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Author Topic: Viramune break in period for treatment experience  (Read 728 times)

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Offline Anqueetas

  • Member
  • Posts: 116
Viramune break in period for treatment experience
« on: October 27, 2012, 12:24:30 PM »
Hello again, from my previous question on safety of switching to Viramune while have high CD4 and on HAART. I finally get my doctor to prescribe it and start taking VIramune for 4 days now. He said to do once a day dosage for 14 days but I heard many of you who switch don't do the full 14 days.

1.What is your experience when switching? do you do the whole 14 days lead in dosage? (once a day)

2. Worried that when I do the 14 days lead it period I can develop resistance to the drug from insufficient Viramune concentration in the blood, is this possible?

Thank you for answering.
ARS, hospitalized for very high fever-July 2011
diagnosed HIV positive - October 16 2011
CD4 460 19.5% VL 49000 - late October 2011
CD4 625 19.5% VL 50030 - January 2012
CD4 369 19% VL 69000 - March 2012
Start Sustiva+ Truvada - April 17 2012
CD4 524 24.5% VL UD - August 22 2012
Switch to Nevirapine+Truvada
CD4 490 26% VL UD - November 2012
CD4 539 29% VL UD - February 2013
CD4 621 28% VL UD - May 2013

Offline eric48

  • Member
  • Posts: 1,207
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
Re: Viramune break in period for treatment experience
« Reply #1 on: October 27, 2012, 08:34:57 PM »

No one (to my knowledge) in this forum is an MD. Ask your doctor (or any other viramune expeerienced doc). he is paid to answer this kind of question. The start period was introduced as sudden death of patients had been observed (in very limited cases). Since this has been implemented, I think it has proven successful.

When I started Viramune (I was treatment naive), my doc insisted that I shoukd wait for 15 days AND come to a visit at 15 days sharp, with complete liver enzymes panel so that he can give the thumbs up.

Since you are UD and Drug concentration from your previous NNRTI will go down slowly, there should not be any real threat for virologic failure. Liver failure is also extremely rare.

So take it easy...

Welcome to the Viramune users club

Eric
NVP/ABC/3TC/... UD; CD4 > 1000; CD4/CD8 ~ 2.0   safety stock : 3 months (2013: FOTO= 5d. ON 2d. OFF ; 2014: NCT02157311 = 4d. ON, 3d. OFF)

Offline Anqueetas

  • Member
  • Posts: 116
Re: Viramune break in period for treatment experience
« Reply #2 on: October 29, 2012, 05:20:55 AM »
No one (to my knowledge) in this forum is an MD. Ask your doctor (or any other viramune expeerienced doc). he is paid to answer this kind of question. The start period was introduced as sudden death of patients had been observed (in very limited cases). Since this has been implemented, I think it has proven successful.

When I started Viramune (I was treatment naive), my doc insisted that I shoukd wait for 15 days AND come to a visit at 15 days sharp, with complete liver enzymes panel so that he can give the thumbs up.

Since you are UD and Drug concentration from your previous NNRTI will go down slowly, there should not be any real threat for virologic failure. Liver failure is also extremely rare.

So take it easy...

Welcome to the Viramune users club

Eric


THx again Eric, I guess i shouldn't rush things.
ARS, hospitalized for very high fever-July 2011
diagnosed HIV positive - October 16 2011
CD4 460 19.5% VL 49000 - late October 2011
CD4 625 19.5% VL 50030 - January 2012
CD4 369 19% VL 69000 - March 2012
Start Sustiva+ Truvada - April 17 2012
CD4 524 24.5% VL UD - August 22 2012
Switch to Nevirapine+Truvada
CD4 490 26% VL UD - November 2012
CD4 539 29% VL UD - February 2013
CD4 621 28% VL UD - May 2013

 


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