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Author Topic: HIVBr18 therapeutic vaccine to begin tests in rhesus monkeys  (Read 1425 times)

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Offline Cosmicdancer

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  • Posts: 150
HIVBr18 therapeutic vaccine to begin tests in rhesus monkeys
« on: August 08, 2013, 12:02:59 AM »
I'm not sure if a thread about this Brazilian vaccine trial already exists, but I didn't see one.  Tests in rhesus monkeys are planned for later this year.

http://www.hivplusmag.com/case-studies/research-breakthroughs/2013/08/06/scientists-may-have-created-first-hiv-vaccine

Scientists May Have Created the First HIV Vaccine

Years of testing follow, but if all works out, this new vaccine won't cure those with HIV, but will stop them from transmitting it to anyone else.

BY DAVID ARTAVIA AUGUST 06 2013 6:24 PM ET

Brazilian scientists announced that they will begin testing a new HIV vaccine on monkeys later this year. The vaccine works by maintaining a viral load so low that will keep an HIV-positive person from developing an immunodieficiency and transmitting the virus to an uninfected person. Even though the vaccine will not totally rid the virus from an infected patient, it is expected to stop transmission between an infected and uninfected person, and may also lead to further understanding of new ways to stall HIV's progression in people who are positive.
 
The HIVBr18 vaccine has been 12 years in the making by a team led by Edecio Cunha Neto, Jorge Kalil, and Simone Fonseca from the medicine faculty of the University of Sao Paulo, Brazil. According to São Paulo State Research Foundation (which also is funding the study), a colony of rhesus monkeys will be used for the clinical trial because not only do they have similar immune systems as humans, but they're susceptible to Simian Immunology Virus (SIV), which is believed to have been the catalyst of HIV when it first crossed the species plateu.
 
"Our goal is to test various immunization methods to select the one capable of inducing a stronger immunological response and thus be able to test it on humans," Neto said, according to the Research Foundation.
 
The monkey trials are expected to last two years and once it is over, with adequete funding, scientists hope to begin the first clinical trials of HIVBr18 in humans.

Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
June, 2008 - undetectable, 612 cd4
January, 2009 - undetectable, 670 cd4
May, 2009 - undetectable, 593 cd4
Sept, 2009 - 83 vl, 763 cd4, 34%
Dec, 2009 - undetectable, 889 cd4, 32%
April, 2010 - undetectable, 860 cd4, 31%
October, 2010 - undetectable, 800 cd4, 38%
April, 2011 - undetectable, t-cell test not done
October, 2011 - undetectable
April, 2012 - undetectable, 850 cd4, 39%
November, 2012 - undetectable, 901 cd4, 41%
April, 2013 - undetectable, 846 cd4, 36%
October, 2013 - undetectable
May, 2014 - undetectable, 784 cd4, 48%

 


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