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Author Topic: GeoVax Receives Notice of Patent Allowance for DNA/MVA Vaccine for HIV/AIDS  (Read 1161 times)

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Offline GoForIt

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http://www.marketwatch.com/story/geovax-receives-notice-of-patent-allowance-for-dnamva-vaccine-for-hivaids-2013-10-07?reflink=MW_news_stmp

 ATLANTA, GA, Oct 07, 2013 (Marketwired via COMTEX) -- GeoVax Labs, Inc. (otcqb:GOVX), a biotechnology company developing preventive and therapeutic HIV vaccines, today announced that it has received a Notice of Allowance from the U.S. Patent and Trademark Office (USPTO) for patent application U.S. 10/336,566 entitled, "Compositions and Methods for Generating an Immune Response." The patent, exclusively licensed from Emory University and the U.S. Government, broadly covers compositions, methods, and uses of the GeoVax's DNA/MVA vaccine in eliciting cellular and humoral immune responses to an HIV antigen.

The allowed claims pursuant to the patent cover advances in the DNA construct portion of GeoVax's vaccine. The DNA construct forms the priming vaccine in the GeoVax HIV vaccine regimen and is followed by boosting administrations made up of a modified vaccinia Ankara (MVA) construct. Preclinical studies in primates have shown that simian analogs of GeoVax's DNA/MVA vaccine provide up to 78% per exposure protection against SIV251, a highly virulent strain of simian immunodeficiency virus. Phase 1 testing in humans is ongoing in a trial sponsored by the HIV Vaccine Trials Network, with plans for Phase 2 initiation in 2014.

"This patent is key to the commercialization of our DNA/MVA HIV vaccine technology," said Robert T. McNally, PhD, President and CEO of GeoVax. "We are pleased that the USPTO has confirmed that the claims in our patent application are patentable over the prior art of record."

About GeoVax's Technology GeoVax's unique, two component vaccine, a recombinant DNA and a recombinant modified vaccinia Ankara (MVA), is designed to stimulate both anti-HIV T cell and anti-HIV antibody immune responses. GeoVax's DNA and MVA vaccines are used in a prime/boost protocol in which priming is done with the DNA and boosting with the MVA. Both the DNA and MVA express the three major proteins of the AIDS virus: Gag, Pol, and Env, and produce non-infectious virus-like-particles. GeoVax's vaccines are unique in expressing virus-like particles that display the trimeric membrane bound form of the HIV-1 envelope glycoprotein. In GeoVax's second generation vaccine, the DNA prime co-expresses GM-CSF with the virus-like particles, delivering a normal human protein that stimulates immune responses to the site of vaccination. All preventative Phase 1 human clinical trials conducted to date tested various combinations and doses of the DNA and MVA vaccines, their ability to raise anti-HIV humoral (antibody) and cellular (cytotoxic T cell) immune responses, as well as the vaccines' safety. For more information, please visit www.geovax.com.
08/09/2013   Diagnosed WB positive
08/20/2013   CD4-506(28%)  VL-10,800
09/12/2013   CD4-391(28%)  VL-14,900
09/17/2013   Start ART (Truvada & Tivicay)
10/11/2013   CD4-377(26%)  VL-UD
12/20/2013   CD4-590(??%)  VL-UD
03/18/2014   CD4-660(29%)  VL-UD
07/22/2014   CD4-613(29%)  VL-UD
08/01/2014    Start TAF Clinical Trial
10/09/2014   CD4-498(29.5%) VL-UD
11/06/2014   CD4-600(30.2%) VL-UD

 


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