Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
July 23, 2014, 01:17:54 AM

Login with username, password and session length


Members
Stats
  • Total Posts: 631519
  • Total Topics: 47804
  • Online Today: 244
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: More on,....The Detrimental Effects Of Inflammation Due To Intestinal Bacteria O  (Read 2679 times)

0 Members and 1 Guest are viewing this topic.

Offline J.R.E.

  • Member
  • Posts: 7,093
  • Joined Dec-2003 Living positive, since 1985.



http://www.medicalnewstoday.com/releases/263198.php


The Detrimental Effects Of Inflammation Due To Intestinal Bacteria On HIV Patients

Article Date: 12 Jul 2013 - 1:00 PDT

    

A new study of HIV infection by UC San Francisco researchers points to changes in intestinal bacteria as a possible explanation for why successfully treated HIV patients nonetheless prematurely experience life-shortening chronic diseases.

These changes in gut bacteria may perpetuate inflammation initially triggered by the body's immune response to HIV, according to the study, reported online in the journal Science Translational Medicine.

In recent years, such persistent inflammation has been proposed as a cause of the early onset of common chronic diseases found in HIV patients, who now can live for decades without immune system destruction and death due to infection, thanks to lifelong treatment with antiretroviral drugs. Likewise, in the general population, ongoing inflammation has been linked in some studies to chronic conditions such as heart disease, dementia and obesity.

Studies have shown that inflammation is induced by HIV in both treated and untreated patients, and is associated with - and possibly causes - disease in both, according to Joseph M. McCune, MD, PhD, chief of the Division of Experimental Medicine at UCSF and a senior author of the study. McCune has been investigating the causes of chronic inflammation in HIV-infected patients and has treated patients with HIV for more than three decades.

"We want to understand what allows the virus to persist in patients who have HIV disease, even after treatment," he said. "In this study, we see that bacteria in the gut may play a role."

The study was initiated by Ivan Vujkovic-Cvijin, a graduate student working in McCune's lab in collaboration with Susan Lynch, PhD, an associate professor in the Division of Gastroenterology at UCSF and an expert on the human microbiome, the collection of microbes the live in and on the human body. Researchers estimate that humans have about ten times as many bacterial cells as human cells, and earlier studies have demonstrated that some of the microbes found within the intestines are able to drive immune responses, Lynch said.

"We thought the gut microbiome might be different in HIV-infected individuals, and that the high degree of immune activation in the patients might be associated with and possibly due to the presence of specific members of the bacterial community," Lynch said.

Vujkovic-Cvijin identified bacterial species in biopsied patient samples by tracking a gene that is distinct among different bacterial species. Working with co-first author, Richard Dunham, PhD, a UCSF postdoctoral fellow, he also tracked markers of inflammation in the blood.

The researchers compared seven untreated HIV patients, including six with active infection and one long-term patient who never developed AIDS; 18 HIV patients in whom ongoing drug treatment had reduced HIV in the blood to undetectable levels; and nine uninfected individuals matched for other health risks. The patients are part of a group being monitored through ongoing UCSF research led by UCSF Steven Deeks, MD, and Jeffrey Martin, MD, MPH, at San Francisco General Hospital and Trauma Center.

"We found that HIV-infected people have a very different gut microbiome than people who are uninfected," Vujkovic-Cvijin said. "In particular, infected people harbor more bacteria that can cause harmful inflammation, like Pseudomonas, Salmonella, E. coli, and Staphylococcus."

The degree to which normal bacterial communities in the colon were disrupted corresponded to the levels of an inflammatory molecule, IL-6, in the blood, and also to the production of an enzyme called indoleamine 2,3-dioxygenase. The enzyme can impair the gut's ability to function as a barrier, thereby allowing bacteria and molecules produced by bacteria to enter the body to fuel even more inflammation. Species of bacteria that can mimic the action of this enzyme also were more abundant in HIV-infected participants, Vujkovic-Cvijin found.

The researchers do not believe that there is a single bacterial species responsible for disrupting the integrity of the gut nor do they propose a specific probiotic bacterial treatment to restore a healthy gut. Nonetheless, Lynch said, manipulating microbial populations is a promising idea.

"It appears that changes in the microbiome perpetuate a vicious cycle that drives inflammation in HIV-infected patients," she said. "We are considering a restoration ecology approach to restore appropriate microbial colonization patterns and healthy functioning of the gut microbiome."

McCune believes that inflammation may also play a role in maintaining the persistence of HIV, even in those with no circulating virus in the bloodstream. "Our dream is to be able to make the virus go away, allowing HIV-infected people to lead longer lives without the need for life-long therapy," he said. "Perhaps restoring the microbiome to normal will be one strategy to make that happen."




Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 12.5mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


 In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started my first  HAART regimen  on October 24th,03.

 As of 6/4/14,  t-cells are at 423, Viral load <40

 Current % is at 13% 

  
 62 years young.

Offline elf

  • Member
  • Posts: 596
Melatonin can help, it makes IL-6 go down.  ;)
Let's have a Kiki!

Offline oksikoko

  • Member
  • Posts: 680
  • Writing the congressman again
    • the treatment cascade
This was covered on Youreka Science in case anyone likes the format. It's not many days you read or hear about dysbiosis twice...

http://www.youtube.com/watch?v=tsPUUCS90LY&feature=player_embedded

Watch it on double speed and she really takes off.

Lee
Code: [Select]
2013-10-03:                ☣ VL (=) undetectable ☣ CD4 (+) 1105
2013-05-23:                ☣ VL (=) undetectable ☣ CD4 (-) 945
2013-02-25:                ☣ VL (-) undetectable ☣ CD4 (+) 1123
2012-12-16: Enter Stribild
2012-11-20: HIV+           ☣ VL (→) 132,683      ☣ CD4 (→) 920
2012-04-01: HIV-
Dates in this signature file conform to ISO 8601. ;-)

Offline buginme2

  • Member
  • Posts: 2,834
I wonder how, if at all, probiotics would affect this process.

Online tednlou2

  • Member
  • Posts: 4,758
This reminded me of an article I just read about probiotics. 

http://www.thebody.com/content/72044/can-bugs-increase-cd4-cells.html

Offline Matts

  • Member
  • Posts: 205
maybe the destroyed gut after acute infection is the biggest problem for the poz at all. It was not nice what I read about it. We all could need a stool transplant´:)

http://en.wikipedia.org/wiki/Fecal_bacteriotherapy

A Google translated article from a european Radio interview:

"The microbes in the gut provide a wide variety of molecules ago. If you examine a blood sample, then you can find all of these metabolites. Traveling through the body, and some of them even reach the brain., The effect of the substances is still largely unknown. Clear but is this diversity of substances affect the whole body. "[...]

"We found in HIV patients, many bacteria from the group of proteobacteria, including many pathogenic bacteria. Salmonella, certain E. coli and Pseudomonas species addition, we often found staphylococci same time, some bacteria belonging to a healthy intestinal flora were. .. underrepresented especially Bacteroides bacteria We know people who have too few of these bacteria, often suffer from chronic inflammation of the intestine, for example. "What causes the overgrowth in the gut, is still unclear. [...]

"Perhaps it is this vicious cycle break, the results from this constant ignition pulse when we restore a normal colonization of the intestine. Probably would live HIV patients then longer and better. We could thus perhaps prevent their vessels, ten, 15 years earlier than in healthy calcify. "

And so prevent heart attack and stroke, a common problem - even in HIV-infected patients. As the bacteria-life community can be altered favorably in the intestine, is still open. Would be possible to try to colonize the intestine completely new - with a stool transplant from a healthy donor. People with an intestinal infection with Clostridium difficile dangerous bacteria have been treated with this method, says Tobias Goeser of the University Hospital of Cologne. [...]

But if the intestinal flora can also fix problems in HIV-infected so no one can say today."

tivicay/kivexa

Offline OneTampa

  • Member
  • Posts: 2,092
  • "Butterflies are free."
This is a very intriguing post especially the fecal bacteria transplant.
"He is my oldest child. The shy and retiring one over there with the Haitian headdress serving pescaíto frito."

Offline Ann

  • Administrator
  • Member
  • Posts: 28,134
  • It just is, OK?
    • Num is sum qui mentiar tibi?
Stool transplant? Ew.

Matts, it sounds as though the original European radio interview was in German ("says Tobias Goeser of the University Hospital of Cologne") - could you provide a link so maybe someone here who speaks German can give us a better translation of the key points you quoted? Some of it makes no sense. (for example: "We could thus perhaps prevent their vessels, ten, 15 years earlier than in healthy calcify")

One should always provide a link to any source quoted here, particularly here in the Research forum.

Thanks! :)

By the way, I've found http://www.freetranslation.com/ generally gives a MUCH better translation of most languages than any other site on the internet.
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Matts

  • Member
  • Posts: 205
The original link from DeutschlandRadio is:
http://www.dradio.de/dlf/sendungen/forschak/2174667/

Has somebody experience with medicinal clay? I use it sometimes, but I dont know if it really can absorb unwanted bacteria as the alternative medicine claims.
tivicay/kivexa

Offline buginme2

  • Member
  • Posts: 2,834
Stool transplant? Ew.


Stool transplants recently made big headlines.  People who are suffering from C Diff, which can be brought on by heavy antibiotic use, have seen remarkable success by using a stool transplant. 

Stool from a healthy person is transplanted into someone else with untreatable C Diff and the stool recolonizes the health bacteria in the intestine.  In many cases one transplant cures the person.

http://phenomena.nationalgeographic.com/2013/07/10/a-living-drug-cocktail/

So, it does raise the question, could a fecal transplant assist in returning an HIV positive persons gut flora back to normal? A question for a study perhaps.



 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.