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Author Topic: HIV replication process  (Read 597 times)

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Offline fastncurious

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HIV replication process
« on: October 11, 2014, 12:32:23 PM »
Hello,

I have 3 questions regarding HIV:

1. I was wondering what keeps the HIV RNA strands and the enzymes together in close proximity after the HIV's fusion with the cell's envelope. I was wondering if they are somehow physically bound to each other (and then the process of infection advances one step after another), or if they are not bound at all, which in case the entire process is totally random, relying on multiple HIV virions penetrating the cell, and then the process advances when enzymes of one virion get in proximity to RNA of another virion (For instance in case of RT when the virus penetrates the cell it releases 2 RNA strands and 3 enzymes. In my understanding if nothing keeps RT and the RNA strands together, they would get 'lost' in the cell. They have to be in proximity to each other in order for the process of infection to continue. If they do get 'lost' then the process would have to rely on other virions to penetrate the cell, then use RT of one virion working on RNA of another virion, as they are both hanging out inside the cell, a process with is totally random and whose probability increases as note visions are penetration the cell. Same for the IN, and Protease).

2. When multiple HIV virions infect a T cell, how many times will the HIV genetic information be integrated to the cell's DNA?

3. Kinda related to #1, but can one single virion infect a T cell, or the probability for it to happen is almost zero?

Thanks,
FastAndCurious

Offline Jeff G

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Re: HIV replication process
« Reply #1 on: October 14, 2014, 06:51:45 AM »
Welcome to the forum . Please take a minute t introduce your self and tell us a little about what brought you here . Do you have HIV ? .

Here is some information about HIV . http://www.ashm.org.au/images/Publications/Monographs/HIV_Management_Australasia/HIV_Management-Chapter_1.pdf

Offline tryingtostay

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Re: HIV replication process
« Reply #2 on: October 14, 2014, 10:57:55 AM »
This is a long article but there are scientists trying to figure out the answer to your 1st question.  Great read.  Now lets hurry up and get here 2020! :)

The Diseaseome Could Take Medicine Beyond the Genome

 


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