Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
August 30, 2014, 02:55:10 AM

Login with username, password and session length


Members
  • Total Members: 23344
  • Latest: TML1991
Stats
  • Total Posts: 636620
  • Total Topics: 48318
  • Online Today: 171
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online
Users: 5
Guests: 120
Total: 125

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: combination Pills  (Read 1427 times)

0 Members and 1 Guest are viewing this topic.

Offline james3000

  • Member
  • Posts: 140
combination Pills
« on: September 18, 2012, 03:19:23 PM »
Hi,

I was wondering if anyone knows why all the combination pills have Emtricitabine in them ?

Thanks.

Offline mikeyb39

  • Member
  • Posts: 922
Re: combination Pills
« Reply #1 on: September 19, 2012, 09:02:35 AM »
Well basically none of them are completely new, they just are able to combine whats already out into one pill.  most of these once day pills can be taken indepentally with the exception of Compleara.  I think the only thing 'new' in the Quad' pill is a new Intergrase Inhibitor, which looks almost exactly like Isentress.

I'd like to see something new and 'different' that can help with less medication and side-effects.
11/02/2010  cd4-251, vl-591000
12/09/2010  started Atripla
02/18/2011  cd4-425, vl-800
06/10/2011  cd4-447, vl-70
10/10/2011  cd4-666, vl-80
01/05/2012  swiched med (prezista,norvir ,isentress, )
02/10/2012  cd4-733, vl-UD  Viread removed
06/10/2012  cd4-614, vl-UD
12/14/2012  cd4-764, vl-UD
09/01/2013  cd4-785, vl-UD
03/06/2014. cd4- 1078, VL-UD

Offline eric48

  • Member
  • Posts: 1,165
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
Re: combination Pills
« Reply #2 on: September 19, 2012, 05:15:49 PM »
why all the combination pills have Emtricitabine in them

First, this is not entirely true. Emtricitabine (aka FTC) is used in most combo.

one alternative (less) commonly used is 3TC.

One could argue, though, that FTC and 3TC are considered chemically and virologically very close, if not 'similar'

Then it becomes true that FTC OR its cousin 3TC is used in almost all combos.

This is becuase there are 'good', proven NRTIs. and most regimen iclude NRTI as a backbone.

NRTIs sparing regimen are quite few and usually PIs

New classes (integrase inhibitors or CCR5 blockers) have been successfully only when used with NRTIs

which is why, here:
http://www.thebodypro.com/content/67445/spartan-two-drug-nrti-sparing-strategies-continue.html

asks himself :

Do the NRTIs provide some key antiviral component mechanistically?

I am not too much into exotic combo but, as far as I know, the first PIs sparring AND NRTIs sparring combo was tried here, very recently here :

http://www.ncbi.nlm.nih.gov/pubmed/22941896

choosing the PI route or the NRTI route is set by the resistance test and doctor/patient preference and profile. Except for the above mentionned one, it is either one route or the other.

And if the route includes NRTIs, statiscally a vast majority of users will take either FTC or its very close cousin 3TC.

As why FTC is more used in 3-drug combinaison single dosing pills, I think it comes down to patent ownership and big Pharma business strategies

Hope this helps

Eric
« Last Edit: September 19, 2012, 05:18:51 PM by eric48 »
NVP/ABC/3TC/... UD; CD4 > 1000; CD4/CD8 ~ 2.0   safety stock : 2 months

Offline james3000

  • Member
  • Posts: 140
Re: combination Pills
« Reply #3 on: September 20, 2012, 02:51:40 PM »
Thanks for both your replies

I am drug resistant to Emtricitabine and am taking double amount of pills. One pill twice daily would be great. I was hoping they would do one 3tc in it.

Thanks

Offline newt

  • Member
  • Posts: 3,878
  • the one and original newt
Re: combination Pills
« Reply #4 on: September 20, 2012, 07:51:03 PM »
FTC (emtricitabine) and 3TC are basically sister drugs. If you are resistant to one you wil be resistant to the other. Taking a double dose  of FTC won't help.

However, if you have the common M184V mutation that gives 100% resistance to FTC and 3TC and are taking tenofovir it doesn't matter. M184V virus is extra-susceptible to tenofovir, and this usually overcomes the M184V resistance.

- matt
"The object is to be a well patient, not a good patient"

Offline james3000

  • Member
  • Posts: 140
Re: combination Pills
« Reply #5 on: September 21, 2012, 08:42:49 PM »
Sorry I was not very clear ,I am taking one pill of 3tc a day maybe I should switch to something else as the ID dr said I was drug resistant to Ftc they said that's why I am not on the 1 pill a day option

Offline newt

  • Member
  • Posts: 3,878
  • the one and original newt
Re: combination Pills
« Reply #6 on: September 24, 2012, 06:27:32 PM »
3TC and FTC more or less share the same resistance profile. What else are you on? - matt
« Last Edit: September 24, 2012, 06:32:27 PM by newt »
"The object is to be a well patient, not a good patient"

Offline james3000

  • Member
  • Posts: 140
Re: combination Pills
« Reply #7 on: September 25, 2012, 07:45:54 AM »
Hi Matt,

I am on

3tc 1 a day
isentress    4 pills a day  taken 2 in morning and 2 in evening
intellence    4 pills a day take 2 in morning 2 in evening
norvir 2 pills a day 1 in morning and evening
Prezista 2 pills a day taken in morning and evening

Thanks James

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.