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Author Topic: Is there any pro recommendation about delay of taking meds?  (Read 946 times)

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Offline pengwayne

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  • Posts: 2
Is there any pro recommendation about delay of taking meds?
« on: December 11, 2013, 02:51:04 AM »
Hi eneryone,

I have a question about meds taking delay.
Yes, I know the good behavior is to take them on time.
For some reason, I often miss the regular time to take pills , maybe three times a week.
Is there any potentially impact on it ?

Someone told me that 10  or 30 minutes at least is OK.
But if I delay over one hour or more. I am nor sure about it.
So,could you please share some pro recommendations or documents with me to let me clear this answer?

Thanks in advance!

Offline newt

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Re: Is there any pro recommendation about delay of taking meds?
« Reply #1 on: December 11, 2013, 05:09:49 PM »
+2 hrs past time for dose is safe

- matt
"The object is to be a well patient, not a good patient"

Offline pengwayne

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  • Posts: 2
Re: Is there any pro recommendation about delay of taking meds?
« Reply #2 on: December 12, 2013, 02:55:00 AM »
Hi Matt,

Thanks for your reply!
Is that from any document or doctor's guidance?
 :)

Wayne

Offline witch

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Re: Is there any pro recommendation about delay of taking meds?
« Reply #3 on: December 12, 2013, 09:38:39 AM »
The HIV-1 replication cycle is 24 hours.

Because of that, if you take your medication a few hours earlier or later than scheduled, it would not be a problem.

When I start a new combo and have insomnia issues, I often switch from taking it before bed to taking it in the morning or at noon. If that doesn't work, I switch again to taking it before bed. The time differences are of the order of 8 hours yet I am still undetectable.

Taking your hiv meds every day is more important than taking them at exact time.

My Dr. is paranoid about taking it at the exact time. When I went to Europe for vacation, she told me to take the pills at the time corresponding to the time I was taking them in USA (there was 8 hours time difference between time zones). I deemed that a total nonsense and took it at the same time of the day in Europe. I was still undetectable when I came back to USA. So a few hours switches don't really matter as long as you take it every day.

Offline newt

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  • the one and original newt
Re: Is there any pro recommendation about delay of taking meds?
« Reply #4 on: December 12, 2013, 11:59:23 AM »
It's a general rule of thumb well held

My doctor says +2 hours.

i-Base, a UK treatment organisation says +1 hours (see http://i-base.info/guides/starting/adherence).

The "official" advice is to take your meds at the same time every day but no-one ever says what this means.

Many modern combinations, including ones containing efavirenz, allow the drugs to stay in the body for much longer than 24 hours, so the odd extra +2 hours on a dose won't matter.

- matt
"The object is to be a well patient, not a good patient"

Offline Dr.Strangelove

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  • Posts: 208
Re: Is there any pro recommendation about delay of taking meds?
« Reply #5 on: December 12, 2013, 09:06:20 PM »
According to this paper, the HIV-1 replication cycle is 52 hours:

Quote
We find that HIV requires an average of 52 h between export of virions in one generation to export in the next, with most of this (33 h) taken up by reverse transcription.

The timing of taking the meds (like once a day) is not related to the time required by HIV to replicate. The time window of +- 1 or 2 hours is only relevant in terms of keeping levels of that drug in the blood high enough to suppress any HIV-replication (however long that may take).

 


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