to express viral antigens. Those are two big if's." --JR Minkel 


Share your knowledge, we know too much to waste it.. Share your joy, we all want it... Share your pain, it won't last forever.. Nothing does.
Me

I live in turbulence to rest in peace after

You live you learn
You love you learn
You cry you learn
You lose you learn
You bleed you learn
You scream you learn
ALANIS MORISSETTE

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.