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Author Topic: cure ever available??  (Read 3961 times)

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Offline mmary10

  • member
  • Posts: 1
cure ever available??
« on: November 17, 2013, 05:44:02 PM »
I was diagnosed 2 years ago and as much asdI'd like to be hopeful that hiv will be cured, I sometimes wonder?
 A few months ago it seems there was several hiv cure projects in the pipeline but then it just disappeared which makes me question my hope :-\

Offline Tadeys

  • Member
  • Posts: 159
Re: cure ever available??
« Reply #1 on: November 17, 2013, 08:53:41 PM »
What disappeared? I think the cure pipeline is stronger then ever...Just go through this forum form the start (2007) and you"ll see that things are really heating up; seems like every 2 weeks or so there is some kind of breakthrough in basic science or clinical trials. The only really "negative news" these last 2 years was the one regarding the reservoirs; and it was'nt really that much news--scientist knew it was bigger then what they have been seeing--, and not really that negative, since now they really know if the cure strategies are working or not.

Things are going to get really interesting from here on. In 2 weeks the HIV reservoir and erradication strategies summit is being held in Miami. Can't wait.

Offline zettainaoru

  • Member
  • Posts: 28
Re: cure ever available??
« Reply #2 on: November 17, 2013, 09:07:23 PM »
yup, this year is brighter than ever.
At least the antibody that makes VL near zero with only monthly injection(pgt121?), will definitely works.
Im sure the side effect near to zero too.

Offline cicero

  • Member
  • Posts: 66
Re: cure ever available??
« Reply #3 on: November 20, 2013, 10:08:50 PM »
HIV is still a relatively "new" disease, though I know for those of us who have it, and especially those who are LTS, and those who have seen loved ones succumb to it with a fatal end, it does seem like its been here for an eternity.

But someone help me out here, and I apologize in advance if I sound ignorant.

This article is about a new approach to a vaccine:  http://shine.yahoo.com/pets/cats-bring-potential-breakthrough-hiv-research-150300748.html

The article makes it sound like if it pans out, it would be cure-like. So, is a vaccine always and only a preventative?  Or is there such a thing as a "treatment vaccine"?
"How could this happen to lovely me?" -Jacqueline Susann

Offline mecch

  • Member
  • Posts: 11,515
  • red pill? or blue pill?
Re: cure ever available??
« Reply #4 on: November 20, 2013, 10:22:25 PM »
I was diagnosed 2 years ago and as much asdI'd like to be hopeful that hiv will be cured, I sometimes wonder?
 A few months ago it seems there was several hiv cure projects in the pipeline but then it just disappeared which makes me question my hope :-\
Hope for what?  Hope for a cure? Or hope for a good life.
You can have a good life without the cure.
My hunch is "the cure" is going to be piece-meal. Some might get it, some might not, won't work for all, etc etc.
Meanwhile.... HAART.  Better and better treatment...
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Tadeys

  • Member
  • Posts: 159
Re: cure ever available??
« Reply #5 on: November 20, 2013, 11:37:31 PM »
Mecch, you are close to publishing your 10,000th post.

About some being cured and others not. Very likely...just look at Hep C. But Hep C cure rates have good through the roof during the past 2/3 years. I think same thing will happen with HIV. But, you also have to remember that the amount of research behind HIV is waaaaay more then the amount of research behind HEP C. Once things get going in the cure department, 100% cure rates will be achieved faster then what has happed with Hep C.

Cicero: YES, preventive and Therapeutic. And I think some vaccines--at least in theory--can be used as both preventine and therapeutic vaccine. But the great majority are either preventive or therapeutic. Not both.



Offline Basquo

  • Member
  • Posts: 3,254
Re: cure ever available??
« Reply #6 on: December 21, 2013, 12:35:48 AM »
There is constant research going on in an effort to find a cure, be it therapeutic or eradicating. I went to Boston last month so they could get some fresh samples of my blood, which I have done before. In January I went there so they could take samples of my guts via upper and lower endoscopy...and they're ready for me to do it again if I'm willing  :o

My point is that I believe in the research and I'm willing and able to take time off from work so that whatever they want to extract, suck out or shave off can further the work that Dr. Walker and all the believers in the world are doing. I have faith that they will one day finagle the next step in HIV medicine...and we've come so far, I have no choice but to believe that it will be some type of cure.

And yes, I say "believe" a lot!

Offline Jmarksto

  • Member
  • Posts: 486
Re: cure ever available??
« Reply #7 on: December 21, 2013, 10:47:21 AM »
There is constant research going on in an effort to find a cure, be it therapeutic or eradicating. I went to Boston last month so they could get some fresh samples of my blood, which I have done before. In January I went there so they could take samples of my guts via upper and lower endoscopy...and they're ready for me to do it again if I'm willing  :o

My point is that I believe in the research and I'm willing and able to take time off from work so that whatever they want to extract, suck out or shave off can further the work that Dr. Walker and all the believers in the world are doing. I have faith that they will one day finagle the next step in HIV medicine...and we've come so far, I have no choice but to believe that it will be some type of cure.

And yes, I say "believe" a lot!

Basquo:

First, a very sincere thank you for your personal contributions to HIV research. I recognize that I am benefiting from all of those that contributed (to the science, clinical trials, activism, etc.) before me.

With regard to believing in the cure -- I too am a big believer.  I think it is my personality type to think of the future and in the larger context.  While I believe, I am also realistic -- there are many challenges ahead. 

One challenge is that the basic science is moving much faster than clinical research.  We are going to need to shift funding from basic science to clinical studies -- which is much easier said than done.  The process of shifting a multi-billion dollar effort will take time. Multi-year grants need to run out before the funding can be redirected, and then the funding may be more logical to go to another organization that has more experience with clinical studies (which may not have experience running grants from the funder....).

Well, that was just a long winded way to say, thanks, I believe too, but it will take time.

Best,
JM
03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45%  VL 25
02/25/14 CD4   792/37%  VL UD
07/09/14 CD4 1004/39%   VL UD

Offline hopeful2101

  • member
  • Posts: 1
Re: cure ever available??
« Reply #8 on: December 22, 2013, 12:20:08 PM »
This is good to read. I'm new to this disease. I've been looking up research on cures since i found out I was positive. I believe as well but I feel like we all need to get together and actually raise some money so we dont have to wait around for funding.

Offline oksikoko

  • Member
  • Posts: 680
  • Writing the congressman again
    • the treatment cascade
Re: cure ever available??
« Reply #9 on: December 23, 2013, 01:42:06 AM »
Cure schmure. Acceptance is bliss.
Code: [Select]
2013-10-03:                ☣ VL (=) undetectable ☣ CD4 (+) 1105
2013-05-23:                ☣ VL (=) undetectable ☣ CD4 (-) 945
2013-02-25:                ☣ VL (-) undetectable ☣ CD4 (+) 1123
2012-12-16: Enter Stribild
2012-11-20: HIV+           ☣ VL (→) 132,683      ☣ CD4 (→) 920
2012-04-01: HIV-
Dates in this signature file conform to ISO 8601. ;-)

Offline Jmarksto

  • Member
  • Posts: 486
Re: cure ever available??
« Reply #10 on: December 24, 2013, 08:45:53 PM »
Cure schmure. Acceptance is bliss.

Acceptance is not dependence on the cure for sure.
03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45%  VL 25
02/25/14 CD4   792/37%  VL UD
07/09/14 CD4 1004/39%   VL UD

Offline elf

  • Member
  • Posts: 607
Re: cure ever available??
« Reply #11 on: January 12, 2014, 02:26:17 PM »
The cure will be available in 2218.  ???
Let's have a Kiki!

Offline YellowFever

  • Member
  • Posts: 162
Re: cure ever available??
« Reply #12 on: January 12, 2014, 09:34:20 PM »
What's in a cure? Does it mean HIV is out of your body? or that HIV is out of your Life? I highly doubt the former will be true, but I'll take the latter as a sign of being cured. In my opinion, anything better (i.e less frequent) than 4-times-a-year shots is as good as a cure. Think of the day you just need to go to the clinic every 3 months to get a jab along with getting your pee sampled for Gonorrhea, anus swabbed for HPV, CD4s counted for HIV and the sordid details of your sex life recorded for good measure. All in a single visit! :)
08/2010 HIV- 08/2012 HIV+
10/2012 CD4 415(15%)
04/2013 CD4 457(15%)
10/2013 CD4 520 (20%) VL 650 (wtf?)
02/2014 CD4 410(20%) VL 390 (yay!)

Offline Battle4Hope

  • Member
  • Posts: 7
Re: cure ever available??
« Reply #13 on: January 13, 2014, 01:52:26 PM »
i wish there could be kind of                   'functional cure' atleast so that the virus would stop replicating and we could be free from daily medication(just a thought) :P

Offline xinyuan

  • Member
  • Posts: 108
Re: cure ever available??
« Reply #14 on: January 13, 2014, 02:11:59 PM »
A couple of pharmaceuticals (at least GSK for sure) are working on once-a-week to once-a-month regimens. Possibly even quarterly.

We're getting there.

Offline helpgrateful

  • Member
  • Posts: 4
Re: cure ever available??
« Reply #15 on: February 17, 2014, 06:02:11 PM »
With so many research going on, when do you think the next breakthrough comes from? I have been reading the Bionor Vacc-4x stuff and some people think it is the closest to a cure. Is that true?

Offline mecch

  • Member
  • Posts: 11,515
  • red pill? or blue pill?
Re: cure ever available??
« Reply #16 on: February 17, 2014, 09:23:04 PM »
With so many research going on, when do you think the next breakthrough comes from? I have been reading the Bionor Vacc-4x stuff and some people think it is the closest to a cure. Is that true?

Hello welcome to the forum.
Are you dealing with the hear and now, while waiting for the cure?
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline helpgrateful

  • Member
  • Posts: 4
Re: cure ever available??
« Reply #17 on: February 17, 2014, 09:51:55 PM »
No, just wondering. Hearing the news that the reservoir is bigger than initial thought kind of worry me about the "Shock and Kill" approach scientist seem to depend on a cure.

Offline zach

  • Member
  • Posts: 1,391
  • not fade away
Re: cure ever available??
« Reply #18 on: February 17, 2014, 11:25:26 PM »
i don't think i'll see a cure in my lifetime. i'd be thrilled to see 100% access to cheaper effective meds with little to no side effects. and i would go happy if i saw a vaccine in my lifetime, just to know we'd be the last ones stinking up the joint. have my doubts on that too though

Offline xinyuan

  • Member
  • Posts: 108
Re: cure ever available??
« Reply #19 on: February 18, 2014, 07:49:53 AM »
HIV is a messy virus. It mutates frequently. Hence, researchers have had such a hard time pinning it.

Even the antibody production from vaccines can't perfectly cover its many variants.

No vaccine to date has been able to provide truly robust protection against HIV, much less a therapeutic option in those like us (though, there are glimmers). We are certainly on the path to developing one, but it'll be a while for the vaccine route to mature.

http://en.wikipedia.org/wiki/Hiv_vaccine


Please do not forget the many other options being explored (inducers such as HDAC inhibitors or prostratrin for the "Shock and Kill" approach, Sangamo's zinc fingers to turn off CCR5, targeted antibodies, gene therapy to produce silencing RNA to shut down or enzymes to cut out HIV segments). Each has its pros and cons.

Still, many are already in human clinical trials!

Overall, I suspect that we'll need better and better understanding and manipulation of immune cell priming / programming to make further progress towards a cure.

 


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