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Author Topic: Bionor Pharma's "Kick, Kill & Boost" Strategy-- Romidepsin Chosen as Kick  (Read 835 times)

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Offline Tadeys

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  • Posts: 159
Oslo 10.09.2013 - Bionor Pharma ASA (OSE: BIONOR) announces that the Company has chosen romidepsin for the planned combination study with Vacc-4x, after considering various HDAC inhibitors (HDACi). Romidepsin is marketed in the US as Istodax® by Celgene Corporation Inc.

The "Kick, Kill" study is planned to be conducted by the HIV research team at
Aarhus University Hospital, led by Prof. Lars Østergaard. Prof.  Østergaard
presented the background and expectations of the study at Bionor Pharma's
Capital Markets Day in June.

"HDAC inhibitors have recently shown the ability to release HIV from the
lymphatic system where the virus hides, and positive data from this new HDAC
inhibitor research will be published shortly" says Prof. Østergaard. He
continues; "The combination of providing Bionor Pharma's T-cell killing vaccine
Vacc-4x, followed by an HDAC inhibitor may represent a new treatment that can
completely or periodically enable patients to forego continuous treatment with
HIV medications, and thereby lead to a Functional Cure. Romidepsin is chosen
because it has proven to be the most effective HDAC inhibitor to release HIV
from virus reservoirs where virus is hiding. We are very positive about this
study which represents a new way to treat HIV, and have expectations that this
can improve the current treatment of HIV".

"Bionor Pharma is excited about the cooperation with the HIV scientists at
Aarhus University Hospital, who are in the forefront within this novel field of
HIV research" says Dr. Anker Lundemose, CEO Bionor Pharma. "Vacc-4x has
previously demonstrated  its ability to induce killing of virus producing cells
by training the immune system, which seems to be essential as soon as an HDAC inhibitor has activated such cells from being dormant in the reservoir".

Bionor Pharma will be the sponsor for the combination study at Aarhus University Hospital, and the plan is to submit the application with study protocol to the Danish Health Authorities by Q4 2013. Bionor Pharma filed patents on the combination of its vaccines with other treatment modalities including IMiD and HDACi earlier this year. The original romidepsin patent has expired.

The execution of the new "Kick Kill & Boost" strategy depends on funding of the
Vacc-4x & HDACi combination trial. To this end, the Company continues to
evaluate various strategic and financial opportunities, and will continue to
update the market on these efforts during H2 2013.

http://www.bionorpharma.com/en/News/2013/Scientific/Bionor+Pharma's+%22Kick,+Kill+%26+Boost%22+Strategy+Advances+-+Romidepsin+Chosen+as+the+%22Kick%22.b7C_wlvMX7.ips

Offline Matts

  • Member
  • Posts: 184
Re: Bionor Pharma's "Kick, Kill & Boost" Strategy-- Romidepsin Chosen as Kick
« Reply #1 on: November 19, 2013, 04:57:38 PM »
I am quite disappointed in the Scandinavians. What a PR-disaster with the Panobinostat trial in the Summer ("HIV cure on the brink" bla bla ). At least they could publish the results before they start a new project. Did it work or not?

Anyway, I wish Ole Soogard and Bionor the best for the future. If Istadax doesn't work then it's over for Bionor and Aarhus regarding to HIV. It is 1000-20000 fold stronger than SAHA. Maybe it will be the breakthrough :)

http://www.catie.ca/en/treatmentupdate/treatmentupdate-196/hiv-cure-research/promise-romidepsin
http://clinicaltrials.gov/ct2/show/NCT01933594
http://www.isheid.com/presentations/vendredi/12-30/geleziunas/Geleziunas.pdf
http://www.thebodypro.com/content/71626/the-promise-of-romidepsin.html
tivicay/kivexa

 


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