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Author Topic: Missed a night of Atripla. I have Stribild. Should I take it?  (Read 225 times)

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Offline SaveMeOprah

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Missed a night of Atripla. I have Stribild. Should I take it?
« on: December 17, 2014, 09:24:48 PM »
Long story short... I have been on Atripla for about four months. Today I was going to refill my prescription but by the time I got off from work the pharmacy was closed. Now I have to wait until tomorrow morning even though I take Atripla every night at 11pm. I have missed one dose since starting treatment in september. However, I have Stribild in my medicine cabinet. Should I take one dose of Stribild only for tonight. I think it would be safer to take one dose of a different antiretroviral than to take nothing at all. I would take one dose of Stribild, and than one does of Atripla tomorrow moring. And then go back to my regular routine tomorrow night. That would be three doses of antiretroviral in 24 hours. But better safe than sorry, I say. i don't want to build resistance.  What do you guys think?
« Last Edit: December 17, 2014, 09:27:53 PM by SaveMeOprah »

Offline Jeff G

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Re: Missed a night of Atripla. I have Stribild. Should I take it?
« Reply #1 on: December 17, 2014, 09:29:23 PM »
Missing one dose of Atripla is not going to harm you, just donít make a habit of it . Take your dose tomorrow night and forget about the Stribild Ö its not necessary . Atripla has a long half life so like I said Ö. missing a dose on a blue moon is no big deal .

Offline SaveMeOprah

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Re: Missed a night of Atripla. I have Stribild. Should I take it?
« Reply #2 on: December 17, 2014, 09:33:19 PM »
Are you sure. What is the worst that Stibild can do? And is taking NOTHING better than taking Stribild for one night?

Offline Jeff G

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Re: Missed a night of Atripla. I have Stribild. Should I take it?
« Reply #3 on: December 17, 2014, 09:41:50 PM »
Im am absolutely 100% confident that my advice is sound . Just take your Atripla tomorrow night and do not stress over this .

Offline leatherman

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Re: Missed a night of Atripla. I have Stribild. Should I take it?
« Reply #4 on: December 17, 2014, 10:27:52 PM »
Atripla has been studied (along with some other meds) and what has been found is that 95% or greater adherence will still result in successful therapy. Atripla has been even further studied in the FOTO study which has reviewed taking Atripla five days on and then two days off. This schedule was studied for the purposes of 1) seeing if med levels would stay at appropriate levels, while 2) reducing the cost of the medications needed (taking it fewer days results in smaller cost per month) and 3) reducing side effects. While little difference was seen in side effects, the plan of 5on-2off was successful and helped confirmed that >95% adherence would result in successful treatment.

The gist of all this is that missing one day of meds, especially Atripla, will not allow HIV to gain any foothold at all.

Quote
What is the worst that Stibild can do?
However, I would point out that switching out to another med for one day is a terrible idea. Stribild and Atripla are comprised of different meds. While I seriously doubt that taking on day of Stribild would cause any resistance to happen to those drugs, taking one day of different meds and exposing the HIV in your system to those meds for such a short duration is definitely not recommended.

Quote
And is taking NOTHING better than taking Stribild for one night?
Yes.
You skipped a med. end of story. Now get back on schedule tomorrow.  ;)
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline AusShep

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Re: Missed a night of Atripla. I have Stribild. Should I take it?
« Reply #5 on: December 17, 2014, 11:43:11 PM »
good advice above, but I'd like to add that you really should start refilling your prescriptions 3-4 days early until you build up a contingency supply so this doesn't happen again.

It sucks if you, the pharmacy, or insurance company causes a delay, or if you'll be out of town when a refill is due if you let yourself run out every time.  You can build up a one month contingency in a year pretty easily.


Offline eric48

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Re: Missed a night of Atripla. I have Stribild. Should I take it?
« Reply #6 on: December 18, 2014, 04:12:53 AM »
Since Mikie mentionned FOTO, I hereby provide a link to it

www.tinyurl.com/HPC-FOTO
NVP/ABC/3TC/... UD; CD4 > 1000; CD4/CD8 ~ 2.0   safety stock : 3 months (2013: FOTO= 5d. ON 2d. OFF ; 2014: NCT02157311 = 4d. ON, 3d. OFF)

 


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