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Sign-On Letter to Gilead

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You can sign on a letter from the Treatment Action Group, Project Inform and HIV-i Base to Gilead if You want.

Gilead doesn't plan to release Tenefovir Alafenamide Fumarate (TAF) as a single pill, only as part of TAF-inclusive fixed-dose combinations (FDCs).
"Activists and the scientific community have known about the potential benefits of TAF, over those of tenofovir disoproxil fumarate (TDF), for twelve years; it is disappointing that its clinical development was delayed until the twilight of TDF’s patent protection."

TAF is 5-7 fold more potent than TDF in the target cells with a 90% lower concentration in the blood plasma, because of that it doesnt cause the known TDF related damages in the bones and kidneys.

A stand-alone TAF is especially important for treatment experienced, because it overcomes TDF and NRTI mutations.

thanks Matts! :)

Signed.   :D

Jeff G:
signed .



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