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Author Topic: Quad approved  (Read 3336 times)

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Offline buginme2

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Quad approved
« on: August 27, 2012, 07:26:47 PM »
And it will from here on out be called Stribild.  I liked Quad better.

http://www.reuters.com/article/2012/08/27/us-gilead-hiv-idUSBRE87Q16620120827
« Last Edit: August 27, 2012, 07:28:58 PM by buginme2 »
"All I need are some tasty waves, a cool buzz, and I'm fine."

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Offline jimbalaya

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Re: Quad approved
« Reply #1 on: August 27, 2012, 09:16:24 PM »
I actually have an appointment in two days to meet with my ID doc...I'm curious to hear what his thoughts are on this drug.   Thanks for sharing the link.    ;D

Offline Dr.Strangelove

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Re: Quad approved
« Reply #2 on: August 28, 2012, 04:35:42 AM »
Stribild? Indeed a strange name. Not that I got a problem with strange but still.

Is there any news on the (over)pricing?

Offline Ann

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Re: Quad approved
« Reply #3 on: August 28, 2012, 05:41:25 AM »
[rant=looselyrelated]

Just what we need, another drug name to learn/remember. It drives me nuts. Most hiv meds have two, if not three and sometimes four, different names.

Here everyone usually uses the brand name. My doctor always uses the generic name so I have to learn both to be able to converse here and with him as well - because he can never remember the brand name. Arrgh!

I don't know about the rest of you, but when I first started learning about the meds one of the things I found the most daunting was remembering the multiple names of each drug. I still get them mixed up at times and often have to double-check to be 100% sure. Did I mention that it drives me NUTS?

Around ten years ago when I was first trying to learn all the names, I put them on some index cards I found lying around. One side was the generic and abbreviated name (ie ABC or 3TC) and the other side was the brand name. Ugh. Hiv med flash cards. How geeky is that? :-\

And now that we're getting more and more multi-drug, multi-class pills, we get people referring to their component parts by their brand names or their generic names - and sometimes a combination of both. 

And don't get me started on all the additional generic brand names like Viraday (generic Atripla).

No wonder newbies get confused.

[/rant]

I agree that it's an odd name (maybe that will help me remember it) - because of the bild, it makes me think a German-speaker came up with it. Sounds Germanic to me, anyway.

What was wrong with Quad? ???
Condoms are a girl's best friend

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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline wolfter

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Re: Quad approved
« Reply #4 on: August 28, 2012, 05:53:06 AM »
Trying using my method; it really works.  My combination is 2 white ones, 1 blue one and 1 pink one. ;D

Wolfie
Judging someone does not define them, it defines you. 

True peace is not merely the absence of war, it is the presence of justice.

Offline Common_ground

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Re: Quad approved
« Reply #5 on: August 28, 2012, 06:17:16 AM »
Stribild, odd name...

Price seems to be around 28 - 29K USD / year although not yet officially announced.

http://www.nytimes.com/2012/08/28/business/fda-approves-once-a-day-pill-for-hiv.html

Is it too much? From what I understand this is the free market price. Gilead will subsidize for ADAP and Ryan White and transfer formulas for generic pills to manufacturers in developing countries. "Stril".... :P
2011 May - Neg.
2012 June CD4:205, 16% VL:2676 Start Truvada/Stocrin
2012 July  CD4:234, 18% VL:88
2012 Sep  CD4:238, 17% VL:UD
2013 Feb  CD4:257, 24% VL:UD -viramune/truvada
2013 May CD4:276, 26% VL:UD

Offline Ann

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Re: Quad approved
« Reply #6 on: August 28, 2012, 06:38:04 AM »
I always thought they'd go with something like Quadravir.
Condoms are a girl's best friend

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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Miss Philicia

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Re: Quad approved
« Reply #7 on: August 28, 2012, 06:39:24 AM »
The should name it Haris Pilton.
"Iíve slept with enough men to know that Iím not gay"

Offline phildinftlaudy

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Re: Quad approved
« Reply #8 on: August 28, 2012, 07:06:54 AM »
I was kind of hoping they would name it "Four-play"

Captures the quad and still a little quirky -
Also, fits nicely onto an index card.... for Ann's benefit  ;)
September 13, 2008 - diagnosed +
Labs:
Date    CD4    %   VL     Date  CD4  %   VL
10/08  636    35  510   9/09 473  38 2900  12/4/09 Atripla
12/09  540    30    60   
12/10  740    41  <48   
8/11    667    36  <20  
03/12  1,041  42  <20
05/12  1,241  47  <20
08/12   780    37  <20
11/12   549    35  <20
02/12  1,102  42  <20
11/12   549    35  <20

Offline bocker3

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Re: Quad approved
« Reply #9 on: August 28, 2012, 10:41:15 AM »
Remember, back in the day-- people would have given their left arms for even one effective med -- of any name.  It's nice to be living in a time when we get to complain about all the names to remember.  Just sayin..........

Mike
Atripla - Started 12/05
Reyataz/Norvir - Added 6/06
Labs - Pre-Meds
Sep05 T=350/25% VL98,559
Nov05 288/18%  47,564
Current Labs
May2013 691/31% <20

Offline Newguy

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Re: Quad approved
« Reply #10 on: August 28, 2012, 12:14:44 PM »
Bocker says:

"Remember, back in the day-- people would have given their left arms for even one effective med -- of any name.  It's nice to be living in a time when we get to complain about all the names to remember.  Just sayin.........."

No I do not remember because I was too young at that time. I also do not remember when woman were not aloud to vote, when many innocent people died in WW2, when the black plague wiped out millions, when black people couldn't ride at the front of the bus. There are sadly an infinite number of instances of human suffering that I do not want to remember but I certainly do not want to forget.

Just Saying




Offline newt

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Re: Quad approved
« Reply #11 on: August 28, 2012, 12:18:07 PM »
You have insurance companies that are happy to cough up the +36% dollars over the price of Atripla for the same clinical effect? hmmmm

As a UK commentator said "Quad is a formulation of four compounds, all developed by Gilead: elvitegravir, cobicistat, tenofovir and FTC. It is a once-daily treatment, and can be taken with or without caviar."

- matt
« Last Edit: August 28, 2012, 12:19:52 PM by newt »
"The object is to be a well patient, not a good patient"

Offline Common_ground

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Re: Quad approved
« Reply #12 on: August 28, 2012, 01:05:24 PM »
From a clinical view.

I would be interesting to know whats going in the R&D departments of the big pharmas. Diagnosed today(maybe even folks with resistance now can go on Stribild) and it is a good chance you can go on with a once-a-day regimen, most reach undetectable fairly quick, CD4 goes up and people get on with their lives. How much better can the meds, as we know them today, get?

Just looking at the insert of any drugs and there will be warnings about possible side effects and adverse reactions. I just doubt there will be ARVs more effective than what we have today. Im not neglecting that people have issues but even without HIV health problems can and will arise.

2011 May - Neg.
2012 June CD4:205, 16% VL:2676 Start Truvada/Stocrin
2012 July  CD4:234, 18% VL:88
2012 Sep  CD4:238, 17% VL:UD
2013 Feb  CD4:257, 24% VL:UD -viramune/truvada
2013 May CD4:276, 26% VL:UD

Offline wolfter

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Re: Quad approved
« Reply #13 on: August 28, 2012, 02:03:15 PM »
Bocker says:

"Remember, back in the day-- people would have given their left arms for even one effective med -- of any name.  It's nice to be living in a time when we get to complain about all the names to remember.  Just sayin.........."

No I do not remember because I was too young at that time. I also do not remember when woman were not aloud to vote, when many innocent people died in WW2, when the black plague wiped out millions, when black people couldn't ride at the front of the bus. There are sadly an infinite number of instances of human suffering that I do not want to remember but I certainly do not want to forget.

Just Saying

I think you misunderstood what a fellow LTS meant by his comment.  It is a great thing to worry about all the names of the numerous effective medications as they were NONE when we were given the horrific news of a short life expectancy.

Not sure why you took exception to his comment and your reply had a snarky ring to it.

just sayin.

Wolfie
Judging someone does not define them, it defines you. 

True peace is not merely the absence of war, it is the presence of justice.

Offline Jmarksto

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  • Posts: 388
Re: Quad approved
« Reply #14 on: August 28, 2012, 04:37:25 PM »
From a clinical view.

I would be interesting to know whats going in the R&D departments of the big pharmas. Diagnosed today(maybe even folks with resistance now can go on Stribild) and it is a good chance you can go on with a once-a-day regimen, most reach undetectable fairly quick, CD4 goes up and people get on with their lives. How much better can the meds, as we know them today, get?

Just looking at the insert of any drugs and there will be warnings about possible side effects and adverse reactions. I just doubt there will be ARVs more effective than what we have today. Im not neglecting that people have issues but even without HIV health problems can and will arise.



Agreed -- meds are very good and I am very thankful.  However, only 1 in 4 in the US are "under control", and fewer globaly.  There are still folks that have challenges afording the meds, with the daily regimen, etc.  Hopefuly we continue to see advances - like a longer acting (weekly, monthly) and less expensive alternatives.

JM
03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45%  VL 25
02/25/14 CD4   792/37%  VL UD

Offline LM

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Re: Quad approved
« Reply #15 on: August 28, 2012, 06:09:09 PM »
You have insurance companies that are happy to cough up the +36% dollars over the price of Atripla for the same clinical effect? hmmmm

As a UK commentator said "Quad is a formulation of four compounds, all developed by Gilead: elvitegravir, cobicistat, tenofovir and FTC. It is a once-daily treatment, and can be taken with or without caviar."

- matt


Ha! Loved it!

The US is run by corporations. Of course they will adopt this, regardless of the price. Too bad for the rest of the world.

Offline Ann

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Re: Quad approved
« Reply #16 on: August 29, 2012, 04:55:53 AM »
Remember, back in the day-- people would have given their left arms for even one effective med -- of any name.  It's nice to be living in a time when we get to complain about all the names to remember.  Just sayin..........

Mike

I totally agree. I'm grateful that we have all these meds, even if it does come with the frustration of having so many different names for single meds as well as for combo (one pill) meds. It's something we now have the luxury of grousing about and even poking a little fun at.

However, in no way does that disrespect the memory, the history of this pandemic. Because that's what I felt like you were "Just sayin........."
Condoms are a girl's best friend

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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline bocker3

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Re: Quad approved
« Reply #17 on: August 29, 2012, 10:05:29 AM »
However, in no way does that disrespect the memory, the history of this pandemic. Because that's what I felt like you were "Just sayin........."

Oh no Ann -- I was not saying that at all.  Although, in hindsight, I can see how that was one way to take it.  I was merely pointing out that we are in a far better place when remembering the drug names is actually an issue.

Hugs,
Mike
Atripla - Started 12/05
Reyataz/Norvir - Added 6/06
Labs - Pre-Meds
Sep05 T=350/25% VL98,559
Nov05 288/18%  47,564
Current Labs
May2013 691/31% <20

Offline Ann

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Re: Quad approved
« Reply #18 on: August 29, 2012, 10:20:13 AM »
Thanks Mike. I did read the just sayin as sarcasm - bloody internet. I'm glad that wasn't your intent.
Condoms are a girl's best friend

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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Dr.Strangelove

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Re: Quad approved
« Reply #19 on: August 29, 2012, 09:05:42 PM »
Btw this is the article with the caviar comment.
I share their criticism about Gilead's pricing.
Quad's medical benefits over other existing medications is small and doesn't justify a +30% price tag (over Atripla).
The other benefits of Quad are merely convenience (doesn't have to be taken with a 400kcal meal...)

Offline Ann

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Re: Quad approved
« Reply #20 on: August 30, 2012, 05:53:49 AM »
I think a world-wide boycott of Quadravir Quadrophenia ...er... Stribild would fix Gilead's wagon. Wonder how difficult it would be to get doctors to not prescribe it?
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Miss Philicia

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Re: Quad approved
« Reply #21 on: August 30, 2012, 07:35:28 AM »
I pay (or rather Medicare pays) $46,311.24 per year for my HIV (only) medications. What's the yearly cost of this new drug versus Atripla? $29,000 versus (?) $20,000

Such quibbling!
"Iíve slept with enough men to know that Iím not gay"

Offline Ann

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Re: Quad approved
« Reply #22 on: August 30, 2012, 08:23:58 AM »
I pay (or rather Medicare pays) $46,311.24 per year for my HIV (only) medications. What's the yearly cost of this new drug versus Atripla? $29,000 versus (?) $20,000

Such quibbling!

Maybe the NHS gets Atripla a lot cheaper than people can elsewhere. From the article linked to above;

"The annual wholesale list price for Quad is expected to be close to $28,500 (approximately £18,000). The list price for Atripla in the UK is just over £7,500 (British National Formulary)."

Looks like a substantial difference from this side of the pond.
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Miss Philicia

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Re: Quad approved
« Reply #23 on: August 30, 2012, 09:24:52 AM »

Looks like a substantial difference from this side of the pond.

Well, yeah -- of course it looks like that on "that side of the pond". It's subsidized by US insurance customers.
"Iíve slept with enough men to know that Iím not gay"

Offline Ann

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Re: Quad approved
« Reply #24 on: August 30, 2012, 10:46:05 AM »
Well, yeah -- of course it looks like that on "that side of the pond". It's subsidized by US insurance customers.

Been drinking the kool-aid, dear?
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Miss Philicia

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Re: Quad approved
« Reply #25 on: August 30, 2012, 11:00:22 AM »
Been drinking the kool-aid, dear?


So if the US had a NHS style price structure for pharmaceuticals how would effect the prices the UK pays?
"Iíve slept with enough men to know that Iím not gay"

Offline Ann

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Re: Quad approved
« Reply #26 on: August 30, 2012, 11:01:43 AM »
So if the US had a NHS style price structure for pharmaceuticals how would effect the prices the UK pays?

It wouldn't make a difference.
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Miss Philicia

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Re: Quad approved
« Reply #27 on: August 30, 2012, 11:04:02 AM »
It wouldn't make a difference.

link, please
"Iíve slept with enough men to know that Iím not gay"

Offline newt

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Re: Quad approved
« Reply #28 on: August 30, 2012, 01:17:47 PM »
Atripla US annual wholesale cost $21,000, UK in your money $11-12,000 (£7,500). There is no link. The pricing systems are different. We pay less for the same drugs as you and pharma still makes a decent profit. Since the Quad has no special resistance busting qualities and costs a shed load more than other as-good-as 1 x day options  I expect to see very few people on it in the UK.

- matt
"The object is to be a well patient, not a good patient"

Offline Valmont

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Re: Quad approved
« Reply #29 on: August 30, 2012, 04:18:54 PM »
I donīt know how big pharmas work...  Viraday (eq. to Atripla) is around USD 360 for 30 tablets here and the 2 Indian tablets regime our health system give us should be much cheaper because they donīt buy Viraday because of its cost, my doc says...

Side effects seem the same........

For me, Iīm good with 2 tablets once a day...

I understand pharma corps earn money, but it has not to be done with a high cost for the states or for the people...  Many problem we have with insurance (and work, and getting money from the bank and so on...) are because of these prices and sometimes, I think it is better to be living in a middle or low income state, with a responible health policy than in the "First World"

Are those prices fair???
Apr 2011: Diagnotized
Jun 2011: CD4: 504  VL: 176.000
Dic 2011: CD4: 714  VL: 95.000
May 2012: CD4: 395 VL: 67.000
Jun 2012: CD4: 367
Agu 2012: Starting Emtricitabine 200 mg / Tenofovir 300 mg and Efavirenz 600 mg (2 pills) different brands or VIRADAY
Sep 2012: VL: 138
Dic 2012: CD4: 708 VL: <34  %CD4: 32%
Jan 2013: CD4: 707 VL: <20
May 2013: CD4: 945 VL: <34 %CD4: 33%
Agu 2013: CD4: 636 VL: <34 %CD4: 50% (is that possible?)

Offline buginme2

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Re: Quad approved
« Reply #30 on: August 30, 2012, 05:52:29 PM »
Drug companies could lower the prices they charge in the United States.   Understand, doing so would cause prices to rise for the rest of the world.  Low drug prices in the UK, Europe, and the third world are offset by high prices here.

Your welcome.
"All I need are some tasty waves, a cool buzz, and I'm fine."

http://www.youtube.com/watch?v=6e0gcEC1TWE

 


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