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CROI 2013

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Thanks JM: but still don't know where yellowfever got his info since CROI has not  started... ???

I know this gene therapy CAN work, but it all depende on how much editing can be done on the cells( in terms of porcentaje of over all cells without the gene) ...the more, the better.

 My bet is on callimune (RNAi). But still have my fingers crossed for Sangamo.


Yellow got the title of the presentation from the CROI program (see the link in the opening post of this thread), although I believe the comments in quotes are really Yellow's him/herself's.



 I saw the title; just can not seem to find the following:

"Not every patient's CD4 cells went up after our therapy but we think we know why"

"And don't ask us about Viral Load"

Perhaps he made it up, but since it is quoted seems that he read it somewhere. somehow I think this is old info Sangamo released...


Some fascinating and promising basic research and some disturbing presentations:

374 HIV Preferentially Infects Hematopoietic Progenitor Cells with High CD4 and Can Be Found in CD133+ Hematopoietic Progenitor Cells in a Subset of Optimally Treated People with Long-term Viral Suppression

Lucy McNamara*, N Sebastian, A Onafuwa-Nuga, J Riddell, D Bixby, and K Collins
Univ of Michigan, Ann Arbor, US

This means that in some individuals the virus is not only in our bone marrows but in (I presume) unipotent "stem"cells, I if I were to guess within the lymphoid lineage which inclueds our T-Cells, both CD4 and CD8, B-cells and natural killer cells. However CD4 is also expressed on monocytes and macrophages too, and there is not enough information in the title to say which hematopoietic population the indentified cells belong to.

Bottom line is, as these progenitors grow up and divide any integrated virus goes along with them-another damn reservoir.

The CD133+:

CD133, originally known as AC133.[1] CD133 is a glycoprotein also known in humans and rodents as Prominin 1 (PROM1).[2] Currently the function of CD133 is unknown. It is a member of pentaspan transmembrane glycoproteins (5-transmembrane, 5-TM), which specifically localize to cellular protrusions.

CD133 is expressed in hematopoietic stem cells,[3] endothelial progenitor cells,[4] glioblastoma, neuronal and glial stem cells,[5] various pediatric brain tumors,[6] as well as adult kidney, mammary glands, trachea, salivary glands, placenta, digestive tract, testes, and some other cell types.[7][8]

Yeah Mishma, saw that this morning... :o  Stopped reading the CROI pdf after I saw this.

So, What's the good news?

 I think gen therapy is the only solution (for now)...hopefully the CD8 cells that are being "trained" to hunt down HIV infected cells also kill off these stem cells.

And Regarding stem cells: did'nt some research show last year that stem cells where NOT infected with hiv?  Remember reading it.


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