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Lower viral load for Vacc-4x injected patients off ART 1 year

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PerfectlyHuman:
So if the person already had an undetectable viral load does it mean the vaccine will keep him undetectable indefinitely? I'm basing this off of Common Ground's first comments.

Jmarksto:
Binor Pharma's most recent news release on the Vacc-4x reboost is here:

 http://tinyurl.com/bkq6wak

The press release summary is:

05.12.2012 - Final Approvals Received for International Study to Reboost Patients From the Completed Vacc-4x Phase II Trial

Approximately 40 Patients Will Participate at 11 Clinics in USA and Europe

News Summary

  * Study design: Open, clinical phase II study, with two Vacc-4x immunizations
    while patients remain on conventional HIV medication (Antiretroviral
    Therapy, ART), followed by up to 16 weeks of treatment interruption

  * Primary endpoints: Changes in viral load compared to the previous study, and
    immune responses to the vaccine

  * Aim of the study: To determine whether a lower viral load level ("set
    point") can be achieved by reboosting previously Vacc-4x vaccinated HIV
    infected patients, indicating a potential for "stair stepping" down viral
    load through "booster" injections

  * Funding from GLOBVAC: Bionor Pharma was awarded NOK 10.48M/US$1.85M from
    Globvac in July 2012, primarily to fund the reboost study

YellowFever:
Hrm, It still looks like there's alot more work to do before it can become a viable alternative to HAART.

I pulled a random paper published in lancet to find the statistics on VL in treatment naive patients (4.49 log). A vaccine (or a series/combination of vaccines) would need to show at least a 2.8 log reduction in VL in order to get a treatment naive person down to UD (i.e < 50). But nonetheless, we're inching there. :D

Random Paper: http://www.hcv.ch/updown/documents/publ/1999/ledergerber_1999_lancet.pdf

Math: log1050 = 1.69

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