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Author Topic: Aptima  (Read 1587 times)

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Offline lydgate

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« on: October 08, 2006, 04:13:25 AM »
Can someone tell me more about this "new" FDA-approved test? Insoafar as I can tell, it seems to be an antigen test that's been around for a while -- the PCR qualitative. That test has never been approved for diagnostic purposes. If, in fact, the qualitative PCR antigen test has been approved now for diagnostic purposes, does anyone know why the change? Better test technology -- greater specificity, fewer false positives? A pragamatic decision by the FDA for a faster (window-period-independent) diagnostic tool? Or is this test genuinely new, different technology, a diagnostic breakthrough?

Her finely-touched spirit had still its fine issues, though they were not widely visible. Her full nature, like that river of which Cyrus broke the strength, spent itself in channels which had no great name on the earth. But the effect of her being on those around her was incalculably diffusive: for the growing good of the world is partly dependent on unhistoric acts; and that things are not so ill with you and me as they might have been, is half owing to the number who lived faithfully a hidden life, and rest in unvisited tombs.

George Eliot, Middlemarch, final paragraph

Offline newt

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Re: Aptima
« Reply #1 on: October 08, 2006, 04:21:32 AM »
Aptima is a brand name for a dead good RNA test made by Gen-Probe for the qualitative detection (ie, is it there or not?) of Chlamydia trachomatis and Neisseria gonorrhoeae infections. Gen-Probe is something of a specialist in easy-to-use RNA screening tests. 

The new Aptima HIV and HCV RNA tests will give a quick way to tell if RNA from these virus is present, therefore may be a useful tool for rapid screening in clinics.  I imagine a positive result for HIV/HCV will require confirmation by another, different test.

Being RNA based, it may help detect acute/primary infection before antibodies are present.  For HIV, it will also be a useful extra test if done at the same time as an antibody test, for the purpose of weeding out the very few false positives that antibody tests produce (ie, positve antibody test but no RNA = no infection).

- matt

Now playing: Ben Taylor, Safe Enough to Wake Up
« Last Edit: October 08, 2006, 04:33:00 AM by newt »
"The object is to be a well patient, not a good patient"


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