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Author Topic: HIV and Aging  (Read 747 times)

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Offline Hoyland

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  • Posts: 70
HIV and Aging
« on: December 19, 2013, 07:06:35 PM »
Quote
The intersection of aging and HIV/AIDS is a looming ‘epidemic within an epidemic.’ This paper reviews how HIV/AIDS and its therapy cause premature aging or contribute mechanistically to HIV-associated non-AIDS illnesses (HANA). Survival with HIV/AIDS has markedly improved by therapy combinations containing nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors, and protease inhibitors (PIs) called HAART (highly active antiretroviral therapy). Because NRTIs and PIs together prevent or attenuate HIV-1 replication, and prolong life, the population of aging patients with HIV/AIDS increases accordingly. However, illnesses frequently associated with aging in the absence of HIV/AIDS appear to occur prematurely in HIV/AIDS patients. Theories that help to explain biological aging include oxidative stress (where mitochondrial oxidative injury exceeds antioxidant defense), chromosome telomere shortening with associated cellular senescence, and accumulation of lamin A precursors (a nuclear envelop protein). Each of these has the potential to be enhanced or caused by HIV/AIDS, antiretroviral therapy, or both. Antiretroviral therapy has been shown to enhance events seen in biological aging. Specifically, antiretroviral NRTIs cause mitochondrial dysfunction, oxidative stress, and mitochondrial DNA defects that resemble features of both HANA and aging. More recent clinical evidence points to telomere shortening caused by NRTI triphosphate-induced inhibition of telomerase, suggesting telomerase reverse transcriptase (TERT) inhibition as being a pathogenetic contributor to premature aging in HIV/AIDS. PIs may also have a role in premature aging in HIV/AIDS as they cause prelamin A accumulation. Overall, toxic side effects of HAART may both resemble and promote events of aging and are worthy of mechanistic studies.

http://www.nature.com/labinvest/journal/vaop/ncurrent/full/labinvest2013142a.html

Offline leatherman

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Re: HIV and Aging
« Reply #1 on: December 19, 2013, 09:21:55 PM »
"premature aging"?? hmmm wonder if they understand that without HIV meds that "premature aging" (also known as "death") usually happens 30-50 sooner? while HIV meds might cause some premature aging their ability to delay death by decades is a pretty good trade-off imho  :D ;D
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline mitch777

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Re: HIV and Aging
« Reply #2 on: December 19, 2013, 10:03:14 PM »
"premature aging"?? hmmm wonder if they understand that without HIV meds that "premature aging" (also known as "death") usually happens 30-50 sooner? while HIV meds might cause some premature aging their ability to delay death by decades is a pretty good trade-off imho  :D ;D

I agree but as I will be facing a judge to determine my disability next summer I would love to have evidence to convince bureaucratic (you fill in the blank) that this disease takes a toll. Especially for us LTS.

Not only the judge, but the general public, family and friends. They need to know.

Studies like this are desperately needed.
31 years hiv+ (oct. 2013) with a curtsy.

 


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