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Author Topic: TB Testing  (Read 719 times)

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Offline bufguy

  • Member
  • Posts: 161
TB Testing
« on: October 12, 2013, 06:23:42 PM »
When I was first diagnosed HIV+ I was given a PPD test for TB which was non reactive. A few years later I was given a quantiferon test which was reactive. The followup chest x-ray was clear and we began discussion of treatment for latent TB. I stalled and a year and later asked for another test...This time it was negative. I then participated in a clinical trial studying the interaction of a TB med with patients on Atripla. Their screening included another quantiferon test and a chest x-ray...both negative. Six months later as part of my routine labs I tested positive again on the quantiferon test... Diagnosed HIV+ 5 years ago, on atripla, consistently undetectable, CD4 over 1000. They say its not worth testing anymore, yet offered me the antibiotic regimen...I've declined of course...Ver frustrating...I don't want to do a 6 month regimen of INH...Any insights fro anyone here?
5/29/08 confirmed HIV+
6/23/08 Vl 47500  CD4 511/29% CD8 .60
start atripla
8/1/08 Vl 130  CD4 667/31% CD8 .70
9/18/08 Vl un  CD4 not tested
12/19/08 Vl un CD4 723/32% CD8 .80
4/3/09 Vl un CD4 615/36% CD8  .98
8/7/09 vl un CD4 689/35% CD8 .9
12/11/09 vl un CD4 712/38% CD8 .89
4/9/10 vl un CD4 796/39% CD8 1.0
8/20/10 vl un CD4 787/38% CD8 1.0
4/6/10 vl un CD4 865/35% CD8 .9
8/16/10 vl un CD4 924/37% CD8 1.0
12/23/10 vl un CD4 1006/35% CD8 .9
5/2/10 vl un CD4 1040/39% CD8 .9
8/7/13 vl un CD4 840/39% CD8 .9

Offline Valmont

  • Member
  • Posts: 332
Re: TB Testing
« Reply #1 on: October 22, 2013, 11:33:25 PM »
Hi...

I cannot help you much because I also need some help, Im in the same situation, have high CD 4 but my last PPD went back positive (last two years it was not reactive).  X-ray went back good.  Im now in Canada but come from a endemic country.  It is more tan possible that Ill have to start the treatment.  For now Im waiting some more test results to exclude completely it is active...

Anyway, I think it is important to start early, in latente phase, when tuberculosis is sleeping, to clear it completely.  Once you have it, you are exposed to develop active tuberculose in any moment and particularly if your defenses decrease for any reason.  For sure, it is a desease that is very slow to develop, but for my onw, I would not play with it...  Personnally Im thinking about it...

In my case, I also think this sucks and I feel resigned.  I you appreciate to read any feedback in regard to people that used this kind of antibiotic for so long...
Apr 2011: Diagnotized
Jun 2011: CD4: 504  VL: 176.000
Dic 2011: CD4: 714  VL: 95.000
May 2012: CD4: 395 VL: 67.000
Jun 2012: CD4: 367
Agu 2012: Starting Emtricitabine 200 mg / Tenofovir 300 mg and Efavirenz 600 mg (2 pills) different brands or VIRADAY/ATRIPLA/Mylan....
Sep 2012: VL: 138
Dic 2012: CD4: 708 VL: <34  %CD4: 32%
Jan 2013: CD4: 707 VL: <20
May 2013: CD4: 945 VL: <34 %CD4: 33%
Agu 2013: CD4: 636 VL: <34 %CD4: 50%
Dic 2013: Latent TB, started Isoniazid

Offline bufguy

  • Member
  • Posts: 161
Re: TB Testing
« Reply #2 on: October 26, 2013, 11:29:43 AM »
My issue is that I'm not convinced I'm infected...I think the test is faulty...I've been tested numerous times and even my docs aren't sure. In fact they are starting to think the test is faulty. I don't want to go on 6-9 month of antibiotics
5/29/08 confirmed HIV+
6/23/08 Vl 47500  CD4 511/29% CD8 .60
start atripla
8/1/08 Vl 130  CD4 667/31% CD8 .70
9/18/08 Vl un  CD4 not tested
12/19/08 Vl un CD4 723/32% CD8 .80
4/3/09 Vl un CD4 615/36% CD8  .98
8/7/09 vl un CD4 689/35% CD8 .9
12/11/09 vl un CD4 712/38% CD8 .89
4/9/10 vl un CD4 796/39% CD8 1.0
8/20/10 vl un CD4 787/38% CD8 1.0
4/6/10 vl un CD4 865/35% CD8 .9
8/16/10 vl un CD4 924/37% CD8 1.0
12/23/10 vl un CD4 1006/35% CD8 .9
5/2/10 vl un CD4 1040/39% CD8 .9
8/7/13 vl un CD4 840/39% CD8 .9

Offline tednlou2

  • Member
  • Posts: 4,819
Re: TB Testing
« Reply #3 on: October 27, 2013, 03:35:23 PM »
I thought I read the blood test did have an issue with false-positives??  I will have to look for those articles again.  It seems it was a problem during a certain time frame, due to bad batches. 

I do remember this article that says blood tests should not be used, due to errors in false-negatives as well as false-positives. 

http://www.who.int/mediacentre/news/releases/2011/tb_20110720/en/

Offline bufguy

  • Member
  • Posts: 161
Re: TB Testing
« Reply #4 on: October 28, 2013, 09:21:09 PM »
Thank You for that link...I will share it with my Doctor
5/29/08 confirmed HIV+
6/23/08 Vl 47500  CD4 511/29% CD8 .60
start atripla
8/1/08 Vl 130  CD4 667/31% CD8 .70
9/18/08 Vl un  CD4 not tested
12/19/08 Vl un CD4 723/32% CD8 .80
4/3/09 Vl un CD4 615/36% CD8  .98
8/7/09 vl un CD4 689/35% CD8 .9
12/11/09 vl un CD4 712/38% CD8 .89
4/9/10 vl un CD4 796/39% CD8 1.0
8/20/10 vl un CD4 787/38% CD8 1.0
4/6/10 vl un CD4 865/35% CD8 .9
8/16/10 vl un CD4 924/37% CD8 1.0
12/23/10 vl un CD4 1006/35% CD8 .9
5/2/10 vl un CD4 1040/39% CD8 .9
8/7/13 vl un CD4 840/39% CD8 .9

 


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