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Author Topic: For all complera peeps  (Read 1381 times)

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Offline gadawg1979

  • Member
  • Posts: 142
For all complera peeps
« on: April 01, 2013, 02:26:20 AM »
Will start this off. Post as u see fit. First question, do the hot flashes ever stop?
Diagnosed March 2012
Initial CD4- 156 VL 200K (started Complera) Genotype test no resistance
First labs on meds CD4- 246 VL 2K Taken after 30 days on Complera
90 Day labs VL 306 No CD4 Drawn
8/21/2012 CD4 474 VL Undetectable (40) %20.6
11/27/2012 CD 4 522 VL Undetectable (40)
2/14/2013 CD 4 464 VL Undetecable (30) 19.6%
6/8/3013 CD 4 528 VL Undetectable (30)
9/24/2013 CD 4 546 VL Undetectable (40)
1/30/2014 CD4 560 VL Undetectable (40) 22 %
6/19/2014 CD4 584 Vl Undetecable (30)

Offline Matts

  • Member
  • Posts: 209
Re: For all complera peeps
« Reply #1 on: April 03, 2013, 11:30:24 AM »
Dietary requirements changed in Europe for fixed dose combination rilpivirine/tenofovir/FTC (Eviplera) (Complera)

Summary:390kcal, 12g Fat are enough (not 540kcal, 21g Fat as before)

"On 20 March 2013, Gilead isseud a letter noting that the European Medicines Agency (EMA) had modified the Summary of Product Characteristics (SPC) for the fixed dose combination rilpivirine/tenofovir/FTC (Eviplera). [1]

The new recommendation is to take Eviplera “with food”. Previously the indication was “take with a meal” (See Section 4.2 in the SPC). [2]

This was based on a review of results from a pharmacokinetic study that was presented at the Glasgow conference, reporting a slightly different impact of food on rilpivirine absorption when part of the fixed dose combination Eviplera compared to when taken as a separate medication. [3]

This study reported that rilpivirine and tenofovir exposure are increased after intake of a standard (533 kcal, 21 g fat) or light meal (390 kcal, 12 g fat) relative to fasting conditions. Compared to fasting conditions, rilpivirine AUC was 9% and 16% higher with a light meal or standard meal, respectively. Compared to standard meal, RPV AUC was 14% and 6% lower with fasted or light meal administration, respectively. These details have not been added to Section 5.2 of the SPC on pharmacokinetic proterties.

These changes only relate to the prescribing information with regard to food intake for the FDC formulation. The SPC for single agent rilpivirine still retains the requirement to take with a standard (533 kcal) meal."

http://i-base.info/htb/21240
http://www.jiasociety.org/index.php/jias/article/view/18333/1776
tivicay/kivexa

Offline Ann

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  • Member
  • Posts: 28,140
  • It just is, OK?
    • Num is sum qui mentiar tibi?
Re: For all complera peeps
« Reply #2 on: April 04, 2013, 03:53:16 AM »

First question, do the hot flashes ever stop?

I'm guessing that nobody responded to your question because no one else (here anyway) has been having hot flashes that they're attributing to Complera.

Have you talked to your doctor about this? One thing that comes to mind is hormone levels - have yours been checked? Thyroid possibly too. Have your thyroid levels been checked?

Please talk to your doctor about this.
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Offline gadawg1979

  • Member
  • Posts: 142
Re: For all complera peeps
« Reply #3 on: April 07, 2013, 10:39:19 PM »
Thanks Anne will do know I have border line low t
Diagnosed March 2012
Initial CD4- 156 VL 200K (started Complera) Genotype test no resistance
First labs on meds CD4- 246 VL 2K Taken after 30 days on Complera
90 Day labs VL 306 No CD4 Drawn
8/21/2012 CD4 474 VL Undetectable (40) %20.6
11/27/2012 CD 4 522 VL Undetectable (40)
2/14/2013 CD 4 464 VL Undetecable (30) 19.6%
6/8/3013 CD 4 528 VL Undetectable (30)
9/24/2013 CD 4 546 VL Undetectable (40)
1/30/2014 CD4 560 VL Undetectable (40) 22 %
6/19/2014 CD4 584 Vl Undetecable (30)

Offline Torchwood

  • Member
  • Posts: 48
Re: For all complera peeps
« Reply #4 on: May 12, 2013, 10:07:52 PM »
No. They do not. I still have them on occasion. The side effects do wear mostly off. Check my thread that I am about to update that chronicles my treatment with Complera.
Discovered 4/2006
VL: 1600
CD4: 1005
Started Complera 10/2011
VL: 48,500
CD4: 570
1/17/12
VL: Undetectable
CD4: 890
4/12
VL: Undetectable
CD4: 895
11/12
VL: Undetectable
CD4: 1193
4/12
VL: Undetectable
CD4: 1461
11/13
CD4: 1273
VL: Undetectable
5/14
CD4: 1788
VL: Undetectable

 


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