Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
September 23, 2014, 12:48:30 PM

Login with username, password and session length


Members
Stats
  • Total Posts: 639860
  • Total Topics: 48575
  • Online Today: 220
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Scientists identify molecular signals that rouse dormant HIV infection  (Read 708 times)

0 Members and 1 Guest are viewing this topic.

Offline Tadeys

  • Member
  • Posts: 159


Perhaps the single greatest barrier to curbing the spread of HIV/AIDS is the dormant, or "latent," reservoir of virus, which is out of reach of even the most potent medications. But now, scientists at the Gladstone Institutes have uncovered new clues that may help researchers awaken HIV from its slumber—laying the foundation for purging all trace of the virus, and for one day finding a cure for the more than 34 million people worldwide living with HIV/AIDS.

In a paper being published today in PLOS One, researchers in the laboratory of Gladstone Investigator Warner C. Greene, MD, PhD, have uncovered the molecular signals that guide the activation of latent HIV. Specifically, they showed how molecular crosstalk between calcium and an enzyme called calcineurin, along with a molecule called prostratin, switch on members of the NF-κB family of proteins—thereby activating latent HIV. These findings point to a new strategy of artificially activating HIV—a process that experts believe is key to flushing out all evidence of infection and developing a cure for HIV/AIDS.

http://medicalxpress.com/news/2013-10-scientists-molecular-rouse-dormant-hiv.html

Offline Mishma

  • Member
  • Posts: 190
    • Marquis de Vauban
Re: Scientists identify molecular signals that rouse dormant HIV infection
« Reply #1 on: November 02, 2013, 05:03:42 PM »
Good thing too because they now estimate our reservoirs to be at least 60% larger than previously thought. I am flabbergasted that this hasn't been determined earlier with PCR and Histology.

A cure is one thing estimating the "enemies strength," is something you do at the beginning.


http://www.hiv-reservoir.net/index.php/the-news/432-mechanisms-of-hiv-persistence.html
2016 CD4 25% UD (less than 20). 27+ years positive. Isentress, Truvada, Acyclovir, Clonazepam, Zolpidem, Bupropion, Lisinopril, Pravastatin, Quetiapine, Doxcycline, Testosterone, Suatriptan/Naproxen, Restasis, Dorzolamide, Latanoprost, Asprin, lortab, Levothyroxine, Fioricet, Restasis, Triamclinolone, Nitrostat.

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.