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Author Topic: HIV-1 replication without integration may help HIV-1 persist in vivo  (Read 806 times)

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Offline Tadeys

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  • Posts: 159
Now, a team of researchers led by Dr. David N. Levy, Associate Professor of Basic Science and Craniofacial Biology at the New York University College of Dentistry (NYUCD), have discovered a new way that HIV-1 reproduces itself which could advance the search for new ways to combat infection.

For decades, scientists have been confident that HIV-1, the virus that causes AIDS, must insert its genetic material into a cell’s DNA in order to reproduce. This process, called “integration,” makes the virus a permanent part of the cell. Some of these infected cells can remain as long as the person is alive, and this is one reason why HIV+ individuals must remain on anti-HIV drugs for life.

Dr. Levy’s National Institutes of Health (NIH) funded research, “HIV-1 replication without integration,” published today on-line in the Journal of Virology, with lead author Dr. Benjamin Trinité, a post-doctoral fellow in Dr. Levy’s laboratory, has shown HIV-1 can sometimes skip this integration step entirely.

“Although this is not the virus’ main method for replicating, having this option available can help HIV survive,” said Dr. Levy. “These new findings suggest one mechanism by which HIV may be surviving in the face of antiviral drugs, and suggests new avenues for research into eliminating infection.”

The integration step is highly inefficient and actually fails up to 99% of the time, leaving most viruses stranded outside of the safe harbor of cell’s DNA. It has been assumed that these stranded, or “unintegrated” viruses were unable to reproduce, but Dr. Levy’s team has found that if the conditions are right they can generate new viruses that infect new cells.

The team also found that the unintegrated viruses can survive for many weeks in cells, allowing HIV to “hide out” in a dormant state. The ability of HIV-1 to go dormant helps it avoid elimination by antiviral drugs and immune responses.

“There is intense interest by researchers in the idea that new drugs might be developed to help to completely eliminate the virus from infected individuals,” said Dr. Levy. “We think that the new replication mechanism we have found could provide a target for drugs designed to eliminate infection.”

Dr Levy notes, an interesting phenomenon which other researchers have observed is that some bacteria which live in our mouths can stimulate HIV-1 to emerge from its dormant state.

“NYUCD has some terrific groups of researchers who are expert in oral flora and HIV, so we’ll be quite interested in working with them to find out how oral health might influence the new replication pathway my group has discovered,” added Dr. Levy.

http://www.newsfix.ca/2013/11/20/new-hiv-1-replication-pathway-discovered-nyu-college-dentistry-researchers/




Offline GoForIt

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  • Posts: 109
Re: HIV-1 replication without integration may help HIV-1 persist in vivo
« Reply #1 on: November 20, 2013, 09:24:06 PM »
“There is intense interest by researchers in the idea that new drugs might be developed to help to completely eliminate the virus from infected individuals,” said Dr. Levy. “We think that the new replication mechanism we have found could provide a target for drugs designed to eliminate infection.

Dr Levy notes, an interesting phenomenon which other researchers have observed is that some bacteria which live in our mouths can stimulate HIV-1 to emerge from its dormant state.

Most interesting part of this article in my opinion...
08/09/2013   Diagnosed WB positive
08/20/2013   CD4-506(28%)  VL-10,800
09/12/2013   CD4-391(28%)  VL-14,900
09/17/2013   Start ART (Truvada & Tivicay)
10/11/2013   CD4-377(26%)  VL-UD
12/20/2013   CD4-590(??%)  VL-UD
03/18/2014   CD4-660(29%)  VL-UD
07/22/2014   CD4-613(29%)  VL-UD
08/01/2014    Start TAF Clinical Trial
10/09/2014   CD4-498(29.5%) VL-UD

Offline YellowFever

  • Member
  • Posts: 163
Re: HIV-1 replication without integration may help HIV-1 persist in vivo
« Reply #2 on: November 21, 2013, 07:19:30 PM »
Reminds me of this line by Phoebe from FRIENDS "Its not just about oral hygiene, I floss to save lives!"
08/2010 HIV- 08/2012 HIV+
10/2012 CD4 415(15%)
04/2013 CD4 457(15%)
10/2013 CD4 520 (20%) VL 650 (wtf?)
02/2014 CD4 410(20%) VL 390 (yay!)
08/2014 CD4 580(?%)

 


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