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Author Topic: "Tre recombinase" update  (Read 7105 times)

0 Members and 1 Guest are viewing this topic.

Offline leit

  • Member
  • Posts: 236
"Tre recombinase" update
« on: June 24, 2008, 04:30:19 PM »

Offline fortuneseeker

  • Member
  • Posts: 16
Re: "Tre recombinase" update
« Reply #1 on: June 24, 2008, 07:31:41 PM »
Hope this come out ASAP in clinical test..
 :)

Offline bimazek

  • Member
  • Posts: 781
Re: "Tre recombinase" update
« Reply #2 on: June 24, 2008, 09:30:50 PM »
wow that is great
esp. since he said in video there are already transgetic animals with tre recombinase and they dont have problems
meaning they can add that to humans and may not cause problems

watch all the segments esp. 3,4, 5 of video above
etc
also there is more here
http://www.jove.com/index/details.stp?ID=791
this video is amazing the german PhD guy says that they breed tre recombinase enzymes just like one would breed animals, you pick progeny that you want and then you make new versions of the enzyme just like pups
more evolution cycles -- evolving tre enzyme
« Last Edit: June 24, 2008, 09:41:11 PM by bimazek »

Offline Matts

  • Member
  • Posts: 223
Re: "Tre recombinase" update
« Reply #3 on: September 27, 2013, 09:52:04 AM »
It seems to work in humaniced mice so far:

"Highly Significant Antiviral Activity of HIV-1 LTR-Specific Tre-Recombinase in Humanized Mice

Abstract
Stable integration of HIV proviral DNA into host cell chromosomes, a hallmark and essential feature of the retroviral life cycle, establishes the infection permanently. Current antiretroviral combination drug therapy cannot cure HIV infection. However, expressing an engineered HIV-1 long terminal repeat (LTR) site-specific recombinase (Tre), shown to excise integrated proviral DNA in vitro, may provide a novel and highly promising antiviral strategy. We report here the conditional expression of Tre-recombinase from an advanced lentiviral self-inactivation (SIN) vector in HIV-infected cells. We demonstrate faithful transgene expression, resulting in accurate provirus excision in the absence of cytopathic effects. Moreover, pronounced Tre-mediated antiviral effects are demonstrated in vivo, particularly in humanized Rag2−/−γc−/− mice engrafted with either Tre-transduced primary CD4+ T cells, or Tre-transduced CD34+ hematopoietic stem and progenitor cells (HSC). Taken together, our data support the use of Tre-recombinase in novel therapy strategies aiming to provide a cure for HIV......

more:
http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003587

http://tu-dresden.de/aktuelles/news/tre-rekombinase/newsarticle_view (german)
tivicay/kivexa

 


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