Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
July 29, 2014, 01:30:06 PM

Login with username, password and session length


Members
Stats
  • Total Posts: 632262
  • Total Topics: 47877
  • Online Today: 259
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Atripla & Drug interaction  (Read 8979 times)

0 Members and 1 Guest are viewing this topic.

Offline Delby

  • Member
  • Posts: 108
Atripla & Drug interaction
« on: April 10, 2008, 06:30:41 AM »
Hi All,

Well i'm coming up to the 9 week mark on meds now. My 1st set of results after intiating treatment (4 week mark) showed my CD4% increase from 19 - 29%, CD4 didnt really change from 319 - 340, and VL went from 71,000 to 275 copies. I'm a little disappointed my CD4 didnt increase much, but i know I must be patient and thankful that at least the meds are reducing the amount of virus!!

My question is with regards to a particular drug interaction with Atirpla (i'm on Truvada & Sustiva). My doctor is not easy to get a hold of, and despite texting and emailing him, he has not responded to me. So I was wondering whether anyone could help advise me. I am suffering from severe insomnia and i'm lucky if I get 4hrs sleep a night. Most nights I dont sleep at all and its causing me to feel extremely fatigued all the time. I have been trying to contact my doctor to ask him whether Seroquel (Quetiapine) is safe to use with Truvada & Susitva, but like i said, he never gets back to me. It can be used as a sleeping aid and pre-meds i found it worked quite well in helping me sleep.

Does anyone know if Seroquel is ok to use with my combination as i dont want to risk causing any interactions?

Thanks to all!

D :)

PS What i'd do for a good nights sleep!!! Insomnia is horrible!!!

Offline J.R.E.

  • Member
  • Posts: 7,099
  • Joined Dec-2003 Living positive, since 1985.
Re: Atripla & Drug interaction
« Reply #1 on: April 10, 2008, 08:07:18 AM »
Hello,

See if this drug interaction chart may help you out.

http://www.hiv-druginteractions.org/frames.asp?drug/drg_main.asp


If not,try calling the pharmacy , where you purchase your meds. Let them know what your concerns are, they should be able to give you some answers.

EDITED :  See if this link can help you out also. There is a drug interaction tab on the link below :

http://www.drugs.com/atripla.html


Take care----Ray
« Last Edit: April 10, 2008, 08:15:40 AM by J.R.E. »
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 12.5mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


 In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started my first  HAART regimen  on October 24th,03.

 As of 6/4/14,  t-cells are at 423, Viral load <40

 Current % is at 13% 

  
 62 years young.

Offline penguin

  • Member
  • Posts: 747
  • The Penguin Whisperer
Re: Atripla & Drug interaction
« Reply #2 on: April 10, 2008, 09:05:05 AM »
J, glad new meds are doign their stuff

sustiva may be causing/ contributing to insomnia - do discuss this with yr dr if it's continuing

the seroquel, sustiva can decrease plasma levels of this..so people takign this every day for its original use as an antipsychotic may need their seroquel dose adjusted. But for your purposes, no, shouldn't be an issue. However, it would be a good idea to keep trying to get hold of your hiv consultant to run this by him - or whoever prescribed it initially (GP?) - just so he's aware that this is an ongoing issue.

pharmacy team at the hospital can always give you info on interactions etc, as ray says.

i send you some tcell-growing thoughts  :) kate

Offline bimazek

  • Member
  • Posts: 781
Re: Atripla & Drug interaction
« Reply #3 on: April 17, 2008, 07:06:28 PM »
herbal valerian which is in every drug store in california and all vitamin sections
i take 2, 3 or even 4 and sleep like a baby
with none of the terible side effects from all those "BETTER"
pharmacudical sleep meds

try herbal valerian

it is what they use to make valium out of
it relaxs and you have refresed sleep


Offline MYSTERY

  • Member
  • Posts: 186
Re: Atripla & Drug interaction/Valarian Root
« Reply #4 on: June 23, 2008, 10:06:32 PM »
I have been using Valerian Root to help with sleep. When I called my pharmacy they said the Valarian Herb could have a moderate drug interaction with Atripla. Has any one else using Valarian heard this. It has been working for sleep better than Ambien CR and would like to continue using it. Any info would be appreciated.
Atheist don't believe in GOD, but GOD believes in them and loves them. Never let the failure of man conflict with your love of GOD.

Offline MYSTERY

  • Member
  • Posts: 186
Re: Atripla & Drug interaction
« Reply #5 on: June 23, 2008, 10:16:13 PM »
First, you should definitely discuss your concern for overuse of Ambien with your doctor. You should also discuss your interest in herbal alternatives.

While it is unclear whether or not many of the herbal supplements interact with medications, it has become a matter of gambling to mix the two.

Valerian was associated with some liver damage, but this was attributed to contamination (which is a risk for many supplement products). Cytotoxic abilities of valerian have been demonstated in a test tube situation, but not yet in people. Why this is remains unknown. One research group suggested that the real effects of valerian were so mild that "engaging in soothing activities such as taking a bath or listening to relaxing music" may be as effective. Adequate safety studies have not been done, particularly in the arena of drug interactions.

Milk Thistle (contains silymarin) has held some promise for reducing liver toxicity, but there have been some limitations with oral supplementation due to the poor solubility and absorption of this product. While it has been suggested that the active substance can be injected to overcome these issues, it adds concern about puncturing the skin. Interactions with anti-HIV medications are also unclear.

What to do? Great question... and much depends on your feeling about the potential benefit versus the gamble of interactions. I don't think that there is an answer clear enough to make a responsible recommendation to you at this time. If you do decide to take one or both of these herbal drugs, it is worthwhile to let your doctor and pharmacist know so that they can keep track of you, your lab values, and any new information that may come up that will support the use of these herbs or suggest discontinuation due to safety issues.
Atheist don't believe in GOD, but GOD believes in them and loves them. Never let the failure of man conflict with your love of GOD.

Offline sharkdiver

  • Member
  • Posts: 1,350
Re: Atripla & Drug interaction
« Reply #6 on: June 23, 2008, 10:50:43 PM »
Hey MYSTERY

Welcome to the forum.  You had some very good advice about checking with your doc and pharmacist over possible interactions and side affects of herbal supplements.


So... what's your story? how about an introduction (Living With Maybe?)?

Welcome again,

Sharkie

Offline MYSTERY

  • Member
  • Posts: 186
Re: Atripla & Drug interaction
« Reply #7 on: June 23, 2008, 11:33:41 PM »
Hey Sharkie,

Thanks for welcoming me to the forum.  I have been on Atripla for 3 1/2 years and have been doing great with it except for some sleep issues. I have tried Ambien CR and find that it leaves me feeling forgetful and hung over. I tried the Valarian Root and it seemed to put me at ease and I feel asleep while using it. Then after I spoke to my pharmacist, she felt that there may be some interaction that may cause some issues with liver function. So if I continue to have sleep issues, I might just start taking the Atripla in the a.m.   
Atheist don't believe in GOD, but GOD believes in them and loves them. Never let the failure of man conflict with your love of GOD.

Offline BreakerOneNine

  • Member
  • Posts: 65
    • Myspace
Re: Atripla & Drug interaction
« Reply #8 on: June 24, 2008, 10:41:42 AM »
Like I have stated in all the other Atripla threads......Once I started taking Atripla in the AM.....My sleep was so much better.
poz 96 and med free til now.
Sept 2007 cd4 280 28.37% and VL 19,200
Nov 2007 cd4 230 25.87% and VL 38,000
Dec 2007 start Atripla
Jan 2008 cd4 490 32.5% and VL 119
Feb 2008 cd4 450 28.4% and VL less than 50
April 2008 cd4 510 28.6% and VL less than 48
July 2008 cd4 570 30.2% and VL less than 48
Dec 2008 cd4 570 32.0% and VL less than 48

BobF

  • Guest
Re: Atripla & Drug interaction
« Reply #9 on: June 24, 2008, 12:58:06 PM »
My Doc, thank goodness, is terrific in terms of responding to phone calls, emails, or messages left with a nurse.  He even has called to check up on me when I've been ill (as I am now).   I think he's one of the best Doc's I've ever had.   If yours doesn't respond to you, I'd start looking for someone with better patient relations!

Bob

Offline OutOfDarkness

  • Member
  • Posts: 90
Re: Atripla & Drug interaction
« Reply #10 on: June 26, 2008, 07:14:08 PM »
My Doc, thank goodness, is terrific in terms of responding to phone calls, emails, or messages left with a nurse.  He even has called to check up on me when I've been ill (as I am now).   I think he's one of the best Doc's I've ever had.   If yours doesn't respond to you, I'd start looking for someone with better patient relations!

Bob

Hey Bob, hope your feeling better soon.   :)

Mystery,

Hi and welcome!  I think it would be important to check with the doc and let them know what you want to take as far as herbal supplements, even if you are not taking hiv meds it would be important to run it by a physician.  But I recall reading that some herbal supplements can cause negative side effects/toxicities in people taking hiv meds.  Anytime I have to make any change in medications I always let my doctor know, even if I have to go to a specialist to have like some type of testing done and I have to take a preparation for the procedures, I always check back to my hiv doc and make sure that what I am taking is ok.  Not only is it important for mixing the wrong medications, but it is also important to do in case you do come down with something gastrointestinal so that your doctor knows what he may or may not have to test for. 

Good Luck and hope your sleep gets better!
2000 - seroconverted
2005 - cd4 350, VL 113,000
3/06 - started sustiva/truvada
3/08 - cd4 1,300 VL >50(undet.)

Offline MYSTERY

  • Member
  • Posts: 186
Re: Atripla & Drug interaction
« Reply #11 on: June 26, 2008, 09:53:28 PM »
Thanks for the info I have stopped taking the herbal supplement. I took it for just a couple of nights. However, I have been sleeping well again and have not been taking any sleeping med (Ambien CR). I hate that stuff. If I have any problems in the future that are consistant, I think I am going to take the Atripla around 11 am just before I work out. My new "bucky" eye mask seems to help me sleep better at night along with ear plugs. I guess whatever works right.
Atheist don't believe in GOD, but GOD believes in them and loves them. Never let the failure of man conflict with your love of GOD.

Offline colby

  • member
  • Posts: 2
Re: Atripla & Drug interaction
« Reply #12 on: June 26, 2008, 11:05:43 PM »
Hi D,

I am new to the forum and I just posted a similar experience (insomnia) that I had with Isentress.  I truly do feel for you as I felt like a prisoner of fatigued, eternal wakefulness. 

Please persist with trying to reach your doctor as the Sustiva can definitely bring some people to the edge as I discovered (I did not experience insomnia with Atripla, in fact I wanted to sleep all the time, dreams got bizarre, fatigue and depression out of hand).  If you are feeling depressed at all, treat it as an emergency. 

Good luck and please let us know when and how you resolve.

Colby

Offline Delby

  • Member
  • Posts: 108
Re: Atripla & Drug interaction
« Reply #13 on: July 02, 2008, 11:15:09 AM »
Just a quick update to those following this thread. After suffering with no solution to my insomnia for quite some time I decided that, having tried every sleeping aid on the market (both herbal and prescribed) that I would consult a sleep clinic. I had my 1st consultation about 1 month ago. The doctor prescribed 1 x 7.5mg of Mirtazipine and 1 x 3mg of Melatonin. Having tried everything from Seroquel to Zopiclone, none of which worked, i was rather skeptical to say the least about this new regime. However, it has worked. Allbeit I am getting 5+ more hrs of sleep a night which for the past two yrs seemed like an unattainable dream/luxury. Mirtazipine is an anti-depressant usually given at 15mg+ dosage for depression, but at lower doses (<7.5mg) it has a sedative quality.

However, i feel so tired, groggy, foggy and unable to function as it is very sedating. But what are my options? There dont seem to be any, so its kind of the lesser of both evils. I'm just glad that i am able to get more than 1-3hrs sleep a night. Has anyone else Mirtazipine for insomnia?

Offline Peter Staley

  • Member
  • Posts: 1,337
  • Founder & Advisory Editor, AIDSmeds.com
    • AIDSmeds.com
Re: Atripla & Drug interaction
« Reply #14 on: July 02, 2008, 03:10:32 PM »
Delby -- have you discussed switching HIV meds with your doctor?  You shouldn't have to live with this kind of insomnia when there are other choices for HIV meds.  Just swap the Sustiva with a boosted protease inhibitor, and see it that helps.  If not, you can always switch back.

Also, as BreakerOneNine mentioned, you could try taking Atripla in the morning instead.

Offline newone

  • Member
  • Posts: 57
Re: Atripla & Drug interaction
« Reply #15 on: November 23, 2012, 10:24:01 AM »
Hi,
I am about to start using EPI dietary supplements which I should take with Milk Thistle supplements,I have been told that it is dangerous to mix Atripla with Milk Thistle anyone knows if it is ok to use EPI without the Milk T. or even if there is any negative interaction with Atripla and EPI?
Sustiva, Truvada
cd 212 Mar 04
cd 265 May 04 (started meds)
cd 389 Jun  04
cd 504 Oct  04
cd 449 Dec 04
cd 518 Apr 05
cd 449 Nov 05
cd 514 Jan 06
cd 618 Apr 06
cd 665 Jul 06
cd 617 Nov 06
cd 604 Apr 07
cd 956 Aug 07
cd 690 Nov 07 (26%)
cd 771 Apr 08 24%
cd 737 Sep 08 27% Atripla
cd 648 Jan  09 27%
cd 627 Apr 09 25%
cd 607 Oct 09 25%
cd 676 Jan 10 25%
cd 811 Jun 10 25%
cd 922 Nov 10 27%
cd 860 Apr 11 28%
cd 767 Jul 11 24%
cd 843 Oct 11 27%
cd 1350 Jan 12 27%
cd 756   Jun 12 27%
cd 1151 Oct 12 35%
cd 965  Jan 13 36%
cd 875 May 13 32% Eviplera
cd 845 Jul 13  30% und.

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.