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Author Topic: Reservoirs in macrophages may be tackled therapeutically.  (Read 744 times)

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Offline Giancarlo

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  • Posts: 10
Reservoirs in macrophages may be tackled therapeutically.
« on: November 21, 2013, 03:59:51 PM »
This looks like another exciting piece of news...
What do you think?

"CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells", Journal of Experimental Medicine, Vol. 210, No. 12, (November 18, 2013)
http://jem.rupress.org/content/210/12/2523

Abstract:
HIV-1–infected macrophages likely represent viral reservoirs, as they accumulate newly formed virions in internal virus-containing compartments (VCCs). However, the nature and biogenesis of VCCs remain poorly defined. We show that upon HIV-1 infection of primary human macrophages, Gag is recruited to preexisting compartments containing the scavenger receptor CD36, which then become VCCs. Silencing of CD36 in HIV-1–infected macrophages decreases the amount of virions released. Strikingly, soluble anti-CD36 antibodies, but not the natural ligands of CD36, inhibit release of virions from HIV-1–infected macrophages and the transmission of virus to CD4+ T cells. The effect of the antibodies is potent, rapid, and induces the retention of virions within VCCs. Ectopic expression of CD36 in HeLa cells renders them susceptible to the inhibitory effect of the anti-CD36 mAb upon HIV-1 infection. We show that the anti-CD36 mAb inhibits HIV-1 release by clustering newly formed virions at their site of budding, and that signaling via CD36 is not required. Thus, HIV-1 reservoirs in macrophages may be tackled therapeutically using anti-CD36 antibodies to prevent viral dissemination.
Nov 2011: HIV-
Jul 2012: HIV+
Aug 2012: VL 8,900 / CD4 822 (28%)
Oct 2012: VL 13,500 / CD4 887 (30%)
Jul 2013: VL 9,000 / CD4 ?
Sep 2013: VL 24,000 / CD4 625 (34%)
Oct 11th 2013: Start Atripla
Nov 7th 2013: VL 84 / CD4 665 (37%)
Dec 11th 2013: VL UD (<40) / CD4 960 (35%)

Offline Tadeys

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  • Posts: 159
Re: Reservoirs in macrophages may be tackled therapeutically.
« Reply #1 on: November 21, 2013, 04:33:36 PM »
There has been a lot of talk about macrophages been a very large reservoir of HIV, especially in the Spleen. There seems to be a few ways to reduce this reservoir; hopefully this is another. Time will tell.

Offline Skydrake

  • Member
  • Posts: 41
Re: Reservoirs in macrophages may be tackled therapeutically.
« Reply #2 on: November 25, 2013, 09:38:22 AM »
"CD36 molecule(thrombospondin receptor):

....is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency"


Source:
http://www.ncbi.nlm.nih.gov/gene/948

With so many functions, having anti-CD36 antibodies in the blood can be not so healthy.

 


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