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Author Topic: Stopping Truvada because of osteoporosis  (Read 1509 times)

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Offline Veritee

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Stopping Truvada because of osteoporosis
« on: January 06, 2014, 10:57:20 AM »
I have quite severe osteroporosis - might or might not be due to Truvada (emtricitabine and tenofovir disoproxil fumarate) which is a component of Atripla, but could also just be something I would have got anyway. I am 60.


I have been advised not to stop Atripla but to take meds to protect my bones and stop them getting worse.

I have tried taking once weekly Alendronate (Fosamax). It did not agree with me and anyway have just been told I need something more than this/

They want me to have zoledronic acid as an intravenous (IV) dose in hospital.
Has anyone had this and what were the effects, how did it go?

Should I also change my HIV med from Atripla.
What do you think?
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Offline Ann

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Re: Stopping Truvada because of osteoporosis
« Reply #1 on: January 06, 2014, 11:05:47 AM »
Hi Veritee, long time no see.

I removed your post from a nearly four-year-old thread where you posted it. This way you'll get answers to your own question instead of people talking to the original poster of the other thread, which would only confuse things. It's always better to start your own thread when you have specific treatment questions, rather than piggy-backing onto someone else's.

Can you take Ziagen (abacavir)? You'd need to have the sensitivity test first. If you can take it, you could switch out the Truvada portion of the Atripla for Kivexa and change the Sustiva portion out to something else as well.

Why does your doctor want to keep you on Atripla?
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Offline newt

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Re: Stopping Truvada because of osteoporosis
« Reply #2 on: January 06, 2014, 11:18:48 AM »
Hello

The drug in question that may be hurting your bones is tenofovir. So like Ann says perhaps you can just swap this for abacavir. There may be some caution on abacaviur for older folk becuase it seems to raise the risk of heart attack. But this said, you can construct a decent combination without tenofovir or abacavir, several these days.

- matt
"The object is to be a well patient, not a good patient"

Offline rocky48

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Re: Stopping Truvada because of osteoporosis
« Reply #3 on: January 21, 2014, 12:45:44 PM »
 
Posts: 36

Switching from Atripla

on: December 17, 2013, 07:45:45 PM

Wondering if anyone has had bone thinning while on Atripla.  I started on Atripla  April 23, 2011 and my bone density test shows some bone thinning as of Dec. 2, 2013. My PCP is thinking it maybe from the Atripla or my parathyroid. My id doctor said, Atripla can in a few cases cause this problem. So, he has now started me on Norvir, Epzicon and Reyataz. He also told me if the endocrinologist fines the problem to be from my thyroid I could which back to the Atripla. 

Anyone have opinion. By the way I am 65.
Started Atripla on 4/23/11
5/27/11   CD4 - 572 VL - 130
9/30/11   CD4 - 566 VL - UD
3/23/12   CD4 - 640 VL - UD
9/21/12   CD4 - 699 VL - UD

Offline wolfter

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Re: Stopping Truvada because of osteoporosis
« Reply #4 on: January 21, 2014, 03:25:01 PM »
I was diagnosed with osteoporosis and I'm only in my 40's.  My doctor indicated that it was probably the tenofovir.  The preferred course of action would be a med change.  Due to severe resistance issues, I had to settle for taking Boniva.

Complacency is the enemy.  ;)  Challenge yourself daily for maximum  return on investment.

Offline buginme2

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Re: Stopping Truvada because of osteoporosis
« Reply #5 on: January 21, 2014, 04:12:28 PM »
How about Tivicay and Epzicom (kivexa),  then when the one pill combo is approved you could take that and you would still only have one pill to take each day.

 Could also use this as an excuse to get off the Atripla,  seems to be the consensus these days as not many people are prescribed it as a new med  these days.   Seems to be a hold over from the past. 
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Offline alberche

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Re: Stopping Truvada because of osteoporosis
« Reply #6 on: March 30, 2014, 06:59:10 PM »
Dear Veritee,

I had the same problem 4 years ago. My doc changed my meds from Truvada+Reyataz to Truvada+Intellence (Etravirine, an NNRTI). And, a year later, to Kivexa+Intellence.

It seemed to partially stop bone density loss. But I haven't recovered the density I lost in those first years on treatment. As my condition is not too severe so far, my doc is treating me with D vitamine supplements, tocopherol, and I am doing some exercise and taking sunbaths everytime the wheather permits it.

I am 47 years old right now.

Talk to your doc on the possibility of a medication change. Maybe this will help you to stop it or even improve your bone density.

I wish you will be better.

Regards,

 8)
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Offline tednlou2

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Re: Stopping Truvada because of osteoporosis
« Reply #7 on: March 30, 2014, 11:24:23 PM »
I'm sorry to hear about the bone issues, but glad to hear it has been diagnosed, so appropriate changes and monitoring can be done. 

Before starting meds, particularly a tenovir-containing regimen, is it recommended to have a baseline bone scan done?  That way you can see where things were before the med, so you aren't wondering whether it was there all along?

Offline sfpvguy41

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  • Posts: 115
Re: Stopping Truvada because of osteoporosis
« Reply #8 on: March 31, 2014, 02:15:01 AM »
I wrote this detailed post about my experience a while back, was told it was helpful by some so hope it helps you.

http://forums.poz.com/index.php?topic=50523.msg605215#msg605215
Labs: (undetectable since 2005)
12/13: 634 cdr, 37.3%, 758 cd8, total chol 183, triglycerides 131
8/13: changed to Edurant from Reyataz
12/12: 828 cd4, 34.5%, 1078 cd8, total chol 192, tri 196
12/11: 787 cd4, 37%, 979 cd8.
9/11: 758 cd4, 38%, 944 cd8, und.
8/11 dropped norvir, incr reyataz to 400 mg
6/11: 621 CD4 CD4% 41, CD8 680! Undetectable. Creatinine and eGFR are ok now.
Switched from Truvada to Epzicom in late April 2011
AGT/AST and creatinine back to normal mid-April.
Cut Norvir from regimen.
Switched back to Reyataz/Norvir late Feb 2011
2/11: CD4 664 34%, CD8 963, diagnosed with osteoporosis, high AGT/AST and creatinine.
12/10: CD4: 676 CD4%: 34 CD8: 1012
Switched from Reyataz/norvir to Isentress 10/10
8/10: CD4: 731 CD4%: 40 CD8: 866
Diagnosed Sept. 2002 started meds May 2005.

 


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