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Author Topic: Humanized Mouse: Drug Efficacy, HIV transmission, and Latency  (Read 1149 times)

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Offline Jmarksto

  • Member
  • Posts: 479
Humanized Mouse: Drug Efficacy, HIV transmission, and Latency
« on: August 04, 2012, 12:59:20 PM »
This is the best article I have seen on some of the preliminary research, and potential, with the mouse with a human immune system.

http://tinyurl.com/blrx4jv

The article talks about using the mice to test HIV drug efficacy, transmission rates, and latency.  Here are a few, brief highlights - there is much more in the full article:

They surgically implanted tiny pieces of human liver and thymus tissue under the kidneys of mice that were genetically immune deficient the mice didnt have B cells and were missing thymuses, the organ that produces T cells. Then the team transplanted human hematopoietic stem cells into the mices bone marrow. In a few days, each mouse started generating an entirely new thymus.

Human lymphoid cells including T cells and B cells had populated the large and small intestines. And there they were. This was a huge surprise to everyone in the field.

By using humanized mice, scientists can search for ways to drive the virus out of latency in a living organism.

This is our charter: to cure a mouse under any circumstances and then translate that into humans.
03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45%  VL 25
02/25/14 CD4   792/37%  VL UD
07/09/14 CD4 1004/39%   VL UD

Offline Common_ground

  • Member
  • Posts: 288
Re: Humanized Mouse: Drug Efficacy, HIV transmission, and Latency
« Reply #1 on: August 04, 2012, 01:19:33 PM »
Reading this I'm surprised they haven't found a cure yet. :o Humanized mice sounds like its year 3000 or something  ;D

Joking aside, cool article, hoping for more progress.
2011 May - Neg.
2012 June CD4:205, 16% VL:2676 Start Truvada/Stocrin
2012 July  CD4:234, 18% VL:88
2012 Sep  CD4:238, 17% VL:UD
2013 Feb  CD4:257, 24% VL:UD -viramune/truvada
2013 May CD4:276, 26% VL:UD

Offline Jmarksto

  • Member
  • Posts: 479
Re: Humanized Mouse: Drug Efficacy, HIV transmission, and Latency
« Reply #2 on: August 04, 2012, 01:42:13 PM »
Reading this I'm surprised they haven't found a cure yet. :o Humanized mice sounds like its year 3000 or something  ;D

Joking aside, cool article, hoping for more progress.


Here's to getting to year 3000 faster than having to wait it out...

I think they have made significant progress on this in the last year or so.  This should speed the research up quite a bit - one challenge as noted in the article is that the mice can't reproduce with human immune systems, the need to be "manufactured" individually.
03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45%  VL 25
02/25/14 CD4   792/37%  VL UD
07/09/14 CD4 1004/39%   VL UD

 


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