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Author Topic: Two reported cured of HIV in Kenya?  (Read 17867 times)

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Offline Tadeys

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Two reported cured of HIV in Kenya?
« on: May 06, 2013, 12:33:58 PM »
A little more than 30 years ago, when the scope of the HIV/Aids pandemic became public knowledge, an understandable mood of despair settled on the medical community and general public. The disease was considered deadly and seemingly immune to treatments available at the time, but today there is reason for optimism.

In mid 2010, a little girl was born to a woman somewhere in Mississippi in the US. The mother had no pre-natal care and, thus, did not know that she was infected with HIV. A routine test showed she was. Sadly, so was her newborn.

The doctors transferred the baby to University of Mississippi Medical Centre and put her on three antiviral drugs (AZT, 3TC, and Nevirapine) at higher-than-usual dosages, beginning only 30 hours after birth. That swift and strong remedy killed the virus before it could create “hideouts” or “niches” in the child’s immune system.

Months later, doctors announced that even though her blood showed traces of HIV, the virus was not able to replicate or invade other cells. Medics then declared the child “functionally cured”, meaning the virus was in long-term remission.

The Berlin Patient

That, however, was not the only “cure” announced. In 2007, Timothy Ray Brown, popularly known as the “Berlin Patient”, became the first man on record to have been cured of HIV, triggering a flurry of medical trials across the world as researchers believed the therapy could be replicated or modified to treat other patients. Brown’s story is arguably one of the most followed in the realm of HIV research.

Nearer home, a similar trial is being conducted by Dr Simon Barasa Situma of the Technical University of Kenya, formerly Kenya Polytechnic. Dr Barasa has modified the world’s first recorded HIV “cure” and says it has worked effectively on four of his patients and that another 18 currently under observation “are doing well”.

“Consecutive tests show they carry no virus, but we have to monitor them for at least six to 12 months to be sure they are free of HIV,” explained Dr Barasa, a practising pharmacist, during a presentation last week at TM’s Second World Virology and Microbiology Conference in New York.

“I have demonstrated the HIV cure in two people by stopping rapid multiplication of CD4 progenitor cells in the bone marrow, where the HIV virus hides (to avoid) elimination by the immune system and thus achieved the first complete cure without bone marrow transplantation,” Dr Barasa said.

His treatment, he says, is based on the world’s first known cure of HIV, that of Timothy Ray Brown, 47, who was diagnosed with HIV in 1995 and put on ARVs, but in 2006 developed leukaemia (blood cancer) and, for this reason, was given a bone marrow transplant with a rare gene mutation that provides natural resistance to HIV.

His doctor, Gero Hutter, said this resistance seemed to have been transferred to Brown, but Dr Barasa says this was not the case, arguing that the removal of Brown’s bone marrow did it.

“Removing the bone marrow, where the CD4 cells replicate, denied the virus the capacity to replicate and consequently the patient was free of HIV,” says Dr Barasa. Since the new bone marrow was resistant to the virus, the already existing bugs in circulation and from the secondary reservoirs — which include the brain, glands, intestines, and skin — could not create new hideouts, hence the ultimate eradication of the virus.

Bone marrow transplantation is a very expensive, specific, and dangerous procedure, which makes Brown’s treatment impossible to apply to the more than 30 million people with HIV. However, according to Dr Barasa, purging the virus from some specific locations where it seems to hide is the way out.

Treat cancer

Medical doctors using antiretrovirals are able to bring down a patient’s viral load to undetectable levels, but once the patient stops the medication, the viral load goes up again.

“This means there is a reservoir in the body where the virus is hiding and where the ARVs are not able to reach. The hideout is in some parts of the bone marrow. Get rid of this reservoir and, theoretically, you are home and dry,” Dr Barasa says, adding that he has achieved this using a method that comprises the use of a cancer drug (methotraxate) in combination with other agents. Two patients who have undergone the therapy, Dr Barasa adds, have shown no signs of the virus for the past six months.

Methotrexate is used to treat cancer but is indicated to have very serious side effects and should not be used without advice from a competent physician.

“Although the drug is available in local pharmacies on prescription, it must never be used without clear instruction from your doctors,” says Dr Barasa.

The lecturer has since applied for a patent with the Kenya Industrial Property Institute for the treatment process, titled Cure for HIV/Aids Virus.

“Our methodology is simple, safe, acceptable, and cheap, although not yet scientifically validated,” says Dr Barasa in his case study. Even though we could not verify the claims, Dr Barasa says two patients, a man aged 29 and a woman aged 40, both of whom had previously been diagnosed with HIV and put on antiretroviral medication, “are now functionally cured”.

“We treated them with methotrexate, which works by suppressing rapid expansion of the specialised stem cells in the bone marrow, called hematopoietic cells,” he says.

The treatment consists of a combination of agents that are given in a methodology that is tailored to suit individual patients with continuous laboratory monitoring by Pathologist Lancet Kenya Limited, a fully-fledged reference laboratory situated in Nairobi’s Upper Hill area that boasts a wide test menu, including sophisticated molecular tests.

Within two weeks, he says, the patients showed tremendous improvement, healing of symptoms related to HIV/Aids and recorded undetectable viral loads in their blood after eight weeks for the man and 10 weeks for the woman.

Undetectable loads

“They have remained with undetectable levels of viral loads six months after the procedure,” says Dr Barasa who, on the road to this treatment together with his colleagues, regularly sought advice from both Mr Brown and his doctor through email exchanges.

In one such communication they wrote to the cured patient: “We are working diligently here in Kenya to see if we can achieve the same status as you did by interfering with the bone marrow, which is the critical reservoir for the virus.”

Dr Isaac Orina, a neuroscientist and chairman of the Department of Pharmaceutical Technology at Technical University of Kenya, says it is too early to celebrate victory “since the HIV/Aids war is far from over”.

“The disease is still a significant health threat in the world,” says Dr Orina, “but whether it’s going to be a complete cure for HIV or not, the fact remains that functional cure has a huge potential in eradicating the pandemic. A lot of research is, however, needed, and we are closely following Dr Barasa’s work. We hope the university will work with him once the preliminary findings are scientifically validated.”

Dr Orina says what Dr Barasa and other doctors around the world are doing is “very interesting” and can be an important step towards getting rid of the HIV virus.

“The only thing that we need is government support. Most scientists here lack funds to conduct research on such essential health issues,” he concludes.

As he waits for funds, Dr Barasa is holed up in his laboratory, shaking the tree of science.

http://www.africareview.com/Special-Reports/After-Berlin-Man--two-reported-cured-of-HIV-in-Kenya/-/979182/1843388/-/3saq6o/-/index.html


Offline Tadeys

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Re: Two reported cured of HIV in Kenya?
« Reply #1 on: May 06, 2013, 01:34:36 PM »
HIV hoaxs seem to come a lot from Africa, but this doc SEEMS legit. He has worked with the University of North Carolina in the past in trials tied to Kenya using Vorinostat. This article says "he [Dr. Basara] has achieved this using a method that comprises the use of a cancer drug (methotraxate) in combination with other agents. Other agents? Hummmmmmmm. Fingers crossed.

Offline Jeff G

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Re: Two reported cured of HIV in Kenya?
« Reply #2 on: May 06, 2013, 01:39:47 PM »
I will probably be the guy with egg on his face for mocking someone they day a cure is actually found and announced . I have heard it too many times before to even be curious enough to click a link that says aids and cure in the same link .

The newly poz scour the earth for a hope for a cure , I still have that hope too but my energy has shifted from looking for a cure to one of living a happy life with HIV .

Its good we discuss and report these things , it can reveal some ingenious science or a list of charlatans to look out for .   

Offline JazJon

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Re: Two reported cured of HIV in Kenya?
« Reply #3 on: May 06, 2013, 02:34:17 PM »
Sounds great and makes sense but I'd like to see other sources confirm this is real.

http://lmgtfy.com/?q=hiv+methotrexate+cure

If you narrow google search to "news" only, the main link in the Original post is the ONLY one that comes up.   Shouldn't this be announced in more than one place if its legit.
« Last Edit: May 06, 2013, 02:37:14 PM by JazJon »

Offline buginme2

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Re: Two reported cured of HIV in Kenya?
« Reply #4 on: May 06, 2013, 03:29:47 PM »

The newly poz scour the earth for a hope for a cure , I still have that hope too but my energy has shifted from looking for a cure to one of living a happy life with HIV .

I have a severe case of cure fatigue.

Almost on a daily basis there is a post such as this one.  I wonder, are people really putting their hopes in these types of stories?   How sad it is to put faith in the fact that a cure is right around the corner, or there will be a breakthrough "within months."  It reminds me of Linus waiting for the Great Pumpkin. 

The part that gets me a little is that, HIV sucks I am right there with everyone on that and I do wish someday they will develop some magical bean you can take to take the aids away, but I fear that people are putting their hopes in a cure that may never come instead of learning how to live with this successfully.

On a side note, and this may be a good subject for a new thread, but a lot of these so called "cures" sound absolutely dreadful.  Is the cure worse than the disease?  I really don't know how enthusiastic I would be opting for some stem cell transplant or gene therapy when I can live relatively comfortable on Complera or maybe some other longer acting medicine in the future. I don't know if I would take the cure. 

Imagine that, a cure comes out and we all decide to just stay on treatment instead.  That would be a kicker!

Offline sensual1973

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Re: Two reported cured of HIV in Kenya?
« Reply #5 on: May 06, 2013, 04:29:38 PM »
When i saw the word Kenya i stopped reading.
God grant me the serenity to accept the things i can not change.

Offline Jeff G

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Re: Two reported cured of HIV in Kenya?
« Reply #6 on: May 06, 2013, 05:06:46 PM »
I think it was around 1988 I stopped  believing a cure would be around the corner and concentrated on how much damage I could do to my body having fun before Aids did the rest .

I heard about the 3 drug cocktail from a over served customer where I was bartending , he was crying tears of joy and trying to get behind the bar to hug me ... so I had security throw him out . A few days later my doctors confirmed there was indeed a promising 3 drug combo for me to take ... a few days after that I was on them and it was the first time of many that I shit my pants in public .

I'm not trying to Highjack this thread  , its that I feel a little protective of some of the new people here that just now finding their way living with this virus . I dont want them getting their hopes up or spending money on scams , getting hurt .

We had a very sweet intelligent member here that came onto the forum announcing plans to fly thousands of miles for treatments that she was promised would cure her and she was crushed and angry when we had to warn her not to go , shes not been back much since because it left her with hurt feelings .

This is a highjack and I do apologize to the OP , but I just had to say it because some people do get hurt when they read threads like this before they have had time to gain  the experience to be skeptical . 

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #7 on: May 06, 2013, 05:27:29 PM »
When i saw the word Kenya i stopped reading.
Well that's sad.  The point of critical media literacy is to read a text, or watch a report, and judge its merits.  The article says nothing different than all the public relations releases about "cures" from the big players...   

Yes the point is always, show the research please.....   

A few weeks ago I said I would love it and would not be surprised if the "cure" came from some unexpected place - unexpected because its not in the big leagues of scientific research. 

You all know that there are REAL fucking universities in Kenya, in Africa, in most so called "developing" nations around the world.  Jeez! 

Sure there's a history of snake oil in many parts of the world, about HIV or any disease.  But we don't need to completely dismiss news, based on the nation it comes from...   A press release from a legitimate scientist, or a legit university, should be given some advance cred, so at least you read it and ask - where is the proof.  A press release from a legit source, IS NOT THE SAME as an online scam from a "Nigerian Prince", in the often quoted example.. 

« Last Edit: May 06, 2013, 05:45:02 PM by mecch »
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline 2blessed

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Re: Two reported cured of HIV in Kenya?
« Reply #8 on: May 06, 2013, 05:40:52 PM »
A cure will occur within five years...

Offline Tadeys

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Re: Two reported cured of HIV in Kenya?
« Reply #9 on: May 06, 2013, 05:49:59 PM »
Yes, I am new to all this, but I am very skeptical when it comes to an HIV cure. Thats why I used a question mark (?) at the end of the title sentence as opposed to an exclamation mark (!)  And in my reply, I even used SEEMS ( "the doctor SEEMS legit") in capital letters and not the third-person singular present tense of the English language verb "to be"... IS legit....:D    Yes, the "dr" SEEMS legit, meaning he SEEMS to exist. But I smell BS none-the-less.   :)




Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #10 on: May 06, 2013, 05:53:38 PM »
I agree, yours is a good method.  Saying anything that comes out of Kenya must be a scam, is not.
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Jeff G

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Re: Two reported cured of HIV in Kenya?
« Reply #11 on: May 06, 2013, 05:56:23 PM »
Im glad it was posted , it opens up the board to conversation and I never drew an inference that the OP agreed or disagreed with the information .   

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #12 on: May 06, 2013, 05:59:10 PM »
I quoted sensuel1973, not the OP.  ::)
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Jeff G

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Re: Two reported cured of HIV in Kenya?
« Reply #13 on: May 06, 2013, 06:02:19 PM »
I quoted sensuel1973, not the OP.  ::)

How ironic , what I wrote wasn't all about you .  ;)

Offline WillyWump

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Re: Two reported cured of HIV in Kenya?
« Reply #14 on: May 06, 2013, 06:39:01 PM »

I really don't know how enthusiastic I would be opting for some stem cell transplant or gene therapy when I can live relatively comfortable on Complera or maybe some other longer acting medicine in the future. I don't know if I would take the cure. 


Good point.

Because i doubt, although Im hopeful, that the cure will be a one pill "take it and we are done" type of thing.

-W
POZ since '08

Last Labs-
6/3/14 CD4- 736, UD 34%
6/25/13 CD4- 1036, UD,
2/4/13, CD4 - 489, UD, 28%

Current Meds: Prezista/Epzicom/ Norvir
.

Offline buginme2

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Re: Two reported cured of HIV in Kenya?
« Reply #15 on: May 06, 2013, 07:26:19 PM »
Good point.

Because i doubt, although Im hopeful, that the cure will be a one pill "take it and we are done" type of thing.

-W

I read some of these articles that say they would need to do full body radiation and chemotherapy to wipe out your immune system then a gene therapy or stem cell replacement to effect a cure. umm no thank you.

Offline JazJon

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Re: Two reported cured of HIV in Kenya?
« Reply #16 on: May 06, 2013, 08:39:53 PM »
I wonder........
How does Methotrexate Dr Barasa used compare to Busulfan Calimmune is using for pre-conditioning trials?

http://forums.poz.com/index.php?topic=46455.msg587612#msg587612

Offline freewillie99

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Re: Two reported cured of HIV in Kenya?
« Reply #17 on: May 06, 2013, 09:43:24 PM »
I wonder........
How does Methotrexate Dr Barasa used compare to Busulfan Calimmune is using for pre-conditioning trials?

http://forums.poz.com/index.php?topic=46455.msg587612#msg587612

http://clinicaltrials.gov/ct2/show/study/NCT00000834

No results posted.  Strange.
Beware Romanians bearing strange gifts

Offline Rev. Moon

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Re: Two reported cured of HIV in Kenya?
« Reply #18 on: May 06, 2013, 11:36:41 PM »
I read some of these articles that say they would need to do full body radiation and chemotherapy to wipe out your immune system then a gene therapy or stem cell replacement to effect a cure. umm no thank you.

Zackly.  People think that this miraculous "cure" (if it were to actually happen) will be some simple pop-a-pill or get-a-shot-in-yer-booty kinda thing.  So naive.   
"I have tried hard--but life is difficult, and I am a very useless person. I can hardly be said to have an independent existence. I was just a screw or a cog in the great machine I called life, and when I dropped out of it I found I was of no use anywhere else."

Offline leatherman

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Re: Two reported cured of HIV in Kenya?
« Reply #19 on: May 07, 2013, 12:15:58 AM »
I read some of these articles that say they would need to do full body radiation and chemotherapy to wipe out your immune system then a gene therapy or stem cell replacement to effect a cure. umm no thank you.
so far that's the only way a "cure" has been affected. I personally refrain from calling these procedures "cures" as they are actually immune system destruction and replacement procedures. And of course, there are all those messy stats of how often the radiation and chemo cause death. ;) Not to mention years of severe after effects. (the story of Timothy Brown shows that afterwards there are lots of problems/issues just to be able to say that you are HIV-free) If you were dying of lukemia or something it might be worth a last ditch effort (the point the "cured" people have been at so far); but if you're fairly healthy, these procedures have a huge risk factor of death.
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline geobee

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Re: Two reported cured of HIV in Kenya?
« Reply #20 on: May 07, 2013, 12:20:04 AM »
Clinical trial: "A Phase I Study of Methotrexate for HIV Infection"

http://clinicaltrials.gov/show/NCT00000834

Not many details on the trial, just interesting that it's been tried in a Phase I trial.


Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #21 on: May 07, 2013, 10:10:22 AM »
I think we all know HIV can be cured even without my method, at least from the two known cases and the use of post-exposure treatment. Let me be clear, Methotrexate is NOT cure for HIV and no one should attempt to take it for that purpose. I only used it to clear bone marrow reserve of the virus thereby remove a relentless source of infection. But then there are many other reserves in the body that need to be cleared for a total cure otherwise these would re-infect the bone marrow. That is why I talk about other agents that are used in this methodology.
For the doubting Thomases, this is real

Offline Jeff G

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Re: Two reported cured of HIV in Kenya?
« Reply #22 on: May 07, 2013, 11:41:06 AM »
I think we all know HIV can be cured even without my method, at least from the two known cases and the use of post-exposure treatment. Let me be clear, Methotrexate is NOT cure for HIV and no one should attempt to take it for that purpose. I only used it to clear bone marrow reserve of the virus thereby remove a relentless source of infection. But then there are many other reserves in the body that need to be cleared for a total cure otherwise these would re-infect the bone marrow. That is why I talk about other agents that are used in this methodology.
For the doubting Thomases, this is real

Welcome to forum Barasa , It may help if you introduce yourself so new readers can put your thoughts into context . 

What are the other agents you are talking about ?

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #23 on: May 07, 2013, 01:36:51 PM »
I am Dr Simon Barasa Situma the originator of the HIV cure. I started by publishing the theory of viral sequestration as I had unravel led hoping more experts would build on it to rout the virus. You can read it at http://www.ncbi.nlm.nih.gov/pubmed/22267945 Later I developed the methodology myself.

Offline geobee

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Re: Two reported cured of HIV in Kenya?
« Reply #24 on: May 07, 2013, 02:35:32 PM »
Welcome to the forums, Dr. Barasa Situma,

I have two questions --

1. What are the other agents?
2. Has your work been reviewed in any scientific journals? Are there other doctors that can validate your work?

Thank you!

Offline Newguy

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Re: Two reported cured of HIV in Kenya?
« Reply #25 on: May 07, 2013, 10:10:53 PM »
Welcome to the forums, Dr. Barasa Situma,

I have two questions --

1. What are the other agents?
2. Has your work been reviewed in any scientific journals? Are there other doctors that can validate your work?

Thank you!

Did you click on the link he provided? That looks like published peer reviewed work to me. And it has been impressively viewed over 6000 times.

Be well

Offline Dr.Strangelove

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Re: Two reported cured of HIV in Kenya?
« Reply #26 on: May 08, 2013, 07:44:51 AM »
I clicked on that link. It doesn't matter how many people have clicked on it, the question is how often has this work been cited?

That article is not a research paper. It's more of a review-style opinion piece. Dr. Barasa's view on how to tackle HIV. Read the Acknowledgement section...

I have a severe case of cure fatigue.
Me too!

Offline jkinatl2

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Re: Two reported cured of HIV in Kenya?
« Reply #27 on: May 08, 2013, 06:14:32 PM »
Sigh.

That's all I have on the topic.

"Many people, especially in the gay community, turn to oral sex as a safer alternative in the age of AIDS. And with HIV rates rising, people need to remember that oral sex is safer sex. It's a reasonable alternative."

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Welcome Thread

Offline Miss Philicia

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Re: Two reported cured of HIV in Kenya?
« Reply #28 on: May 08, 2013, 06:42:24 PM »
A cure will occur within five years...

They said three years back in 1987. AIDS is a lot of fun.
"I’ve slept with enough men to know that I’m not gay"

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #29 on: May 08, 2013, 07:02:41 PM »
How many threads are going on this now.

I notice that this moment might be another of those times where two seemingly contradictory ways of thinking should be entertained simultaneously.

Its important to consider the wisdom of experienced people in their 40s 50s 60s, and their skeptical approach to each year's cycle of "The Cure is on Hand."

Time passes and passes and passes and things keep improving and improving and improving for HIV+ folks. And also no cure no cure no cure.  But we oldies all know what the challenge was, and all respect the exceptional progess made to meet a very difficult challenge for science.

As an old person I try to be careful to, on the one hand, pass on the war stories and the years of experience, but on the other refrain from pissing on the hope that young people have.  (Not accusing anyone here, but it does happen.)  Its a fine line...   

Imagine being in your early 20's and getting HIV now.  Young people grew up in a different reality, HIV hasn't been the pervasive inevitable killer for quite some time.  Easy to imagine a cure, if the thing is already so well managed.

And anyway, young people are naturally filled with hope, optimism, and ambition.  So remember to value, respect, take some energy from that way of thinking.  Its important to be optimistic and young people do it so well and easily. 

But yeah, a soupcon of sober realism and historical perspective doesn't have to clip the hope.
 
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Jmarksto

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Re: Two reported cured of HIV in Kenya?
« Reply #30 on: May 08, 2013, 07:07:56 PM »
How many threads are going on this now.

I notice that this moment might be another of those times where two seemingly contradictory ways of thinking should be entertained simultaneously.

Its important to consider the wisdom of experienced people in their 40s 50s 60s, and their skeptical approach to each year's cycle of "The Cure is on Hand."

Time passes and passes and passes and things keep improving and improving and improving for HIV+ folks. And also no cure no cure no cure.  But we oldies all know what the challenge was, and all respect the exceptional progess made to meet a very difficult challenge for science.

As an old person I try to be careful to, on the one hand, pass on the war stories and the years of experience, but on the other refrain from pissing on the hope that young people have.  (Not accusing anyone here, but it does happen.)  Its a fine line...   

Imagine being in your early 20's and getting HIV now.  Young people grew up in a different reality, HIV hasn't been the pervasive inevitable killer for quite some time.  Easy to imagine a cure, if the thing is already so well managed.

And anyway, young people are naturally filled with hope, optimism, and ambition.  So remember to value, respect, take some energy from that way of thinking.  Its important to be optimistic and young people do it so well and easily. 

But yeah, a soupcon of sober realism and historical perspective doesn't have to clip the hope.
 

well said...
03/15/12 Negative
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Offline jkinatl2

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Re: Two reported cured of HIV in Kenya?
« Reply #31 on: May 08, 2013, 07:17:09 PM »
What aggravates me is not youthful optimism and hope. It's the lack of critical thinking.

Confusing page view for peer review?

You guys realize that a phase three trial of a promising HIV vaccine (a good friend was enrolled) was summarily halted last week because it simply did not work. At all. That was a phase THREE trial - over a decade in the making, and the ONLY vaccine trial in the works.

Critical thinking =/= pessimism.

"Many people, especially in the gay community, turn to oral sex as a safer alternative in the age of AIDS. And with HIV rates rising, people need to remember that oral sex is safer sex. It's a reasonable alternative."

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Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #32 on: May 08, 2013, 07:34:17 PM »
What aggravates me is not youthful optimism and hope. It's the lack of critical thinking.

Confusing page view for peer review?

You guys realize that a phase three trial of a promising HIV vaccine (a good friend was enrolled) was summarily halted last week because it simply did not work. At all. That was a phase THREE trial - over a decade in the making, and the ONLY vaccine trial in the works.

Critical thinking =/= pessimism.

Believe me, I know all about the critical thinking challenge because I'm a college teacher.  Yes I have info and methods and material to develop critical thinking.  And there are days when I get discouraged by the lack of skill, the lack of interest, and even occasionally just the lazy refusal, even though the skill is there.

Other days, though, I feel the young ones are the brilliant minds around me, and my colleagues a bunch of rigid thinking stiff, one foot in the grave fogies. Fatalistic, cynical, tiring, energy drains...

Anyway, I'm glad some businesspeople, researchers, and young people are preoccupied with the cure, and they are not pessimistic.
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline buginme2

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Re: Two reported cured of HIV in Kenya?
« Reply #33 on: May 08, 2013, 07:48:17 PM »
What pisses me off is not the casual terminology of stating a cure is at hand it by overly optimistic newbies but by doctors and researchers who should know better.

Twice now in a matter of a couple weeks doctors/researchers have thrown around the cure word irresponsibly.  I don't care how confident you are in our research until your theory has been thoroughly tested and REPRODUCED by others you have no business telling the press you are on the brink of a cure. 

Both the researchers in Denmark and this quack in Kenya (yes I said it) should be ashamed of themselves and called out by the research community for how they have handled their press releases.

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #34 on: May 09, 2013, 01:10:40 AM »
"What pisses me off is not the casual terminology of stating a cure is at hand it by overly optimistic newbies but by doctors and researchers who should know better.

Twice now in a matter of a couple weeks doctors/researchers have thrown around the cure word irresponsibly.  I don't care how confident you are in our research until your theory has been thoroughly tested and REPRODUCED by others you have no business telling the press you are on the brink of a cure. 

Both the researchers in Denmark and this quack in Kenya (yes I said it) should be ashamed of themselves and called out by the research community for how they have handled their press releases."

Dont be so hopeless my dear, a cure is  a cure and yes, it is reproducible. I hope to work with a Doc in UK to cure a patient there in less than a month (on skype). When this happens and he shouts then  you will believe. It is nothing out of the ordinary, just logical. More like you could have a toolbox and you cant do a thing on the motor if you don't have the logic. I should have wanted to say cure earlier but it was not easy. Our press is skeptical and eventually to touch it they had to confirm.

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #35 on: May 09, 2013, 02:10:03 AM »
Well its certainly true, member Barasa, that nobody is content with your vague description of what drugs and "other agents" you used.  Since you took the time to join this forum, why don't you explain to us

1) when your research will be published detailing what was used, how it worked, how the eradication has been verified. 

2) if you've already had successful eradication - explain why you or your team can't publish the result for the world to see.  (Is it those patent considerations?  Is it something about the who gets to publish and who doesn't, or the delay it takes to get into a journal?   When exactly did you get these eradication results - very recently?)

In other words, prove it please. Just spell it out.

And good luck with the effort to reproduce it in the UK.
« Last Edit: May 09, 2013, 02:13:02 AM by mecch »
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #36 on: May 09, 2013, 02:43:29 AM »
in the process. Nothing works so fast. We call this preliminary findings which have to be presented then follows proper protocol. It is not even with institutions yet but will move.

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #37 on: May 09, 2013, 06:57:23 AM »
IMO thats an inadequate response to some specific questions.  Not that you owe me a response, of course. IMO - to be taken seriously by thoese institutions whom you want to be, (UK scientists? research journals? pharma?) you'll need to be much more forth-comng and articulate than you have bothered to be here, for example.  Also, if I were you, I would take down that bizarre youtube video with the robot voice. Not helping your image and project, AT ALL! 

I'm as skeptical as others about this whole scenario you are representing.  Maybe a lot is being lost in translation...  So I'll give the benefit of the doubt and say good luck on your project..
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Miss Philicia

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Re: Two reported cured of HIV in Kenya?
« Reply #38 on: May 09, 2013, 08:03:44 AM »

You guys realize that a phase three trial of a promising HIV vaccine (a good friend was enrolled) was summarily halted last week because it simply did not work. At all. That was a phase THREE trial - over a decade in the making, and the ONLY vaccine trial in the works.

Critical thinking =/= pessimism.


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Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #39 on: May 09, 2013, 11:59:42 AM »
Meanwhile, elsewhere in Kenya, a faith-healer/prophet (2 for 1?) played a role in the last Kenyan presidential election.   

This saw the election of the richest man in Kenya, Uhuru Kenyatta (Amherst educated), and who is the son of the Kenya’s “founding father” and former President Jomo Kenyatta.  Also maybe someone who did crimes against humanity by this dirty political games over the years.

Anyway this Prophet is named Prophet Dr. David Owuor.  (I don't know much but what I do know is…) Prophet Dr. is (supposedly) the graduate of prestigious medical schools in Israel and postdoc positions at two U.S. medical/research centres, in molecular genetics and DRUG DEVELOPMENT. 

Anyway he is now a prophet (not sure of what church) and faith-healer who has healed a few dozen (?) HIV+ patients, through faith.

He “acknowledges there is no cure for AIDS” (a credential drug researcher!!!), he can't cure aids, but he has seen people cured by God. (I guess he is a witness and some kind of accelerator of miracles?)

And the point of all that is, if I read the couple weird links I followed, correctly...
The government sent the “state health official” to inspect these “cures” -- so, presumably some sort of credentialed expert – and he reported that the cures are REAL.  (This is all 2013 dears.)

One hand washes the other, the Prophet has assured his followers, that the New President – Uhuru Kenyatta – is “anointed by GOD”.

I’m not making this up.  I didn’t link to the sites because the air is a bit electric in this forum on these topics, and I don’t want to link to anything people would say is denialist. 
« Last Edit: May 09, 2013, 12:19:25 PM by mecch »
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Jmarksto

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Re: Two reported cured of HIV in Kenya?
« Reply #40 on: May 09, 2013, 12:02:08 PM »
What aggravates me is not youthful optimism and hope. It's the lack of critical thinking.

Confusing page view for peer review?

You guys realize that a phase three trial of a promising HIV vaccine (a good friend was enrolled) was summarily halted last week because it simply did not work. At all. That was a phase THREE trial - over a decade in the making, and the ONLY vaccine trial in the works.

Critical thinking =/= pessimism.



There has to be some room between the journalistic sensationalism and no hope (guised as lack of critical thinking based on one poster's mistake on understanding peer review).  The facts are that there is $2.5 billion/year spent on drug development and research; and the scientific tools, methods, and basic understanding of today is light years ahead of where we were ten years ago (when HVTN 505 was initiated).

Also, to imply that HVTN 505 is "the ONLY vaccine trial in the works" just isn't true.    TAG's 2012 Pipeline report list approximately 25 phase I or II vaccine trials in the works, here is the link:

http://www.pipelinereport.org/browse/therapeutic-vaccines

I am a critical thinker, and based on the facts, I believe (and yes hope) that we will see some significant advancements in the next five years.

What really strikes me is how emotional the topic of a cure is -- which I understand logically (although respectfully acknowledge I can't have the same emotional understanding as those that have the history). Just as there has to be some room between "a cure within months" and "don't get your hopes up", there has to be some understanding and compassion for those that have been through (lived and died) the history and those that are new to this community and are going through this process at a different time in a different way.

I liked Mecch's statement that we need to have "two seemingly contradictory ways of thinking should be entertained simultaneously."

Best,
JM



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06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45%  VL 25
02/25/14 CD4   792/37%  VL UD
07/09/14 CD4 1004/39%   VL UD

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #41 on: May 09, 2013, 12:15:38 PM »
I watched the Trend The Prophet Dr David Owuor interview on youtube, especially the pertinent HIV Cure material starting at 5 mins.  Chilled me the bone.

It seems he's nationally important???? 

(Also every site includes slightly different details as to his exact credentials and diplomas from Israel and the US.)
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Dr.Strangelove

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Re: Two reported cured of HIV in Kenya?
« Reply #42 on: May 09, 2013, 03:04:44 PM »
What aggravates me is not youthful optimism and hope. It's the lack of critical thinking.

Critical thinking =/= pessimism.

What pisses me off is not the casual terminology of stating a cure is at hand it by overly optimistic newbies but by doctors and researchers who should know better.

Both the researchers in Denmark and this quack in Kenya should be ashamed of themselves and called out by the research community for how they have handled their press releases.

Completely agree with both statements.

I've been following the research forums here for almost 2 years now and often it makes me feel like 'Groundhog Day'. The same thing over and over again.

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #43 on: June 18, 2013, 04:07:32 AM »
How are you since last time. I am pleased to inform that my paper has been published at http://www.sciencepublishinggroup.com/journal/paperinfo.aspx?journalid=115&doi=10.11648/j.iji.20130102.11 I intent to publish the full methodology of the treatment soon so doctors and researchers all over the world can replicate it and improve it so that HIV is eliminated from the globe. I am not withholding or selling the methodology.


Offline Ann

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Re: Two reported cured of HIV in Kenya?
« Reply #44 on: June 18, 2013, 06:36:39 AM »
How are you since last time. I am pleased to inform that my paper has been published at http://www.sciencepublishinggroup.com/journal/paperinfo.aspx?journalid=115&doi=10.11648/j.iji.20130102.11 I intent to publish the full methodology of the treatment soon so doctors and researchers all over the world can replicate it and improve it so that HIV is eliminated from the globe. I am not withholding or selling the methodology.



Why aren't you publishing in a peer-review journal? If you want your research to be taken seriously, that's what you need to do. Anyone can publish on the website you did. Anyone.
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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

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HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #45 on: June 18, 2013, 11:57:44 AM »
Check properly. That is an online version of a peer reviewed journal and the article is on page 14-23 International Journal of Immunology with a proper DOI

Offline georgep77

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Re: Two reported cured of HIV in Kenya?
« Reply #46 on: June 18, 2013, 12:56:33 PM »
Dr. Barasa when are you expecting to publish the full methodology?
If you're not withholding or thinking about selling, what are you waiting for?

The medicine Nobel Prize is waiting if your findings are 100% effective.
« Last Edit: June 18, 2013, 12:59:19 PM by georgep77 »
Come on Sangamo,  Geovax,  Bionor immuno, ...Make us happy !!!
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Offline Dr.Strangelove

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Re: Two reported cured of HIV in Kenya?
« Reply #47 on: June 18, 2013, 04:33:20 PM »
Why aren't you publishing in a peer-review journal?

Ann, let me add the word reputable


When you google "science publishing group" this is the first hit (after their website):
"Science Publishing Group is another scam Open Access journal publisher or academic vanity press. "

Offline georgep77

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Re: Two reported cured of HIV in Kenya?
« Reply #48 on: June 18, 2013, 04:49:28 PM »
Check properly. That is an online version of a peer reviewed journal and the article is on page 14-23 International Journal of Immunology with a proper DOI

Science Publishing Group is notable for two things: spam and possible trademark abuse.

This publisher is currently unapologetically engaged in a massive spam campaign. They are spamming researchers all over the world soliciting manuscripts and editorial board applications. They may be harvesting email addresses themselves or they may be purchasing lists from companies that specialize in selling email addresses.

More info in this link:
http://scholarlyoa.com/2012/12/05/three-new-questionable-open-access-publishers/
Come on Sangamo,  Geovax,  Bionor immuno, ...Make us happy !!!
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Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #49 on: June 19, 2013, 04:58:54 AM »
Thanks for that information, I have checked it out. I will pursue the issue and see what to do.However this does not change my findings and results, only a transient headache

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #50 on: June 19, 2013, 05:05:33 AM »
I have not completely dismissed the journal yet but I am taking steps to verify these claims. Your info is from blogs and this is what one blogger says on the same site;

Martin William Bredenkamp

Thailand
March 22, 2013
I have been looking at the Science Publication Group as well since I also need papers printed. There are scammers out there who want to make a quick buck. The world is full of those.

I did, however, check this publication group and this is what I found: A new effort to create a chance to publish in a world where there is cut-throat competition. Electronic journals that are accessible to all at no cost. (Obviously they need to cover costs somewhere, so they charge the author only when his papers are accepted. Many journals do that.) They have been on the air since last year and there are papers accessible to all, and these papers do show up on Google.

What more do you want? Sure, they would be looking for reviewers and editorial board members – they have to start somewhere. 106 year ago, Martin Rundkvist, the acclaimed archeological journal was also a new upstart and could have had the same comments made about it. Maybe in a 100 years time this publication group will outstrip your acclaimed journal because they offer more general readability. Their impact factors will take a while to improve but if they have a found a niche, they surely will improve as people notice them and use them.

Scammers? No, I don’t believe so. What they need is good papers to put them in the market, and they will get them. Many of the acclaimed journals have puffed up editors and reviewers who will not allow the sun to shine on any of their competition, even if they are better and deserve a fair chance.

Science Publication Group! – Go for it.

Offline Ann

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Re: Two reported cured of HIV in Kenya?
« Reply #51 on: June 19, 2013, 05:43:13 AM »
Ann, let me add the word reputable


When you google "science publishing group" this is the first hit (after their website):
"Science Publishing Group is another scam Open Access journal publisher or academic vanity press. "

Absolutely. I had originally posted what I'll quote below, but I deleted it because I wanted to investigate further.

I appreciate that academics in developing nations may not have the money and/or resources to get published in reputable journals, so I decided to hang-fire until I could gather more evidence. I couldn't find any evidence that Science Publishing Group wasn't a scam, but I also couldn't find any direct evidence that it was a scam either. (if that makes sense?)

Quote

Check properly. That is an online version of a peer reviewed journal and the article is on page 14-23 International Journal of Immunology with a proper DOI

The International Journal of Immunology is not the sort of peer-review journal I'm talking about. I'm talking about a proper peer-review journal, like The Journal of Infectious Diseases for example, where your paper has to pass peer-scrutiny (peer-review) before it ever appears in the journal, much less online.


The SPG website has a list of people who allegedly review the articles, but all you have to do in order to qualify to review is to be published there yourself. Sounds like a circle-jerk to me.

Thanks for that information, I have checked it out. I will pursue the issue and see what to do.However this does not change my findings and results, only a transient headache

It gave me a headache too.

I have not completely dismissed the journal yet but I am taking steps to verify these claims. Your info is from blogs and this is what one blogger says on the same site;

Martin William Bredenkamp

Thailand
March 22, 2013
I have been looking at the Science Publication Group as well since I also need papers printed. There are scammers out there who want to make a quick buck. The world is full of those.

I did, however, check this publication group and this is what I found: A new effort to create a chance to publish in a world where there is cut-throat competition. Electronic journals that are accessible to all at no cost. (Obviously they need to cover costs somewhere, so they charge the author only when his papers are accepted. Many journals do that.) They have been on the air since last year and there are papers accessible to all, and these papers do show up on Google.

What more do you want? Sure, they would be looking for reviewers and editorial board members – they have to start somewhere. 106 year ago, Martin Rundkvist, the acclaimed archeological journal was also a new upstart and could have had the same comments made about it. Maybe in a 100 years time this publication group will outstrip your acclaimed journal because they offer more general readability. Their impact factors will take a while to improve but if they have a found a niche, they surely will improve as people notice them and use them.

Scammers? No, I don’t believe so. What they need is good papers to put them in the market, and they will get them. Many of the acclaimed journals have puffed up editors and reviewers who will not allow the sun to shine on any of their competition, even if they are better and deserve a fair chance.

Science Publication Group! – Go for it.


At the end of the day, Barasa, if you want to be taken seriously by the scientific community today (rather than in 100 years time), you're going to have to get published somewhere currently reputable.

I would suggest that maybe you contact an organisation like TAG to see how to go about getting your studies legitimised.
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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #52 on: June 19, 2013, 08:08:25 AM »
NO. At the end of the day, I do not want to be taken seriously. I want the work to be accessible by the scientific world so the next step can be taken. I checked again and I think it is new but authentic. I went through peer review myself and had to revise some parts according to the advice so what is claimed is hogwash.
Does the journal make my findings available to the scientific world? If so, then I go for it. Complications in communications can only lead to unnecessary delays as people die and suffer.
I discovered this methodology by unique opportunity, I believe, not anything special about me that nobody else has. What if something happens to me like death before this publication?
I am working on my next paper- the methodology used to achieve cure and guess what? I am going to publish it right there. If SPG is unknown, it will become very well known.

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #53 on: June 19, 2013, 08:33:40 AM »
I am Dr Simon Barasa Situma the originator of the HIV cure.

Since as you say, it's not a cure, but a step in the cure, why did you come up with this self-description...  Also why would you make a point of using the word "originator" if you aren't interested in recognition?  Every professor I know has career considerations and if someone is onto something, he/she may certainly be willing to share it around for the good of humanity, or some other good, but will NOT throw away personal benefit, in the process...

So lets get this straight.  The published work is about eliminating bone-marrow reservoirs.   But you already (?) have a complete "cure" technique, these methods and mysterious other "agents", and the world will hear about it in due time.... 

This complete cure has been accomplished by you? Or not yet?

If you have two complete cures, tell me now. PM me with names, etc.  My HIV doc is also a research professor in Geneva Switzerland of some renown. Also in with UN AIDS.  So, we can fly in the Kenyan cures and Dr. Barasa, get it all checked out to the satisfaction of our suspicious, perhaps culturally prejudiced minds. With the clout of UNAIDS and University of Geneva, this will all be done quickly for the benefit of humanity.  Because, Dr. Barasa, this will all be easily and quickly checkable, in the labs and conferences rooms of Geneva Switzerland.  You got the paper trails, I assume.  And its all on the up and up, so let's do this...   

We can raise money for the travel expenses on Kickstarter. 
« Last Edit: June 19, 2013, 08:48:19 AM by mecch »
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Ann

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Re: Two reported cured of HIV in Kenya?
« Reply #54 on: June 19, 2013, 08:43:14 AM »

NO. At the end of the day, I do not want to be taken seriously.


Fine. Just another quack then, eh?
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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline OneTampa

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Re: Two reported cured of HIV in Kenya?
« Reply #55 on: June 19, 2013, 10:35:08 AM »
Interesting thread through this eye of a needle HIV cure chat-a-bout.

"Show me the money!" is the catchphrase that comes to mind.

In this case, "Show me the undeniable, certifiable, absolutely reliable scientific evidence" of an HIV cure.
"He is my oldest child. The shy and retiring one over there with the Haitian headdress serving pescaíto frito."

Offline Dr.Strangelove

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Re: Two reported cured of HIV in Kenya?
« Reply #56 on: June 19, 2013, 10:57:00 AM »
Even though I feel these kind of (apparently empty) cure promises are disrespectful towards us pozzies, I must say that I feel rather amused by this episode. It's been one of the more interesting threads on here...

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #57 on: June 19, 2013, 12:00:34 PM »
I said I am publishing the full methodology without any alteration or reservation so from there it is up to everyone to take up and continue, so long as this publication is accessible. What use is publishing a proof of cure and withholding the methodology, even when you publish in SCIENCE?
I think I should take a break and concentrate on my publcation which I am working on now

Offline Jeff G

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Re: Two reported cured of HIV in Kenya?
« Reply #58 on: June 19, 2013, 12:24:08 PM »
Dr Basara ... You outright rejected Ann's suggestion to submit your finding to TAG ...
http://www.treatmentactiongroup.org/pipeline-report/2012

If you are sincere about your findings TAG is the place to take your work to be reviewed
This is the TAG mission statement


Treatment Action Group is an independent AIDS research and policy think tank fighting for better treatment, a vaccine, and a cure for AIDS.

TAG works to ensure that all people with HIV receive lifesaving treatment, care, and information.

We are science-based treatment activists working to expand and accelerate vital research and effective community engagement with research and policy institutions.

TAG catalyzes open collective action by all affected communities, scientists, and policy makers to end AIDS.

Im beginning to grudgingly believe that you think you have found something useful , if that is true and you really think you have something TAG is something you shouldn't ignore because if there is a shred of truth to your claims they wont ignore you .     

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #59 on: June 25, 2013, 04:36:17 AM »
Dr Basara ... You outright rejected Ann's suggestion to submit your finding to TAG ...
http://www.treatmentactiongroup.org/pipeline-report/2012

If you are sincere about your findings TAG is the place to take your work to be reviewed

I have checked and I don't think I need to. They are not publishers and they don't seem to have any clinical research agenda apart from activism.

I have submitted my paper to a reputable journal and is now in peer review. Lets wait.

Meanwhile I am so happy today, my two reported cured patients had another lab and the results are the same; undetectable , now it is 10 months since stoppage of HAART!

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #60 on: June 25, 2013, 04:37:20 AM »
I have checked and I don't think I need to. They are not publishers and they don't seem to have any clinical research agenda apart from activism.

I have submitted my paper to a reputable journal and is now in peer review. Lets wait.

Meanwhile I am so happy today, my two reported cured patients had another lab and the results are the same; undetectable , now it is 10 months since stoppage of HAART!

Offline buginme2

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Re: Two reported cured of HIV in Kenya?
« Reply #61 on: June 25, 2013, 12:38:40 PM »
This thread makes me want to pull my hair out

Offline Ann

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Re: Two reported cured of HIV in Kenya?
« Reply #62 on: June 25, 2013, 12:40:14 PM »
This thread makes me want to pull my hair out

There's a cure for that....
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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

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HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline geobee

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Re: Two reported cured of HIV in Kenya?
« Reply #63 on: June 25, 2013, 05:26:45 PM »
A current study of Methotrexate -- article is titled "Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs"

http://www.natap.org/2013/HIV/040213_01.htm

I also found a past clinical trial from 1999 that seems completed with no results posted
http://clinicaltrials.gov/ct2/show/study/NCT00000834

Sounds nasty --

Methotrexate is an approved anti-cancer drug which inhibits DNA synthesis. It is active against a wide range of tumours and is also used to treat severe psoriasis.

It has severe haematological, pulmonary, gastrointestinal and other toxicities. Common side-effects can include leukopenia (low levels of leukocytes, a type of white blood cell), thrombocytopenia (low levels of platelets), oral ulcers, diarrhoea, nausea and vomiting. It should not be taken by pregnant women.

Taking aspirin can reduce the amount of methotrexate that is excreted by the body, resulting in increased side-effects.

Methotrexate comes in the form of yellow tablets or a liquid for intravenous injection. It is available in a generic (non-brandname) formulation and is also manufactured by Pharmacia & Upjohn under the tradename Maxtrex

http://www.aidsmap.com/Methotrexate/page/1731362/

Offline buginme2

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Re: Two reported cured of HIV in Kenya?
« Reply #64 on: June 25, 2013, 05:45:38 PM »
A current study of Methotrexate -- article is titled "Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs"

http://www.natap.org/2013/HIV/040213_01.htm

I also found a past clinical trial from 1999 that seems completed with no results posted
http://clinicaltrials.gov/ct2/show/study/NCT00000834

Sounds nasty --

Methotrexate is an approved anti-cancer drug which inhibits DNA synthesis. It is active against a wide range of tumours and is also used to treat severe psoriasis.

It has severe haematological, pulmonary, gastrointestinal and other toxicities. Common side-effects can include leukopenia (low levels of leukocytes, a type of white blood cell), thrombocytopenia (low levels of platelets), oral ulcers, diarrhoea, nausea and vomiting. It should not be taken by pregnant women.

Taking aspirin can reduce the amount of methotrexate that is excreted by the body, resulting in increased side-effects.

Methotrexate comes in the form of yellow tablets or a liquid for intravenous injection. It is available in a generic (non-brandname) formulation and is also manufactured by Pharmacia & Upjohn under the tradename Maxtrex

http://www.aidsmap.com/Methotrexate/page/1731362/

What's your point? 

Yes there is research being done with methotrexate.  However, our dr barasa is doing his off the grid.  A search of clinicaltrials.gov shows zero trials that barasa is involved in.  Just because he says he has found a cure means absolutely nothing.

Linking actual research to this thread is pointless.

Offline geobee

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Re: Two reported cured of HIV in Kenya?
« Reply #65 on: June 25, 2013, 11:45:00 PM »
Well, I thought people might be interested in the drug, is all.  I thought it was interesting, thought other people might think so too. 

Like most of the people on this thread, I'll believe the Dr. when he's published his results in a reputable journal. 

Offline Jmarksto

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Re: Two reported cured of HIV in Kenya?
« Reply #66 on: June 26, 2013, 12:44:58 AM »
Geobee; thanks for the posts, it is interesting to have a little more background on the drug.

JM
03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45%  VL 25
02/25/14 CD4   792/37%  VL UD
07/09/14 CD4 1004/39%   VL UD

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #67 on: June 26, 2013, 03:37:21 AM »
From my experiments, methotraxate doesn't seem to have those side effects especially in HIV because it is absorbed immediately on ingestion by the "HUngry" bone marrow and as soon as we begin to see its blood effects, we stop as we know that then the bone marrow is saturated. However it remains very dangerous to use because of other effects which I have explained in the paper and how to overcome these.
Methotraxate  has been used in clinical trials before, but not with the benefit of the scientific principles at http://www.dovepress.com/true-story-about-hiv-theory-of-viral-sequestration-and-reserve-infecti-peer-reviewed-article-HIV, or how to eradicate the secondary HIV reservoir elsewhere in the body.

It is all in the paper.
« Last Edit: June 26, 2013, 03:58:28 AM by barasa »

Offline georgep77

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Re: Two reported cured of HIV in Kenya?
« Reply #68 on: June 27, 2013, 07:26:57 PM »
If it's true that Dr.Barasa it's not holding or selling the wannabe cure
I'll give him the benefit of the doubt.

PS: I take every research involving the word "cure" with a grain of salt.
Lately the media is mentioning the word cure for stuff not even in Phase I...   ???
Come on Sangamo,  Geovax,  Bionor immuno, ...Make us happy !!!
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Offline Jmarksto

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Re: Two reported cured of HIV in Kenya?
« Reply #69 on: June 27, 2013, 08:35:25 PM »
I'll give him the benefit of the doubt.

While I have no F'ing clue if Dr. Basra is onto a cure, I do know:

1.) The only two people cured so far  (Tim Brown and the Mississippi baby) have been cured by clinicians that have used existing treatments in unique ways -- not by large trials.

2.) We have to admit that there is a cultural bias -- it is much easier to get a doctor  in Mississippi to connect to the established medical community than a doctor in Kenya.

For those two reasons alone I am willing to give the benefit of the doubt.

JM

Modified to correct the spelling of Mississippi...
03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45%  VL 25
02/25/14 CD4   792/37%  VL UD
07/09/14 CD4 1004/39%   VL UD

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #70 on: June 28, 2013, 04:21:50 AM »
If it's true that Dr.Barasa it's not holding or selling the wannabe cure
I'll give him the benefit of the doubt.

PS: I take every research involving the word "cure" with a grain of salt.
Lately the media is mentioning the word cure for stuff not even in Phase I...   ???

The reason is cure is not useful if it is not used where it is needed. What is the use of curing just a few people when millions are affected? Timothy brown is cured but this means nothing to the rest if his cure cannot be replicated in them. Of course my cure is derived from his case, so it means a lot after all.

Is it possible to enrich myself from this cure by withholding and selling? Yes, but at what expense? A lot of lives lost, suffering, economic loss, and finally even with billions in my accounts, I remain just me. I cannot eat or use more than a normal human being.

Besides I have a lot more to do and keeping glued to HIV will be an impediment to me, that is why I need others to pick up and finish the job of eradicating HIV from the globe. Even if I was given 100000... lifetimes I could never possibly do that on my own.

Here is what you should wait for:

Manuscript:   Methodology used in Experimental Cure of HIV in Two HAART experienced Patients in Nairobi, Kenya
Journal:   HIV/AIDS - Research and Palliative Care
Status:    2a - Peer Review invitations sent
Sub ID:   50354
Submit Date:   23/Jun/2013
View Comments | View uploaded files

 
« Last Edit: June 28, 2013, 04:40:03 AM by barasa »

Offline Ann

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Re: Two reported cured of HIV in Kenya?
« Reply #71 on: June 28, 2013, 06:35:20 AM »

I have submitted my paper to a reputable journal and is now in peer review. Lets wait.


Which journal, and how's it going? (I'm genuinely interested.)
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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #72 on: June 28, 2013, 06:49:04 AM »
And please take down that YouTube video, it's just too weird.  ;D
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #73 on: June 28, 2013, 07:05:24 AM »
I have pasted the details on my previous post.

I hope you understand that it is not easy to get published, especially in the older journals. They have a huge backlog of accepted yet to be published work and are seriously constrained. Add to the fact that a paper is not coming from a recognized top notch research team in a premier institute with a list of co-authors and a well funded research base with state of the art laboratory and technical equipment.

And there are those peer reviewers who won't tolerate anything apart from accepted positions. My paper is about elucidation of new theories on HIV and I have gone through rough roasting by reviewers. But thank God, I have still managed to get published. I hope this goes well too.


Offline Pek

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Re: Two reported cured of HIV in Kenya?
« Reply #74 on: June 28, 2013, 11:16:23 PM »
   I know the word cure means a lot. But i see many people in this forum hopeless about the cure what I think it could happen in months or decades. But I have hope.
   Most of us are not doctors and Dr Barasa is one and he is working towards the cure so we should  be thankfully to him regardless of what is his goal on that(save the humankind from HIV or money(what I dont think so) or whatever).
   I dont know nothing about medical research but I ve read some other research about new medicines or way to treat HIV and from what I remember they had some phase 1, 2 and 3 trial. But I dont know if all this is needed if he is just suggesting an available medicine to treat a different disease.
   If I am not wrong the first medicine available and kind of successful to beat HIV was AZT which was a medicine to treat cancer and was already available on the market. The same as methotraxate the one mentioned by Dr Barasa.
   I think if Dr Barasa is working on his own or kind of(what I dont know) then I think could be a good idea to some big organization that works towards the cure could try to go to Kenya and check all this at least.
   From what I understood in Dr Barasa treatment is that it works attacking the HIV on the reservoirs and make your body free of virus forever. I am not sure but I think I read about some test to check the amount of HIV on reservoirs but even if they are really expensive why dont check on those 2 patients. I dont think it could be so expensive thinking in 30 million people that could be free of this disease.
   Dr Barasa, regardless of your results on this trial I am very thankfully to you for the work towards the cure.
« Last Edit: June 28, 2013, 11:18:42 PM by Pek »

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #75 on: June 29, 2013, 06:14:29 AM »
A cure is  a cure, it is straight forward and has no phases. When you hear of phase 1, 2 or 3 trials for any drug, it means its effectiveness is already established and what is sought is data on the safety in a larger proportion of people with different characteristics in order to determine its suitability, especially when alternative treatments are available.

Good thing, methotraxate has been used from 1947 and there is great volumes of data on it already so we don't need clinical trials of that nature. All we need is validation of the methodology and fine tuning here and there, but it should start to be applied immediately. Of cause scientists will continue studies even when the methodology is in use, as happens with all other drugs in use.

When I say cure I mean we have removed both the bone marrow reserve and all viable reserves from the rest of the body. I have already proved this for my two patients, and others yet to be published. I have about 35 patients on treatment so far.

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #76 on: June 29, 2013, 08:36:10 AM »
When I say cure I mean we have removed both the bone marrow reserve and all viable reserves from the rest of the body.

I have already proved this for my two patients, and others yet to be published.

I have about 35 patients on treatment so far.

3 bold statements.
« Last Edit: June 29, 2013, 08:38:51 AM by mecch »
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline leatherman

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Re: Two reported cured of HIV in Kenya?
« Reply #77 on: June 29, 2013, 10:45:46 AM »
But i see many people in this forum hopeless about the cure what I think it could happen in months or decades. But I have hope.
I think you have woefully misunderstood many people here then  :(
And misunderstood the science of how drugs/cures are created;
and not learned the 30+ year history of the HIV epidemic.

I doubt anyone here is HOPELESS about a cure. They (and I) are just very realistic about a cure. For a bunch of us who have lived with HIV for three decades already, we're been hearing the claims that the cure is "just around the corner" or "coming in months" for a long time. Not for months; but for decades, those kinds of claims have been circulating.

In the last 3 decades, science has made incredible leaps-n-bounds in learning so much about HIV, a retrovirus; but just like science hasn't cured the cold, measles, or flu, it hasn't been able to cure this even tricker virus. When you understand how science, peer review, and trials work, you will know that there is no cure that will be here in MONTHS. Perhaps a few years at best; but nothing in the pipeline is anywhere near arriving in months. That's because there's nothing out there yet that has gone through and stood up in the trials, proving itself a "cure" yet. It takes a very long time for human trials to determine the side effects and effectiveness of any medication.

And that process of research, validation, and trials is why barasa is receiving so much critique and skeptisism here. Lofty claims of cures - "cures" that haven't gone through proper research, validation, peer review and trails - have been with us since the beginning of the HIV epidemic. I personally know of people, my friends, who died following some of claims. Others I know have suffered through terrible "extra" side effects following unproven, undocumented drugs and treatments. So far all of those claimed cures have been shams and scams. So far the only medications that have been PROVEN to have any negative effect on HIV have been the numerous ARVs that have come to market.

I've lived with HIV for 30 years, and AIDS 20 of that. I'm not "hopeless"; but I have" high hopes" that a cure might just be found in my lifetime. However, I don't live any of my life waiting, anticipating, or even dreaming of the day when a cure arrives. I take my ARVs every day, and try to live every day to the fullest - because those ARVs have given me that potential. I follow the science, not only working towards a cure; but of the work to improve the meds that are available. If barasa has truly worked on and discovered the method for clearing HIV, for a "cure", then science in the form of proper research, peer review, validation and trials will prove that. Until that day though, his claims (and I did read through his very long presentation ;) ) here without that proof might just be a lot of smoke-n-mirrors. I for one will not be placing any of my "hope" at this time in such fragile, unsubstaniated claims. I wish barasa good luck in his work and HOPE to see, if this really is the "cure", his work validated and put through proper peer review and trials in the upcoming years.
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline Trout

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Re: Two reported cured of HIV in Kenya?
« Reply #78 on: June 30, 2013, 04:19:06 AM »
This article says "he [Dr. Basara] has achieved this using a method that comprises the use of a cancer drug (methotraxate) in combination with other agents. Other agents?

Now please tell me that the secret ingredient isn't PEARL OMEGA.

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #79 on: June 30, 2013, 04:41:06 AM »
There are those with average intelligence, others somehow with less of it. I said I am publishing the full methodology, now where is this pearl omega thing coming in?

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #80 on: June 30, 2013, 07:20:00 AM »
There are those with average intelligence, others somehow with less of it. I said I am publishing the full methodology, now where is this pearl omega thing coming in?
What are you implying?  Critical thinking and skepticism are not the same thing and furthermore, neither is bad.

Are you saying hard questions and skepticism by HIV+ people about cures and in particular, yours, is a sign of weak intelligence?

At the moment, you are inspiring me to remember a half dozen Yiddish words....

“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #81 on: June 30, 2013, 07:34:40 AM »
Now Relax. That doesn't seem like a hard question to me. Have a look at http://www.ncbi.nlm.nih.gov/pubmed/23733447

I didn't take down the video though, sorry. Don't remember how to. You don't have to watch it; just read the text which I believe is put in such a way that even a non-medic can understand.

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #82 on: June 30, 2013, 11:28:28 PM »
What does this article have to do with your work? I don't see your name.
http://www.ncbi.nlm.nih.gov/pubmed/23733447
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline leatherman

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Re: Two reported cured of HIV in Kenya?
« Reply #83 on: July 01, 2013, 01:29:19 AM »
There are those with average intelligence, others somehow with less of it.
Mecch, maybe he thinks the skeptics here have HIV-Associated Neurocognitive Disorders, and that's why we don't just automatically believe he's found the cure.  :D LOL

Quote
HIV cure can be described as failure of peripheral viral
load resurgence and peripheral viral clearance on stoppage
of highly active antiretroviral therapy (HAART) in a
treatment experienced individual with remarkable viral load
control.1, 2  In these individuals, viral load is expected to
begin rising within days following stoppage of HAART.1,
Wasn't there a report out recently that discussed how SOME people who had been on ARVs were able to stop their medications and not have a resurgence in viral load? without taking methotraxate?

ah ha! found it. http://www.aidsmap.com/French-researchers-report-14-patients-in-remission-after-controlling-HIV-for-over-4-years-off-treatment/page/2602347/
Quote
Two weeks ago, the announcement that a baby had been ‘functionally cured’ of HIV disease with the use of very early antiretroviral therapy (ART) caused great excitement at the start of the Conference on Retroviruses and Opportunistic Infections (CROI 2013). Now a study from France has found 14 adult patients who also started a course of ART soon after infection, who subsequently stopped it, and have not had to re-start because they have largely – and in eight cases completely – maintained undetectable viral loads for at least four years after stopping therapy (the baby has, so far, only managed a year off therapy).

Furthermore, the researchers suggest that such cases are only not more common simply because, once having started ART, few people stop. They estimate that 15% of people with HIV, if ART is started within six months of HIV infection and maintained for at least a year, could subsequently become so-called “post-treatment controllers”.

Their estimate is a stark contrast to findings from studies conducted between 1996 and 2000, soon after the introduction of highly active antiretroviral therapy, which found no evidence that people who began treatment in primary infection could control HIV after stopping treatment. The key difference between those studies, and the French patients described this week, is that earlier studies looked at HIV control in people who had only received treatment for 12 to 18 months. The French patients had been on treatment for an average of three years before stopping, and all started treatment within ten weeks of infection, compared to within six months in previous studies.
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #84 on: July 01, 2013, 03:12:43 AM »
Good, leatherman, I can see you can be a good researcher. The explanation is very simple, and I have put it clearly in the paper. If you get HAART before the virus is hidden into the bone marrow i.e before sero-conversion, you will be cured as HIV cannot become chronic without bone marrow reserve. It is the bone marrow reserve that  helps build the latent reservoir which then becomes a problem to eradicate.

The same principle is used in post-exposure prophylaxis, Postprep, where if you suspect you have exposure you start HAART without waiting for a positive test, and it works!

For the baby and the French men, obviuously they did not get the virus into the bone marrow. After all they are the same humans like u and me, the only difference is the timing.

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #85 on: July 01, 2013, 09:03:35 AM »
This thread makes me want to pull my hair out

It is exactly interesting to know that most of latent HIV is actually in the skin, mostly the scalp and the groin area where infected T memory cells are kept in a sort of quarantine like death row inmates. The immune system does this because it has no capacity to eliminate all of them at once so it buys time to build this capacity. When you develop the capacity by immuno-reconstitution, the immune system starts to attack this latent reserve, but unfortunately runs out of supplies before finishing the job. meanwhile the 'liberated'[ latently infected cells become activated and proceed to viral production so that more latent reserve is formed.

So, yes it is entirely possible to feel like pulling your hair out, may be not entirely because of the thread.

What I do is remove the incessant supply from the bone marrow and add the capacity of the immune system to clear latent reserve in one round.

Clear enough?

Offline Jmarksto

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Re: Two reported cured of HIV in Kenya?
« Reply #86 on: July 01, 2013, 10:15:48 AM »

What I do is remove the incessant supply from the bone marrow and add the capacity of the immune system to clear latent reserve in one round.

Clear enough?

Dr. Basara,

Please excuse my lack of understanding, but it isn't clear for me. My understanding is that the Methotrexate liberates the virus from the bone marrow, however what is used to add additional capacity to the immune system to clear the latent reserve?  Also, what is the duration of treatment for each step?

Thanks,
JM
03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45%  VL 25
02/25/14 CD4   792/37%  VL UD
07/09/14 CD4 1004/39%   VL UD

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #87 on: July 01, 2013, 12:30:08 PM »
Methotraxate clears infection from the bone marrow by denying the virus access to vulnerable fast multiplying cells on which it depends. The immune system is like an army at war and it operates on  financial system for its logistics.

If the system is corrupted as it is in HIV, it fails, and I have identified what is needed to be done to give it the edge over the virus.

For duration, it depends on each individual i.e the size of the reservoir and the level of accumulated waste, anything between 3 weeks and six months. But methotraxate is only taken in two days.

Offline Jmarksto

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Re: Two reported cured of HIV in Kenya?
« Reply #88 on: July 01, 2013, 02:09:47 PM »
If the system is corrupted as it is in HIV, it fails, and I have identified what is needed to be done to give it the edge over the virus.

When you say "the system" I assume you mean the immune system.  I couldn't find a description of what is used to give the immune system the edge in your paper, other than this statement:

"Since the blood picture obtained for these patients did not show any
deficiencies, only mineral and vitamin supplements were given to maintain the immune system activity.
"

Is there treatment beyond what is described in your paper?

Also, I don't recall seeing an explanation as to when HAART was stopped - I'm assuming after the Methotraxate treatments.

Thank you for your patience,

JM
03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45%  VL 25
02/25/14 CD4   792/37%  VL UD
07/09/14 CD4 1004/39%   VL UD

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #89 on: July 01, 2013, 05:46:55 PM »
Sometimes the way you explain HIV progression seems to be based on UNTREATED cases.

Still, I get the point about what you are doing for the bone marrow.

Your hypothesis about strengthening the immune system seem neither to be based on people on HAART with long controlled HIV replication, nor always a clinical goal for them.  Many of us do not need immune boosting; we need to remove reservoirs.

Wish you would clarify "other agents" mentioned in your own texts and news items about your work.
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #90 on: July 02, 2013, 04:38:28 AM »
    HIV reservoirs are due to competition between the virus and the immune system where the virus has the upper hand. So HAART is very important to slow down viral processes and you cannot be cured if you have not controlled your viremia with appropriate HAART.

    Due to long standing duel between the virus and the immune system, and due to resultant accumulation of waste and backlog of unfinished immune operations, all immune systems of HIV sufferers is below bar. A few people may have very strong systems, especially those recently diagnosed or those who started HAART earlier and are fully compliant. These are likely to clear the virus pronto, but are not the majority.

    Some members may feel I am trying to force the treatment down their throats while they are happy the way they live with HAART, let me say this;

[I only joined the forum because of a software that alerts me whenever there is a discussion in my name, not to shop for patients
I have done enough experiments and I have proved the point importantly to myself. After publication those who wish to prove the point to themselves will be at liberty. For that reason I am not taking in more patients
This cure is not meant for you in particular, it is for all of us , it is for the world, both the infected and uninfected.
In fact it is the uninfected who need it most because it is an assurance that they will not be infected in future. HIV infection is a geometric progression in the population and surely after some time, everyone is going to have it, if there was no cure and HAART becomes resistant or the virus mutates
look at the figures;
1981- a few homosexuals and iv drug users
1986-several thousands
1990-several millions
2000-30 million
2050?
2100= almost everyone]

Offline RicardoBrazil2

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Re: Two reported cured of HIV in Kenya?
« Reply #91 on: July 03, 2013, 12:56:09 PM »
    I've been followed this thread for a while and today i saw this report on BBC News
http://www.bbc.co.uk/news/health-23132561
which seems to corroborate with Dr. Barasa's theory, although the researches warned that is too soon to declare a cure. A new bone marrow without the CCR5 DELTA 32 mutation (which was used in Berlin patient) was  used this time and even so this 2 patients appear to be HIV free for weeks up to now. I guess this could give Dr Basara's theory an ideal scenery at the international medical comunity to be presented officially.

Offline Tadeys

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Re: Two reported cured of HIV in Kenya?
« Reply #92 on: July 03, 2013, 04:29:16 PM »
@ Rocardobrazil2: somewhat. But remember that with these 2 bone-marrow transplants---without the delta-32 mutation--scientist think that host-vs-graft helped eliminate HIV reservoirs & latent HIV. Some therapeutic vaccines are trying to do this in a way..i.e., by training the immune system to seek HIV. Bionar's Vax-4 is one of these vaccines. There are plenty in the pipeline.

Many Steps & many strategies are going to be needed at fist to get rid of HIV from the body. Perhaps in 20-25 years we will have a single pill or a single injection that will cure HIV...Basara's metrotrexate(spelling?) can be ONE of the many steps & therapies needed to get rid of HIV.

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #93 on: July 18, 2013, 04:02:11 AM »
I have published the full methodology of HIV cure at https://www.researchgate.net/publication/249656879_Methodology_used_in_Cure_of_HIV_by_Stopping_Reverse_Dissemination_from_CD4_T-_Lymphocyte_Progenitors_in_Two_HAART_experienced_Patients_in_Nairobi_Kenya. This is  a non-peer reviewed publication and I am still working to publish in a peer reviewed journal, but this may take some time.Some reviewers just do not agree with my principles which are substantially different from accepted positions ( that is why it works) , while others recommend a very technically thorough write up, which as for me is tough as I have done this research experimentally just on my own and I do not have some of the technical data.
 
This publication should enable other scientists to investigate.

You may forward this link to scientists  across the globe and let them prove or disprove my claims.

These are some of reviewers comments I am getting;

Quote
Review #1 -
In my opinion the paper is not well written, shows little understanding of the literature or pathogenesis.  There is no logical or scientific thinking and it has no clear methods or data.  I do not recommend this manuscript for publication.

Obviously it is them who do not understand anything, just relying on books and books for what they purport to know.

Quote
Review #2 -
The reported clearance of HIV would constitute breaking news in the field. Methotrexate has been used for treatment of lymphomas and other conditions for a relatively long time and is considered safe at the used doses. Therefore, the quality of the report need to be substantially improved to attract the attention it deserves. To being with, the layout of the draft does not comply with the accepted publishing practice: Summary, Introduction, Methods, Results, Discussion and References. The sections Aims, Hypotheses and Justification are not used in scientific reports and should be removed. Methodology should include the technique applied to measure HIV viremia, cell counts and details of treatment. The fact that the 2 responding patients have been negative for HIV viremia for 9 months after methotrexate treatment and HAART suspension needs to be included in the Abstract. Results should be organized in a table indicating the number of patients included, the number of responders
  to methotrexate, age, gender, time in HAART before treatment, CD4 counts, CD4 nadirs if available, presence of cancers, TB and other health conditions. Responses in 2 out of 16 patients means a success rate of 12.5%, and the title and general writing should clearly reflect this fact. The 4th paragraph in page 8 could be presented as a graph for each patient, even if the full data set is available for only some of them. An important consideration is the possibility of residual HIV replication to levels below the detection limit of the used assay.

This is not a case report, the report is already published! This is simply a methodology used to attain the results so the blah blah should not apply!

Unfortunately there is no opportunity to answer reviewers so let us take it slow. Eventually it will be published.
 

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #94 on: July 18, 2013, 06:01:44 AM »
You've got a chip on your shoulder, or a lot of chutzpah.  People take your work seriously (and isn't that the objective) and yet GENEROUSLY give their time and expertise to explain how your message and your work might be better disseminated. 

And you have several times belittled such information / advice and the people giving it to you, as beside the point, useless, "blah blah", unintelligent, and so on...

Everybody could win, but you almost seem to sabotage your effort so it ends up lose lose, not win win.

Also there is a DEEP evasive streak in almost all your communication....



“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #95 on: July 18, 2013, 06:29:58 AM »
It is not easy for everybody to understand this, even the peer reviewers who are mostly professors of virology find it difficult. I have talked to leading scientists one on one but they all seem to have a lot of trouble getting the point. However, medical novices and laymen are better able to grasp and follow my ideas.

It is because academicians have been taught in the same way of thinking and it is difficult to change the way they think. Laymen have more open minds.

I should like to meet you some day, especially after my methodology has been universally proved and accepted, and you have used it to get back your dignity.

Offline Ann

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Re: Two reported cured of HIV in Kenya?
« Reply #96 on: July 18, 2013, 06:38:42 AM »

I should like to meet you some day, especially after my methodology has been universally proved and accepted, and you have used it to get back your dignity.

Whoa, are you saying that a cure will give us back our dignity? How arrogant!

I've been poz for years and I have NOT lost my dignity, thank you very much!

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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Habersham

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Re: Two reported cured of HIV in Kenya?
« Reply #97 on: July 18, 2013, 06:44:01 AM »
If Dr Barasa was a legitimate research scientist who had found a cure for AIDS, would he have the time to participate in this forum to this extent?

NO!

Just his bothering to spend so much time posting here discredits him. I'm glad I never clicked on this link before.
Because I Can

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #98 on: July 18, 2013, 06:52:27 AM »
You are a pharmacist, and some sort of scientist.  You need to start acting like a responsible practitioner of your chosen profession, and stop belittling all the people who are also telling you to act professionally...

The reviewers number 2's comments on your research were very constructive... Why not take them and grow in your profession... 

We all share the same goal. If achieving the goal means you have to "play the game" a little bit, you know just strategically, well dearie, that's the way it works in all jobs...

People have bent over backwards to take your intent seriously but you need to step up your communication game...
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #99 on: July 18, 2013, 07:34:10 AM »
Quote
Whoa, are you saying that a cure will give us back our dignity? How arrogant!

I've been poz for years and I have NOT lost my dignity, thank you very much

Oh yes, not just you, but if anyone of us has a disease such as HIV then we all lose our dignity. Imagine what will happen in a hundred years if everyone is infected and there is significant antiretroviral treatment failure. People will never be able to lead normal lives, with increased death rate and most of all, inability to reproduce normally. That is what I call losing dignity!

So it is not arrogance but it is the truth, like it or not.

Quote
If Dr Barasa was a legitimate research scientist who had found a cure for AIDS, would he have the time to participate in this forum to this extent?

NO

I have a lot of time to live normally. I have never been to a research lab; I only analyse  and interpret what other scientists have already done and I have immensely acknowledged their works in my own works. I could never have achieved this without their publications.

So expect me around in POZ, as long as it exists.

Quote
We all share the same goal. If achieving the goal means you have to "play the game" a little bit, you know just strategically, well dearie, that's the way it works in all jobs..

Yes dearie, I agree completely, but consider;
  • I may not have the capacity to carry out all those things they want as an individual
    I must report an important finding like this so those with capacity can investigate further
    Call a spade a spade ; if some learned fellow cannot tell the difference between a report and a methodology....no kind words especially if his folly can cause delays in this important publication
    Delay is used by HIV to conquer body defenses, by killing the very first CD4s that profile it hence a delay in seroconversion as it establishes reservoirs.

Offline mecch

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Re: Two reported cured of HIV in Kenya?
« Reply #100 on: July 18, 2013, 07:53:25 AM »
If you can't engage with and respect experts in your field, in my opinion you have no right "treating" HIV+ people.  You are painting yourself as a Dr. Frankenstein... Sure you want that? 

Also, you throw too many tangential statements into your defence...
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline barasa

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Re: Two reported cured of HIV in Kenya?
« Reply #101 on: July 18, 2013, 08:08:52 AM »
I don't need to defend myself over anything. HIV cure is just the tip of the iceberg, I have got a lot more. Just stay alive and you will see for yourself. The future is now here. I can't give hints now as that may arouse loud debates and obliterate the current topic before it is concluded.

Once this is through, I will start the others.

Offline Ann

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Re: Two reported cured of HIV in Kenya?
« Reply #102 on: July 18, 2013, 08:22:37 AM »

I have a lot of time to live normally. I have never been to a research lab; I only analyse  and interpret what other scientists have already done and I have immensely acknowledged their works in my own works. I could never have achieved this without their publications.

So expect me around in POZ, as long as it exists.


Well, that's where you're wrong. You've only been permitted to post here as a courtesy, due to your alleged scientific background. The only sections of these forums normally open to hiv negative individuals are the Someone I Care About, Am I Infected? and Off Topic, a section that is for non-hiv related subjects only.

Your arrogance and wilful ignorance of scientific protocol are beyond the pale. You are henceforth banned from posting in these forums.

Good luck in your endeavours - I hope you at some point come to your senses and realise that scientific protocol is in place for a reason, and start following it.

Ann
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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline wolfter

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Re: Two reported cured of HIV in Kenya?
« Reply #103 on: July 18, 2013, 08:33:49 AM »


Your arrogance and wilful ignorance of scientific protocol are beyond the pale. You are henceforth banned from posting in these forums.


Thanks for giving many of us our dignity back. ;D  Something I hadn't even realize was missing.
productivity breeds content

Offline buginme2

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Re: Two reported cured of HIV in Kenya?
« Reply #104 on: July 18, 2013, 12:28:50 PM »
This thread should be locked.

There are many people who come to the forums looking for hope.  It's one thing to start a discussion about some kokamamy cure from Kenya.  It's another thing to have the actual "researcher" post how he has found a cure before it  has had a chance to be properly vetted. 

Going on a forum for people who are affected with a certain disease and saying you have a cure for that disease (without going though the proper scientific steps) in my opinion is shady and immoral. 

I've seen it posted many many times how the forum takes the science regarding HIV very seriously and works hard to make sure the data presented to its members is valid.  This Dr Barsa doesn't meet those standards.

Offline Dr.Strangelove

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Re: Two reported cured of HIV in Kenya?
« Reply #105 on: July 18, 2013, 02:16:07 PM »
I'm generally all for open discussion and against locking threads.
But in this case, yes, please let's lock it and move on...

Offline Ann

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Re: Two reported cured of HIV in Kenya?
« Reply #106 on: July 18, 2013, 02:23:39 PM »
I'm not going to lock it. If I do, sooner or later someone will probably start a new thread about it. We still can't be sure whether or not he may be on to something, and neither will he until he wises up and starts practicing proper protocol and shows a little more respect to the wider scientific community.

If there's a lack of interest in his ideas, the thread will slowly drop out of sight. If people keep posting only to make comments about Barasa or calling for the thread to be locked, it will only keep it hovering near the top.
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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline leatherman

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Re: Two reported cured of HIV in Kenya?
« Reply #107 on: July 18, 2013, 06:33:44 PM »
It's one thing to start a discussion about some kokamamy cure from Kenya.  It's another thing to have the actual "researcher" post how he has found a cure before it  has had a chance to be properly vetted.
I know I'm keeping this going, but....  :P

cure? I read his stuff. Basically, he quotes the life cycle and functions of HIV based upon other people's work. Then he follows with more research from others about how HIV "hides" in reservoirs, and those reservoirs needs to be flushed if the HIV is ever going to be completely cleared/cured/medicated out of someone. After nearly thirty years of paying attention to the science and studying this issue/disease that killed so many friends and partners (and nearly myself!), personally, I didn't see anything new that I didn't already know about the science of HIV.

of course, he (barasa) claims he's found the trick/medication that will tease out the reservoirs; but without clinical data and trials to back up those claims, it all just sounds like more pie-in-the-sky this-will-be-the-cure-in-another-10-years sort of nonsense we hear over and over and over. It's definitely no real "cure". At best, it's just the thought/whisper behind a cure sometime in the far future.
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline Trout

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Re: Two reported cured of HIV in Kenya?
« Reply #108 on: August 31, 2013, 09:56:16 AM »

Offline Tadeys

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Re: Two reported cured of HIV in Kenya?
« Reply #109 on: August 31, 2013, 03:46:14 PM »

 Daily Nation. Great scientific journal. Read it all the time... ::)

Offline freewillie99

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Re: Two reported cured of HIV in Kenya?
« Reply #110 on: August 31, 2013, 09:49:37 PM »
This thread is like the undead.  Please let it go, zombie nation.
Beware Romanians bearing strange gifts

 


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