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Author Topic: Truvada/Isentress  (Read 3647 times)

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Offline ny1978

  • New Member
  • Posts: 2
Truvada/Isentress
« on: October 21, 2012, 08:45:09 AM »
So I've been on Truvada/Isentress for two years now (previously I was on Trizivir) and I've noticed a steep decline in my ability to obtain/sustain an erection.  It's gotten to the point where I need to use Viagra every time I have sex.  My testosterone levels have checked out normal (690) and I'm relatively young (33).  Has anyone experienced this issue and if so, which drug might be causing it?  I'm trying to decide what new regimen I should switch to and want to make sure I'm eliminating the drug that is causing this issue.  Thanks in advance for your help!

Offline Billy B

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  • Posts: 374
Re: Truvada/Isentress
« Reply #1 on: October 21, 2012, 09:57:44 AM »
So I've been on Truvada/Isentress for two years now (previously I was on Trizivir) and I've noticed a steep decline in my ability to obtain/sustain an erection.  It's gotten to the point where I need to use Viagra every time I have sex.  My testosterone levels have checked out normal (690) and I'm relatively young (33).  Has anyone experienced this issue and if so, which drug might be causing it?  I'm trying to decide what new regimen I should switch to and want to make sure I'm eliminating the drug that is causing this issue.  Thanks in advance for your help!

Welcome to the forum,
I don't mean to appear insensitive but are you really considering changing your meds for this reason? People change med combos because of debilitating side effects or failure to controll the virus.
As you can see in my sig that I have experience with these two drugs and even at my age I had morning wood today and no problems when the time is right. I would dare say that my IDS would laugh his ass off if I asked him to change my meds for the reason you stated.
Billy
VL 4420 CD4 340 CD4% 24   3/15/10 Started I&T
VL  UD   CD4 340 CD4% 26.5 05/13/10
VL  UD   CD4 360 CD4% 27.1 08/3/10
VL  UD   CD4 310 CD4% 28.4 11/22/10
VL  UD   CD4 420 CD4% 27.9 02/11/11
VL  UD   CD4 370 CD4% 26.4 06/08/11
VL  UD   CD4 360 CD4% 27.7 09/23/11
VL  UD   CD4 370 CD4% 28.3 01/20/12
VL  UD   CD4 430 CD4% 28.8 05/11/12
VL  UD   CD4 370 CD4% 28.1 09/07/12
VL  UD   CD4 390 CD4% 32.3 03/14/13

Offline Miss Philicia

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  • Posts: 24,408
  • celebrity poster, faker & poser
Re: Truvada/Isentress
« Reply #2 on: October 21, 2012, 10:13:44 AM »
If my doctor were to conclude that this medication combo was the cause of erectile dysfunction in a thirty-three year old he would not hesitate to try a different drug regimen. He's not so dismissive, nor would I be.

That said, I'm on these medications and haven't had this issue.
"Iíve slept with enough men to know that Iím not gay"

Online buginme2

  • Member
  • Posts: 3,191
Re: Truvada/Isentress
« Reply #3 on: October 21, 2012, 10:22:52 AM »
Abso F'ing lutely.  I hope your DR is doing their best to find the problem.  If it was determined to be either the T/I..I would have not hesitation switching.  There are too many options to be saddled with ED in your early 30's.  good luck!!

Do you smoke?   If so...get help stopping..its a boner killer

Just a side note, Ive been on Atripla and for me it actually causes erections. Go figure.  If you can deal with the crazies its a nice side effect.

« Last Edit: October 21, 2012, 10:39:18 AM by buginme2 »
Don't be fancy, just get dancey

Offline Miss Philicia

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  • celebrity poster, faker & poser
Re: Truvada/Isentress
« Reply #4 on: October 21, 2012, 10:36:44 AM »
Can we also conclude that you're not on any other medication(s) such as an anti-depressant that would be causing this issue? I would assume that your doctor would know, but thought it prudent to ask.
"Iíve slept with enough men to know that Iím not gay"

Offline Billy B

  • Member
  • Posts: 374
Re: Truvada/Isentress
« Reply #5 on: October 21, 2012, 10:44:58 AM »
If my doctor were to conclude that this medication combo was the cause of erectile dysfunction in a thirty-three year old he would not hesitate to try a different drug regimen. He's not so dismissive, nor would I be.

That said, I'm on these medications and haven't had this issue.

Hi Miss P,
Your toilet bowl pics would be enough for me to ask for a change of meds.
Billy
VL 4420 CD4 340 CD4% 24   3/15/10 Started I&T
VL  UD   CD4 340 CD4% 26.5 05/13/10
VL  UD   CD4 360 CD4% 27.1 08/3/10
VL  UD   CD4 310 CD4% 28.4 11/22/10
VL  UD   CD4 420 CD4% 27.9 02/11/11
VL  UD   CD4 370 CD4% 26.4 06/08/11
VL  UD   CD4 360 CD4% 27.7 09/23/11
VL  UD   CD4 370 CD4% 28.3 01/20/12
VL  UD   CD4 430 CD4% 28.8 05/11/12
VL  UD   CD4 370 CD4% 28.1 09/07/12
VL  UD   CD4 390 CD4% 32.3 03/14/13

Offline Miss Philicia

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  • Posts: 24,408
  • celebrity poster, faker & poser
Re: Truvada/Isentress
« Reply #6 on: October 21, 2012, 10:51:05 AM »
Hi Miss P,
Your toilet bowl pics would be enough for me to ask for a change of meds.
Billy

Unfortunately for Miss P, unlike most other people on this forum, my alternatives are limited. However, my doctor has indicated as of my last visit that he wants to switch me to dolutegravir when it's FDA approved. My numbers are too high to get on the clinical trial. But thanks for the concern.
"Iíve slept with enough men to know that Iím not gay"

Offline mikeyb39

  • Member
  • Posts: 946
Re: Truvada/Isentress
« Reply #7 on: October 21, 2012, 11:26:16 AM »
Miss P, do they think you medication is causing your bowel issue?  my roommate has horrible bowel issues.  he eats and has to go straight to the restroom.  he is not positive, he just has stomach problems.  he goes to a doctor that prescribes him expensive probiotics and etc.   of course he doesn't take them like he is supposed to.  just asking, i'm sure you have been to the doctors about it many times.
11/02/2010  cd4-251, vl-591000
12/09/2010  started Atripla
02/18/2011  cd4-425, vl-800
06/10/2011  cd4-447, vl-70
10/10/2011  cd4-666, vl-80
01/05/2012  swiched med (prezista,norvir ,isentress, )
02/10/2012  cd4-733, vl-UD  Viread removed
06/10/2012  cd4-614, vl-UD
12/14/2012  cd4-764, vl-UD
09/01/2013  cd4-785, vl-UD
03/06/2014. cd4- 1078, VL-UD
09/05/2014  cd4-850 , VL-UD

Offline Miss Philicia

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  • Posts: 24,408
  • celebrity poster, faker & poser
Re: Truvada/Isentress
« Reply #8 on: October 21, 2012, 11:40:52 AM »
Mike, I've had this issue ever since I was put on protease inhibitors back in 1997. Off the top of my head I think I've been on four different PI's in the past 15 years. Of course, lots of people have this issue with PIs, but for me I have to take a lot more loperamide to counteract it -- six capsules a day. Usually that's enough to control the issue, but maybe once a week it still happens and then takes 48 hours to clear out. I will say switching to Prezista lessened the issue. I was taking 10 loperamide a day before that.

If your roommate has consistent issues with this he really needs to get used to routinely taking something IMO.
"Iíve slept with enough men to know that Iím not gay"

Offline wolfter

  • Member
  • Posts: 4,700
Re: Truvada/Isentress
« Reply #9 on: October 21, 2012, 01:36:14 PM »
Unfortunately for Miss P, unlike most other people on this forum, my alternatives are limited. However, my doctor has indicated as of my last visit that he wants to switch me to dolutegravir when it's FDA approved. My numbers are too high to get on the clinical trial. But thanks for the concern.

I'm lucky that I don't have the constant problems you do down under.  I too am in the same boat, this combo was my onlyone available because of the numerous combos through the years.  Intelence, Isentress and Truvada. 

I've never experienced erection issues with this combo and would insist upon discussing it with my doctor if it happened, especially if there other options available. 
Complacency is the enemy.  ;)  Challenge yourself daily for maximum  return on investment.

Offline jkinatl2

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  • Posts: 6,007
  • Doo. Dah. Dipp-ity.
Re: Truvada/Isentress
« Reply #10 on: October 21, 2012, 02:56:58 PM »
I know that if it was determined that my meds were causing erectile dysfunction, I would not hesitate to demand a change. That's a quality of life issue every bit as much as lipo, for those of us who have a relatively high sex drive. And by relatively, in my case I mean that of a young Bonobo.

That having been said, I am on Isentress/Truvada/Norvir/Prezista and have not encountered erectile dysfunction. Which is good because legal viagra is scary expensive and not covered under my insurance, last I checked.

I understand the impulse to dismiss the sex stuff as unimportant, especially among those of us who saw the worst of the pandemic - and the worst of the medication-related side effects (and who may still experience those today.)

Color me greedy, but after 19 years and six months with AIDS, not dying is not enough.

Also, welcome to the forums, ny1978!

"Many people, especially in the gay community, turn to oral sex as a safer alternative in the age of AIDS. And with HIV rates rising, people need to remember that oral sex is safer sex. It's a reasonable alternative."

-Kimberly Page-Shafer, PhD, MPH

Welcome Thread

Offline ny1978

  • New Member
  • Posts: 2
Re: Truvada/Isentress
« Reply #11 on: October 21, 2012, 09:18:22 PM »
Hey, thanks for everyone's responses (well, except for the guy who doesn't seem to realize how psychologically debilitating it is to lose your sex drive at 33).  My doctor can't seem to find any other reason for the low sex drive (the only other drug I take is Lunesta, which I've taken for 8 years without issue).  So the Truvada/Isentress is the only remaining cause.  I'm switching to Atripla but I'm obviously hesitant abt this due to its CNS effects.  Hopefully tho, those will be manageable and my sex drive will return!

Offline littleprince

  • Member
  • Posts: 201
Re: Truvada/Isentress
« Reply #12 on: October 22, 2012, 02:32:10 PM »
Welcome to the forum,
I don't mean to appear insensitive but are you really considering changing your meds for this reason? People change med combos because of debilitating side effects or failure to controll the virus.
As you can see in my sig that I have experience with these two drugs and even at my age I had morning wood today and no problems when the time is right. I would dare say that my IDS would laugh his ass off if I asked him to change my meds for the reason you stated.
Billy

Billy,

1. Drug changes are not only done after viral load failure or debilitating side effects. It's also done to improve quality of life. Why should someone put up with something if a simple switch of meds will help them? Granted it's not done lightly and there are risks but if something is affecting you enough a Dr is not going to force you to stay on the old meds. Changes are even done to reduce the number of tablets and/or doses per day so why wouldn't it be done to help a medical problem?

2. ED is a serious problem and you won't find a single Dr that will brush it off as you did. I can assure you that your Dr would not 'laugh his ass off'. He would treat the problem with some maturity.

3. It's extremely rude of you to make light of another persons problem, especially when you then turn around and point out that you have no problems from your meds only showing that you have no idea what you are talking about on the topic.

Offline WindySkies

  • Member
  • Posts: 113
  • Tested + 10/11/12
Re: Truvada/Isentress
« Reply #13 on: October 22, 2012, 03:18:12 PM »
Hey, thanks for everyone's responses (well, except for the guy who doesn't seem to realize how psychologically debilitating it is to lose your sex drive at 33).  My doctor can't seem to find any other reason for the low sex drive (the only other drug I take is Lunesta, which I've taken for 8 years without issue).  So the Truvada/Isentress is the only remaining cause.  I'm switching to Atripla but I'm obviously hesitant abt this due to its CNS effects.  Hopefully tho, those will be manageable and my sex drive will return!

Since you are concerned about the side effects of the Atripla, have you considered any other medication?  My doctor specifically recommended Complera because he doesn't think the side effects of Atripla are worth it.  Complera doesn't have the same effects and it is a once a day single pill as well.

In regards to the ED issue, it's a quality of life thing as well, don't we all want to feel as normal as possible!  If your doctor laughs at you, I would walk out and find a more serious doctor.  Whatever you end up doing, I hope it work for you.
10/11/2012 Journey Started
10/17/2012 First Labs: VL=57,645  CD4+=730  37%
10/31/2012 Started Complera
11/30/2012 Labs: VL=80  CD4+=929 40%
12/24/2012 Started Stribild

Undetectable since 1/15/13 CD4+= Over 1,400 and 49%

Offline mecch

  • Member
  • Posts: 12,024
  • red pill? or blue pill?
Re: Truvada/Isentress
« Reply #14 on: October 22, 2012, 04:33:49 PM »
Welcome to the forum,
I don't mean to appear insensitive but are you really considering changing your meds for this reason? People change med combos because of debilitating side effects or failure to controll the virus.
As you can see in my sig that I have experience with these two drugs and even at my age I had morning wood today and no problems when the time is right. I would dare say that my IDS would laugh his ass off if I asked him to change my meds for the reason you stated.
Billy

I agree with Miss P.  This post is incredibly dismissive.  Who are you to say doctors laugh at impotence????!!!!

ďFrom each, according to his ability; to each, according to his needĒ 1875 K Marx

Offline Billy B

  • Member
  • Posts: 374
Re: Truvada/Isentress
« Reply #15 on: October 23, 2012, 11:11:14 AM »
Sorry some of you thought my response to the op was dismissive, BUT he is still able to achieve an erection with the help of Viagra. With ALL the side effects that LTS and people new to this forum have endured, a problem with the little guy is just not that big of a deal. Viagra works for him just like some other additional meds are needed for the problems caused by the meds that some take.
Since I have never seen another post or read any information about Isentress & Truvada causing ED I sure hope that ny1978 will contact the manufacturers. I personally would not ditch a class of meds that were working well except for a condition that can be alleviated with the little blue pill.
Is this a case of the little head controlling the big head?
Billy
« Last Edit: October 23, 2012, 11:14:59 AM by Billy B »
VL 4420 CD4 340 CD4% 24   3/15/10 Started I&T
VL  UD   CD4 340 CD4% 26.5 05/13/10
VL  UD   CD4 360 CD4% 27.1 08/3/10
VL  UD   CD4 310 CD4% 28.4 11/22/10
VL  UD   CD4 420 CD4% 27.9 02/11/11
VL  UD   CD4 370 CD4% 26.4 06/08/11
VL  UD   CD4 360 CD4% 27.7 09/23/11
VL  UD   CD4 370 CD4% 28.3 01/20/12
VL  UD   CD4 430 CD4% 28.8 05/11/12
VL  UD   CD4 370 CD4% 28.1 09/07/12
VL  UD   CD4 390 CD4% 32.3 03/14/13

Offline mecch

  • Member
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  • red pill? or blue pill?
Re: Truvada/Isentress
« Reply #16 on: October 23, 2012, 11:56:07 AM »
Sorry some of you thought my response to the op was dismissive, BUT he is still able to achieve an erection with the help of Viagra. With ALL the side effects that LTS and people new to this forum have endured, a problem with the little guy is just not that big of a deal. Viagra works for him just like some other additional meds are needed for the problems caused by the meds that some take.
Since I have never seen another post or read any information about Isentress & Truvada causing ED I sure hope that ny1978 will contact the manufacturers. I personally would not ditch a class of meds that were working well except for a condition that can be alleviated with the little blue pill.
Is this a case of the little head controlling the big head?
Billy

The OP is 33.  There is no indication whatsoever he is a LTS.... Highly unlikely given his age.  Also, no indication of any other troubles or side effects with his HAART.
So who knows if the HAART has anything to do with his ED.  Thats for a specialist to figure out. 

And surely no specialist is going to dismiss it.

You applied irrelevant hunches and experiences to his situation.  Your post was dismissive and you should eat crow.  ::)
« Last Edit: October 23, 2012, 12:00:37 PM by mecch »
ďFrom each, according to his ability; to each, according to his needĒ 1875 K Marx

Offline newt

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  • the one and original newt
Re: Truvada/Isentress
« Reply #17 on: October 23, 2012, 12:22:03 PM »
Given that ED can be a symptom of nerve damage, and Isentress, esp combined with the tenofovir in Truvada, can sometimes cause this, this is not for simply a matter of getting it up, but something further investigation with the medics.

- matt
"The object is to be a well patient, not a good patient"

Offline wolfter

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  • Posts: 4,700
Re: Truvada/Isentress
« Reply #18 on: October 23, 2012, 12:33:17 PM »
Sorry some of you thought my response to the op was dismissive, BUT he is still able to achieve an erection with the help of Viagra. With ALL the side effects that LTS and people new to this forum have endured, a problem with the little guy is just not that big of a deal. Viagra works for him just like some other additional meds are needed for the problems caused by the meds that some take.
Since I have never seen another post or read any information about Isentress & Truvada causing ED I sure hope that ny1978 will contact the manufacturers. I personally would not ditch a class of meds that were working well except for a condition that can be alleviated with the little blue pill.
Is this a case of the little head controlling the big head?
Billy

QUICK, dig deeper. :o
Complacency is the enemy.  ;)  Challenge yourself daily for maximum  return on investment.

Offline Billy B

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Re: Truvada/Isentress
« Reply #19 on: October 23, 2012, 12:58:13 PM »
mecch,
Please reread, I wrote  "LTS and people new to this forum have endured". I did not say he was. The fact that he doesn't have any other troubles except that he might feel emasculated just doesn't cut it with me as a reason the change meds especially when he can use Viagra. I think that in his OP that the problem with Viagra was the cost not that it did not work.

This will be my last post on this subject as I feel some of your are just looking for an argument to entertain yourselves (except Matt) so there!
Billy
« Last Edit: October 23, 2012, 01:05:01 PM by Billy B »
VL 4420 CD4 340 CD4% 24   3/15/10 Started I&T
VL  UD   CD4 340 CD4% 26.5 05/13/10
VL  UD   CD4 360 CD4% 27.1 08/3/10
VL  UD   CD4 310 CD4% 28.4 11/22/10
VL  UD   CD4 420 CD4% 27.9 02/11/11
VL  UD   CD4 370 CD4% 26.4 06/08/11
VL  UD   CD4 360 CD4% 27.7 09/23/11
VL  UD   CD4 370 CD4% 28.3 01/20/12
VL  UD   CD4 430 CD4% 28.8 05/11/12
VL  UD   CD4 370 CD4% 28.1 09/07/12
VL  UD   CD4 390 CD4% 32.3 03/14/13

Offline mecch

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  • red pill? or blue pill?
Re: Truvada/Isentress
« Reply #20 on: October 23, 2012, 01:10:43 PM »
except that he might feel emasculated just doesn't cut it with me as a reason the change meds especially when he can use Viagra. I think that in his OP that the problem with Viagra was the cost not that it did not work.

lol

http://www.youtube.com/watch?v=sJV29ZQIUhs
ďFrom each, according to his ability; to each, according to his needĒ 1875 K Marx

Offline littleprince

  • Member
  • Posts: 201
Re: Truvada/Isentress
« Reply #21 on: October 26, 2012, 04:34:37 PM »

This will be my last post on this subject...



Good. It's not that people are looking for an argument, they are pointing out that you are being insensitive and are totally off the mark. If you can't see that then it's for the best that you stop commenting because every time you open your mouth you seem to give the OP a back hand.

Offline harleymc

  • Member
  • Posts: 244
Re: Truvada/Isentress
« Reply #22 on: October 27, 2012, 05:39:40 PM »
I'm on Isentress, truvada and Kaletra, I found that I have less of an issue with erectile disfunction than before being on this combo. I'd be hesitant to assume that the medication regime is the cause of the issue.

You need to be really persistant with your MD. Erectile disfunction can be a symptom of circulatory issues, the fact that Viagra works for you suggests this is a circulation issue. Get this checked out you don't want to have an unecessary heart attack.


 


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