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Author Topic: Is HIV cure possible?  (Read 1176 times)

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Offline Hoyland

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  • Posts: 70
Is HIV cure possible?
« on: November 01, 2013, 10:56:41 PM »
A video of the town hall forum sponsored by CIRM.

http://www.youtube.com/watch?v=7fYU9sg9aBM#t=4193

Offline Dr.Strangelove

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  • Posts: 206
Re: Is HIV cure possible?
« Reply #1 on: November 02, 2013, 09:57:49 AM »
In the last slide (around 1:16:50) they say:
Quote
Monotherapy is likely not sufficient to prevent resistance
Do I understand correctly, that this means the Calimmune approach will not be a standalone solution but will need to be bundled with another approach?

What's encouraging though is that they seem to have much long-term data on animals to show that it's safe.

Offline Tadeys

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  • Posts: 159
Re: Is HIV cure possible?
« Reply #2 on: November 02, 2013, 10:49:08 AM »
Thanks for the video. Part 2--Q&A--was also great. Don't know if its because all the scientists that spoke were so optimistic about curing people, but this is one of the best videos I have seen thus far on the topic. Thank you California for making this happen!


About monothery. Dont know what to say. We have Callimune's approach and  sangamo's approach. I think that by Callimune inserting two more (?) genes to the mix they were thinking about resistance issues. That is why I have my "money" with Callimune and not Sangamo. Besides, Calimmunes RNAii is superior to zinc fingers.

Offline freewillie99

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Re: Is HIV cure possible?
« Reply #3 on: November 02, 2013, 04:16:22 PM »
In the last slide (around 1:16:50) they say:Do I understand correctly, that this means the Calimmune approach will not be a standalone solution but will need to be bundled with another approach?


I believe Mr. Breton's comment is in reference to Cal-1 (their gene therapy approach) having two synergistic entry inhibitors, one to block attachment and one for fusion, vs. just one.  From all I've read about their work, it's mean to be a standalone solution.  Whether or not it ultimately requires an adjunct therapy to purge the reservoirs (for example) will be interesting to see.
Beware Romanians bearing strange gifts

Offline Hoyland

  • Member
  • Posts: 70
Re: Is HIV cure possible?
« Reply #4 on: November 02, 2013, 09:17:22 PM »
On Nov 15 Dr Symonds of Calimmune will be providing an update on the company's trial to an audience in Australia. The company has close links with Johnson & Johnson in Australia - they share a lab - and it will be interesting to see if the results thus far inspire J&J to take a greater interest in Cal-1.

It is likely that the presentation will be posted on-line.

 


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