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Author Topic: UK paper reporting Scientists on brink of HIV Cure-  (Read 10964 times)

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Offline Dr.Strangelove

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  • Posts: 206
Re: UK paper reporting Scientists on brink of HIV Cure-
« Reply #50 on: May 09, 2013, 03:07:53 PM »
That is a good point though. We HIV people don't have a monopoly on sloppy reporting...

Offline atlanta05

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  • Posts: 18
Re: UK paper reporting Scientists on brink of HIV Cure-
« Reply #51 on: May 09, 2013, 04:11:19 PM »
I'm optimistic. Cycnicism isn't going to help me or my life.

Offline Miss Philicia

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  • celebrity poster, faker & poser
Re: UK paper reporting Scientists on brink of HIV Cure-
« Reply #52 on: May 09, 2013, 04:51:30 PM »
There really is nothing quite like the Club for Junior Scientists on internet forums.
"I’ve slept with enough men to know that I’m not gay"

Offline freaky_dream

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  • Posts: 132
  • mmm
Re: UK paper reporting Scientists on brink of HIV Cure-
« Reply #53 on: May 09, 2013, 11:07:19 PM »
What do you expect from a media that doesn't know the difference between HIV and AIDS. Every headline that comes out on HIV research almost always uses AIDS rather then the corrrect HIV.

Offline jkinatl2

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  • Doo. Dah. Dipp-ity.
Re: UK paper reporting Scientists on brink of HIV Cure-
« Reply #54 on: May 15, 2013, 01:14:01 PM »
There really is nothing quite like the Club for Junior Scientists on internet forums.

Please to read the disclaimer on the POZ news page:

http://www.aidsmeds.com/articles/misleading_reports_1667_23916.shtml

I have great optimism for the future. I also think that a newly diagnosed person who breathlessly lurches from news article to news article looking for t "cure" instead of coming to terms with the illness s/he is likely to live with for a decade or more (perhaps a lifetime) is only postponing the process by which s/he will be able to handle the difficulties that surround the diagnosis and treatment of HIV.

That's not optimism, it's delusion.

Skepticism isn't cynicism.

"Many people, especially in the gay community, turn to oral sex as a safer alternative in the age of AIDS. And with HIV rates rising, people need to remember that oral sex is safer sex. It's a reasonable alternative."

-Kimberly Page-Shafer, PhD, MPH

Welcome Thread

Online mecch

  • Member
  • Posts: 11,251
  • red pill? or blue pill?
Re: UK paper reporting Scientists on brink of HIV Cure-
« Reply #55 on: May 15, 2013, 02:45:05 PM »
Please to read the disclaimer on the POZ news page:

http://www.aidsmeds.com/articles/misleading_reports_1667_23916.shtml

I have great optimism for the future. I also think that a newly diagnosed person who breathlessly lurches from news article to news article looking for t "cure" instead of coming to terms with the illness s/he is likely to live with for a decade or more (perhaps a lifetime) is only postponing the process by which s/he will be able to handle the difficulties that surround the diagnosis and treatment of HIV.

That's not optimism, it's delusion.

Skepticism isn't cynicism.

I agree.
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline geobee

  • Member
  • Posts: 266
Re: UK paper reporting Scientists on brink of HIV Cure-
« Reply #56 on: May 22, 2013, 01:42:02 PM »
Here's a good analysis of the story and actual state of the science/research. Well written, too. 

By Richard Jefferys, Project Coordinator at Treatment Action Group (TAG)

http://tagbasicscienceproject.typepad.com/tags_basic_science_vaccin/2013/04/reviewing-strategies-for-draining-hiv-reservoirs.html

Offline Dr.Strangelove

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  • Posts: 206
Re: UK paper reporting Scientists on brink of HIV Cure-
« Reply #57 on: May 22, 2013, 07:03:02 PM »
Yes, great article.

Offline Matts

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  • Posts: 205
Re: UK paper reporting Scientists on brink of HIV Cure-
« Reply #58 on: July 02, 2013, 10:41:46 AM »
There were some preliminary results in Kuala Lumpur. It seems that they were able to wake up a decent amount of latent cells. But it is still too early to say something definitive.

"Hidden HIV virus can be forced out of hiding

Danish researchers have taken a small step towards a cure against HIV.

Preliminary results from a clinical study by HIV researchers from Aarhus University Hospital in Denmark confirm the hypothesis that a new drug can reactivate latent HIV in humans. The results were presented today to other international researchers at the 'HIV Cure Symposium' in Kuala Lumpur in Malaysia.

When HIV penetrates the body, it integrates into the DNA of certain immune cells and enters a resting state. In this resting state, cells carrying HIV in their genome are unrecognisable to the immune system. Antiretroviral medicine effectively suppresses virus production and thus, HIV disease progression, but currently there is no treatment that can remove the latent HIV hidden in these cells.

A group of researchers from Aarhus University Hospital and Aarhus University has used a drug called panobinostat (LBH589) - a so-called HDAC inhibitor - which was previously shown to activate hidden HIV virus in laboratory tests. In theory this means that it will be easier for the immune system to trace and fight the cells hiding the virus.

Now researchers have taken a further step. During treatment of 15 Danish HIV-infected patients with panobinostat (LBH589), an increase in HIV in the blood has been measured. This means that the researchers have successfully forced the immune cells carrying HIV out of their resting state, which is a prerequisite for allowing the immune system to identify and eliminate these cells. None of the patients have experienced serious side effects. Yet, the researchers urge to interpret the results with caution.

- It has never previously been seen that HDAC inhibitors can force hidden virus out of otherwise inactive immune cells to an extent where this can be measured in the blood in persons infected with HIV. Therefore, these are groundbreaking results. However, it is important to stress that we are not close to a cure against HIV, but we have taken a small step further towards a cure. The next challenge is whether the patients' immune system can identify the cells with virus and kill them, says Head of Research Martin Tolstrup, Aarhus University and Aarhus University Hospital.

Facts
• The study is made in collaboration with specialists in Melbourne, Boston, Sydney and Colorado; the study is conducted at Aarhus University and Aarhus University Hospital in Denmark.
• Globally, 33 million people are infected with HIV.
• The first significant results involving 15 HIV patients at Aarhus University Hospital show that HIV virus can be activated by panobinostat (LBH589), a so-called HDAC inhibitor, originally developed for cancer treatment.
• The Danish Council for Strategic Research – the Individuals. Disease and Society programme – has supported the project with DKK 12 million. The American organisation amfAR – the Foundation for AIDS Research – and the Danish AIDS Fondet have also supported the study. "

http://www.en.auh.dk/news+and+media/news+archive/shownews?showNews=128307

and the same in the Yellow Press :)

http://scandasia.com/danish-breakthrough-in-the-fight-against-hiv-revealed-in-malaysia/
tivicay/kivexa

Offline Cosmicdancer

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  • Posts: 146
Re: UK paper reporting Scientists on brink of HIV Cure-
« Reply #59 on: July 02, 2013, 01:55:18 PM »
- "It has never previously been seen that HDAC inhibitors can force hidden virus out of otherwise inactive immune cells to an extent where this can be measured in the blood in persons infected with HIV. Therefore, these are groundbreaking results. However, it is important to stress that we are not close to a cure against HIV, but we have taken a small step further towards a cure. The next challenge is whether the patients' immune system can identify the cells with virus and kill them, says Head of Research Martin Tolstrup, Aarhus University and Aarhus University Hospital."

It's not clear why they're saying the next challenge is whether the patient's immune system can identify the cells with virus and kill them.  I thought it's understood that the immune system is not very effective at killing HIV and that we need to rely on ARVs to do that.  Aren't the 15 people in this trial on ARVs which are keeping them undetectable?  Does this mean they are seeing blips in their viral load?  The reporting is really unclear.  Hopefully some better written articles will be coming out. 

Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
June, 2008 - undetectable, 612 cd4
January, 2009 - undetectable, 670 cd4
May, 2009 - undetectable, 593 cd4
Sept, 2009 - 83 vl, 763 cd4, 34%
Dec, 2009 - undetectable, 889 cd4, 32%
April, 2010 - undetectable, 860 cd4, 31%
October, 2010 - undetectable, 800 cd4, 38%
April, 2011 - undetectable, t-cell test not done
October, 2011 - undetectable
April, 2012 - undetectable, 850 cd4, 39%
November, 2012 - undetectable, 901 cd4, 41%
April, 2013 - undetectable, 846 cd4, 36%
October, 2013 - undetectable
May, 2014 - undetectable, 784 cd4, 48%

Offline Matts

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  • Posts: 205
Re: UK paper reporting Scientists on brink of HIV Cure-
« Reply #60 on: July 02, 2013, 02:32:42 PM »
I think clinicaltrials.gov answers these questions:
http://clinicaltrials.gov/ct2/show/NCT01680094

If I understand it correctly the transcription in the latently infected cells is measured through unspliced HIV-RNA and  the chances in the latent pool through proviral HIV-DNA per 10⁶ CD4+ T-cells or so..

The ART free period should start now,I think that we will know in 3 months if it was a success or another failure.

"Primary Outcome Measures:

    Change from baseline in HIV transcription in latently infected CD4+ T-cells as measured by copies of unspliced HIV-RNA in the CD4+ T-cells of HIV-infected patients on suppressive HAART [ Time Frame: Day 1 (before study drug and 2 hours after first dose), Day 2, 5, 10, 15, 24, 29, 38, 43, 52 ] [ Designated as safety issue: No ]


Secondary Outcome Measures:

    Change from baseline in the size of the latent HIV-reservoir as measured by copies of proviral HIV-DNA per 10⁶ CD4+ T-cells [ Time Frame: 12 and 32 weeks after initiation of study treatment ] [ Designated as safety issue: No ]
    Change from baseline in the frequency of cells latently infected with replication competent HIV expressed as infectious units per million (IUPM) [ Time Frame: 12 weeks after initiation of study treatment ] [ Designated as safety issue: No ]
   
    Plasma HIV-RNA as measured by the single copy assay [ Time Frame: Day 1 (before study drug and 2 hours after first dose), Day 2, 5, 10, 15, 24, 29, 38, 43, 52, 84, 224 ] [ Designated as safety issue: No ]
    During an optional HAART-interruption study (if performed, see below): 1) Time to viremia >1000 copies/ml; 2) Time to meet criteria to restart HAART [ Time Frame: To be performed upon completion of 32 weeks follow-up based on the below specified criteria ] [ Designated as safety issue: No ]

    Upon completion of the study, subjects may be invited to participate in an additional observational study in which HAART will be interrupted to evaluate the effect of study treatment on virological control. Enrolment into this study is optional and conditioned by the following criteria pertaining to the effect of study treatment on the latent HIV-1 reservoir:
        Significant increase in unspliced HIV-RNA during in accordance with the primary endpoint measure
        Profound reduction in reservoir size indicated by >75% decrease in total HIV-DNA/106 CD4+ T-cells or total HIV-DNA below the limit of detection
(defined as 5 copies/106 CD4+ T-cells) at week 36
        CD4+ T-cell count >500/mm3
« Last Edit: July 02, 2013, 02:54:32 PM by Matts »
tivicay/kivexa

Offline RobbyR

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  • Posts: 314
Re: UK paper reporting Scientists on brink of HIV Cure-
« Reply #61 on: July 03, 2013, 11:38:37 AM »
Hopefully if there is something to this, they can find a way to trick the body and clear the HIV from the blood without having to have a bone marrow transplant, obviously everyone with HIV can't do something that extreme, but maybe it is the start of promising research into drugs that don't merely keep the virus at bay, but actually CURE it once and for all! I do think we have reason to hope more now than in many years past!
Started Atripla August, 2010.

 


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