Quantcast

Subscribe to:
POZ magazine
Newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr Instagram
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
October 24, 2014, 01:07:24 PM

Login with username, password and session length


Members
Stats
  • Total Posts: 643415
  • Total Topics: 48956
  • Online Today: 195
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Survival Gene May Be Key to Controlling HIV and Hepatitis  (Read 1218 times)

0 Members and 1 Guest are viewing this topic.

Offline tednlou2

  • Member
  • Posts: 4,986
Survival Gene May Be Key to Controlling HIV and Hepatitis
« on: November 29, 2012, 11:24:32 PM »
From U.S. Centers for Disease Control and Prevention

November 26, 2012

Dr. Marc Pellegrini and Dr. Greg Ebert of the Infection and Immunity Division of the Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, and colleagues from the University of Toronto conducted research that discovered a gene called Arih2 that is important to the function of the immune system. The gene is essential for embryo survival and could be key to treating chronic infections such as HIV, hepatitis, and TB.

Dr. Pellegrini described Arih2, which is found in dendritic cells, as the sentinels of the immune system that play an essential role in the body's response to the presence of foreign invaders. He stated that Arih2 is responsible for the decision that the immune system makes as to whether the immune response should be initiated and progressed or whether it should be switched off to avoid development of chronic inflammation or autoimmunity. He explained that the immune system works well against many infections, but some organisms have developed ways of exhausting the immune system so that the system switches off. He listed HIV, hepatitis B, and TB as examples of organisms that counter the immune response -- exhausting T cells "which are stimulated over and over again by the infection" and then become exhausted or paralyzed. He said that with this discovery, researchers should be able to reinvigorate the immune response temporarily to boost the immune system and help clear these infections.

Dr. Ebert stated that the research team was examining the effect on the immune response of switching off Arih2 for short periods of time during chronic infections and looking at how manipulating Arih2 and associated pathways promote immunity in chronic infections. He noted that Arih2 showed promise as a drug target. The researchers state that it would take many years for the discovery to be translated into a drug that can be used by humans, but that the discovery has significant implications for manipulating the immune response to infections and suppressing chronic inflammation or autoimmunity, as researchers can target this agent to try to push immune responses in different directions, either promoting or suppressing it.

http://www.thebodypro.com/content/69824/survival-gene-may-be-key-to-controlling-hiv-and-he.html

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.