Quantcast

Subscribe to:
POZ magazine
Newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr Instagram
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
March 28, 2015, 09:28:46 PM

Login with username, password and session length


Members
Stats
  • Total Posts: 659732
  • Total Topics: 50589
  • Online Today: 227
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Reduced Dose Sustiva Effective With Less Side Effects...  (Read 1128 times)

0 Members and 1 Guest are viewing this topic.

Offline OneTampa

  • Member
  • Posts: 2,382
  • "Butterflies are free."
Reduced Dose Sustiva Effective With Less Side Effects...
« on: January 14, 2015, 08:54:41 PM »



As I have noted here on the boards a number of times, I have been on reduced Sustiva now for over 15 years and remained undetectable.

Links to December 2014 Report of Study:

http://i-base.info/htb/27640

http://www.hivandhepatitis.com/hiv-treatment/approved-hiv-drugs/4985-hiv-drug-therapy-lower-dose-efavirenz-may-be-equally-effective-with-fewer-side-effects
« Last Edit: January 14, 2015, 08:57:26 PM by OneTampa »
"He is my oldest child. The shy and retiring one over there with the Haitian headdress serving pescaíto frito."

Offline zach

  • Member
  • Posts: 2,239
Re: Reduced Dose Sustiva Effective With Less Side Effects...
« Reply #1 on: January 14, 2015, 10:42:34 PM »
Hey Tampa, I've got some interest in this.

Mind if I ask you a few questions?

Were you ever on the full dose? What made you reduce the dosage? The dosage that is in Atripla is 600 mg, how does that compare with your dosage.

Thanks
An honest tune with a lingering lead has taken me this far

Offline bmancanfly

  • Member
  • Posts: 622
  • Medicare For All !
Re: Reduced Dose Sustiva Effective With Less Side Effects...
« Reply #2 on: January 15, 2015, 08:57:29 AM »
Interesting article comparing 600mg dose vs 400 mg dose.  This quote from the article was really caught my eye;

"Almost 80% of participants reported EFV related adverse events at baseline and about 80% of these reported improvement after switching to the lower dose".
"The trouble with the world is that the stupid are cocksure and the intelligent are full of doubt."

 Bertrand Russell

Offline OneTampa

  • Member
  • Posts: 2,382
  • "Butterflies are free."
Re: Reduced Dose Sustiva Effective With Less Side Effects...
« Reply #3 on: January 15, 2015, 07:07:33 PM »
Hey Tampa, I've got some interest in this.

Mind if I ask you a few questions?

Were you ever on the full dose? What made you reduce the dosage? The dosage that is in Atripla is 600 mg, how does that compare with your dosage.

Thanks

I was on the full 600 mg dose for about 1 month.

I reduced the dose because of the horrid side effects.  I felt drunk and lost my balance. I was going to go off the medication altogether but my Specialist said that he read about a small study that noted a reduced dose of 400 mg was just as effective as 600 mg.  I tried it and the awful side effects disappeared nearly immediately.

I never had bad dreams, depression or diminished cognitive function.
"He is my oldest child. The shy and retiring one over there with the Haitian headdress serving pescaíto frito."

Offline zach

  • Member
  • Posts: 2,239
Re: Reduced Dose Sustiva Effective With Less Side Effects...
« Reply #4 on: January 15, 2015, 07:44:28 PM »
So obviously this has been known about for years... fuck me
An honest tune with a lingering lead has taken me this far

Offline Jeff G

  • Member
  • Posts: 14,429
  • How am I doing Beren ?
Re: Reduced Dose Sustiva Effective With Less Side Effects...
« Reply #5 on: January 15, 2015, 08:06:12 PM »
So obviously this has been known about for years... fuck me


It just makes me think I may have only kinda wanted to kill myself and I would have been
1/3 less insane on the reduced drug … good riddance to Atripla .

Offline zach

  • Member
  • Posts: 2,239
Re: Reduced Dose Sustiva Effective With Less Side Effects...
« Reply #6 on: January 15, 2015, 08:13:35 PM »
yeah, i'm sitting here remembering my state of mind on sustiva... pisses me off more than a lot to hear the doctor should have known what was going on and offered up solutions

after a suicide attempt he patted me on the hand, said we don't want that to happen again, tossed me more atripla and sent me on my way
An honest tune with a lingering lead has taken me this far

Offline MitchMiller

  • Member
  • Posts: 490
Re: Reduced Dose Sustiva Effective With Less Side Effects...
« Reply #7 on: January 16, 2015, 12:25:52 AM »
I think this is the study conducted by the World Health Organization in 2013.  There was a thread on it here.  After I saw that report, I've been alternating between 400 mg and 600 mg dose.  With this analysis, I guess I can safely switch entirely to 400 mg and save some $$$.

What's strange though is that two of the 200 mg capsules seem to cause insomnia more frequently than the 600 mg tablet... but the effects the next day are definitely reduced.  I was still undetectable after several months of this regimen.

I noted this comment at the bottom of the article in the first link:

Results from ENCORE1 were first announced in July 2013. Subsequent discussions since have identified the need to confirm that the 400 mg dose will be robust in the presence of TB treatment and in the third trimester of pregnancy.
« Last Edit: January 16, 2015, 12:31:26 AM by MitchMiller »

Offline BKKKevin

  • Member
  • Posts: 60
Re: Reduced Dose Sustiva Effective With Less Side Effects...
« Reply #8 on: January 16, 2015, 07:21:00 AM »
Mitch... When you say alternating do you mean 400 on day and 600 the next day and then back to 400 or prolonged usagage of 400 for several days then back to 600 for several days?... I could see where varing dosage one day to the next could cause insomnia as your body does not have time to adjust to dosage...

Offline MitchMiller

  • Member
  • Posts: 490
Re: Reduced Dose Sustiva Effective With Less Side Effects...
« Reply #9 on: January 18, 2015, 04:04:08 PM »
What I meant was literally alternating day by day. 

I also noted that in the Asian trial they were breaking the 600 mg tablets in half.  I'm using the two of the 200mg capsules for my 400 mg dose.

Offline Botahtaung

  • New Member
  • Posts: 1
Re: Reduced Dose Sustiva Effective With Less Side Effects...
« Reply #10 on: January 24, 2015, 01:31:55 AM »
If you take any therapy with Efavirenz you should ask your doc to measure levels of EFZ in your blood. Several people around me where desperatly depressed and suicidal: taking 600 mg resuled in levels 10 fold more than needed. Switching to 300mg resulted in still too high level but a total change in side effects: depression disappeared. If you can change your regime away from Sustiva: go for it. Dont experiment - have your levels measured by a professional.

Offline MitchMiller

  • Member
  • Posts: 490
Re: Reduced Dose Sustiva Effective With Less Side Effects...
« Reply #11 on: March 25, 2015, 10:08:16 PM »
I've now switched to a 5 and 2 regimen, where I take 400mg EFV five days per week and two 600mg EFV two days per week.  I put two or three days between each 600mg dose so I never do the two back-to-back. 

What I'm noticing now is that I really can feel the higher dose (600mg) vs the lower dose.  In about six months I should exhaust my 600mg supply of pills and be on only the 400mg dose going forward.

I'm beginning to think the higher dose has been acting as a sedative all these years and that's why the lower dose seems to be causing insomnia.  Perhaps it's my body just weaning itself off the sedative effects of the higher EFV dose.

 


Terms of Membership for these forums
 

© 2015 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.