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Author Topic: Worried about all these mutations  (Read 883 times)

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Offline jaywalkor

  • Member
  • Posts: 4
Worried about all these mutations
« on: April 16, 2014, 09:59:45 PM »
Summary of Mutations Observed
RT M41L, I94UR,P95P/T,G99G/R,Q102K,K122K/ED123e,C162Y,D177E, AND 19 OTHERS (TOO TIRED TO TYPE THEM ALL)
IN 14 OF THOSE
PR 9 OF THOSE

Resistant to Viracept

Possible resistance to Norvir, Retrovir
All other drugs say Genotypic = Sensitive (what does that mean?)

Worried!!!!!!!!!  Physicians Assistant tried to grab the doctor when she saw all this, but Dr. had left for a meeting.

So here's my story and maybe some venting:

Infected mid-Feb, Like clock work, I got the 2 week 'worst flu ever'.  So prelim poz, confirmed with Labs: 530 CD4, VL 400,000

I didn't know anything...so came here and did some other research which seemed to suggest CD4 530 is good and VL 400,000 isn't all that significant in first few weeks of infection.  Also had a bad urinary tract that was causing fever and not responding to CIPRO, Augmentin fixed that.  So I was feeling better when I went to the Dr. today with the decision to wait a few months for next blood work to make a decision on meds.  BTW - They recommend Atripla for everyone that walks in positive because 'all their patients that take Atripla are undetectible'.  I had already decided to ask about alternatives to Sustiva, if I did decide to start meds.

So, now I've left the Dr's office not knowing what all this means.  Since I had previously told her my intention to not take meds for the first three months, I won't have a way to have these questions answered for 3 months at my next blood work.  I have this report in my hand and can't find any easy answers available like those available for CD4 counts and VL opinions.  Any help would be appreciated, whether based on knowledge or experience.

This site really calmed me down when I first found out.  Thanks to all who share here.


Offline zach

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  • Posts: 1,241
Re: Worried about all these mutations
« Reply #1 on: April 16, 2014, 10:16:11 PM »
theres something you're not seeing, don't freak out... the genotype sensitivity should have a score with it. sensitive is actually what you want, the alternative is resistant, it refers to the virus, not to you. wait to speak to your doctor, and get a much more educated answer than this. but everything is going ok. so you're resistant to a couple of meds, there are others, no great loss

Offline AusShep

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  • Posts: 207
Re: Worried about all these mutations
« Reply #2 on: April 16, 2014, 10:43:14 PM »
As Zach said, sensitive is what you want.  Your doctor will probably try to pick a regimen with no/few drug resistant mutations present, that should be another column on your report. 

I found out through a clusterfuck that I have about 30 mutations, one that impacts most PIs, including the ones I was taking.  My results still say sensitive for all of the PIs, and I was undetectable on a PI/NRTI program anyway. 

Reading some of the detailed drug info, it usually takes a specific combination of several mutations to make a particular drug totally ineffective/resistant, and I wouldn't worry one iota about your AZT resistance.

Offline jaywalkor

  • Member
  • Posts: 4
Re: Worried about all these mutations
« Reply #3 on: April 16, 2014, 10:51:06 PM »
Thanks guys, feel better already.  Gonna just stick with the plan and whatever happens will happen. 


Offline pittman

  • Member
  • Posts: 190
Re: Worried about all these mutations
« Reply #4 on: April 17, 2014, 06:35:36 PM »
Also, resistance is not a yes/no thing. There are degrees to it.  When tested, I showed up as having some resistance to one of the drugs in the combo I was put on, but the doctor explained that it was well below the threshold of concern. 

Several years later, I have been undetectable on every test after the first couple months.

 


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