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Author Topic: Sirolimus/rapamycin and HIV  (Read 1177 times)

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Offline geobee

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Sirolimus/rapamycin and HIV
« on: April 04, 2014, 01:40:01 PM »
This is interesting -- an immunosuppressant drug for use after transplantation stops T-Cells from having CCR5 receptors and seems to reduce the reservoir. 

"Researchers studying the effects of immune suppressant drugs on  transplant patients with HIV have made a surprising discovery: A drug intended to hobble the body's defense system may actually help destroy dormant reservoirs of the virus that causes AIDS.

In a paper published this week in the American Journal of Transplantation, authors found that when a small group of transplant patients received the drug sirolimus, they experienced a two- to threefold drop in HIV levels, whereas patients who received other immunosuppressants did not."

Here's the link:

http://www.latimes.com/science/sciencenow/la-sci-sn-can-transplant-drugs-help-to-eliminate-lingering-hiv-infections-20140403,0,557818.story

Offline buginme2

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Re: Sirolimus/rapamycin and HIV
« Reply #1 on: April 04, 2014, 01:43:57 PM »
Is it just me....or do all these new "cure" treatments sound a hell of a lot worse than the disease?

Offline Ann

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Re: Sirolimus/rapamycin and HIV
« Reply #2 on: April 04, 2014, 03:13:08 PM »
Is it just me....or do all these new "cure" treatments sound a hell of a lot worse than the disease?

Kinda like whacking your thumb with a hammer to get rid of a hangnail you mean? Yep. I've thought that too.
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Offline Cosmicdancer

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Re: Sirolimus/rapamycin and HIV
« Reply #3 on: April 04, 2014, 03:16:07 PM »
The article referenced the 2 Berlin patients that had been cured.  I thought there was just Timothy Ray Brown.  There's a recently published book about the Berlin patients.  Here it is listed on Amazon.com. 

http://www.amazon.com/Cured-Patients-Defeated-Forever-Changed-ebook/dp/B00DMCV4N0/ref=sr_1_1?ie=UTF8&qid=1396638704&sr=8-1&keywords=nathalia+holt
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Offline xinyuan

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Re: Sirolimus/rapamycin and HIV
« Reply #4 on: April 06, 2014, 07:09:09 PM »
Interesting hypothesis for rapamycin.

I agree. It's a bit extreme to smash the entire immune system, just to get at some reservoir. To be quite honest, the drug's complete effects don't seem to be completely understood by the medical community.

As for the Berlin patients: yes, there are 2. A little while back, I was surprised on hearing about the one before Timothy Brown. That patient was conferred controller status by his genetics. However, he still produces a significant amount of virus (see TAG and NEJM link below).

His case sparked the original idea of treatment interruptions, which have mostly failed.

http://en.wikipedia.org/wiki/The_Berlin_Patient

http://tagbasicscienceproject.typepad.com/tags_basic_science_vaccin/2014/02/update-published-on-the-first-berlin-patient.html

http://www.nejm.org/doi/full/10.1056/NEJMc1308413

Offline Mishma

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Re: Sirolimus/rapamycin and HIV
« Reply #5 on: April 22, 2014, 05:06:17 PM »
What drug does the medical community know the complete effects?
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