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Author Topic: bit225 as a component of cure strategy?  (Read 664 times)

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Offline crimbles08

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bit225 as a component of cure strategy?
« on: August 12, 2013, 11:15:11 AM »
Hi all, new here. Just wanted to highlight some incredible work by the biotron company in australia with a compound called bit225. It is a viroporin inhibitor which is like a molecule channel used to convey molecules between cells. It also has something to do with the VPU gene of hiv. It also inhibits hep C and was recently clinically trialled and had a 100% hep C cure rate when added to existing approved treatments.

The exciting thing about bit225 is that it works against macrophage tropic virus and since it is a small molecule it can cross the brain-blood barrier. It has been found that macrophage tropic virus in the brain is a source of reservoir replenishment an has a long half life. bit225 may be crucial in the cure effort since it can block replication in the brain an central nervous system. It may also be a potential treatment for hiv related dementia.

I never hear about bit225 on forums or hiv website news sites and i'm surprised. It might be the key to the cure. Here is a link to a paper describing the importance of macrophage tropic virus.. which current antiretrovirals do not have any effect upon: http://www.med.unc.edu/infdis/news/distinct-aids-viruses-found-in-cerebrospinal-fluid-of-people-with-hiv-dementia

bit225 is going into a phase 2b trial for hiv an into phase 3 for hepatitis c. I expect it to reach market. Hopefully soon, perhaps within a year or two? Hope this interests you all. thanks :)
Contracted HIV ~April 2008
Tested ~June 2008 CD4 310 (13%) VL 510,000
Detuned assay confirmed recent seroconversion July '08
Treated ~September 2008 Atripla
Tested ~October 2008 CD4 410 VL ~1000
Tested ~December 2008 CD4 430 VL UD
2009 Average CD4 ~ 500
Switched september 2009 to Raltegravir + Truvada
2010 Average CD4 ~ 560
2011 Average CD4 ~ 620
2012 Average CD4 ~ 660
2013 CD4 results: 730, 820 and 760 ~33%
September 2013 is 5 years meds anniversary

 


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