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Author Topic: NIH Scientists Identify New HIV-Suppressing Protein in the Blood of HIV+  (Read 1839 times)

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Offline John2038

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Sources:
http://aidsinfo.nih.gov/e-news/archive/2012/6/1
http://www.pnas.org/content/109/24/9569.short

“Scientists have identified a new HIV-suppressing protein in the blood of people infected with the virus. In laboratory studies, the protein, called CXCL4 or PF-4, binds to HIV such that it cannot attach to or enter a human cell. The research was led by Paolo Lusso, M.D., Ph.D., chief of the Section of Viral Pathogenesis in the Laboratory of Immunoregulation at the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH.

“CXCL4 belongs to a family of molecules called chemokines that help regulate the movement of immune cells around the body. In the mid-1990s, four chemokines—three discovered by Dr. Lusso, Robert Gallo, M.D., and their colleagues—were found in laboratory experiments to function as HIV inhibitors. These chemokines as well as CXCL4 may regulate the level of virus replication in infected individuals and thus the pace at which HIV disease progresses.

“According to Dr. Lusso, the site where CXCL4 binds to the outer coat of HIV seems to be different from other known vulnerable sites targeted by HIV-blocking antibodies and drugs. His team is working with scientists at the NIAID Vaccine Research Center to define the atomic-level crystal structure of this binding site, which potentially may play a role in the future development of HIV treatments or vaccines.” 


EDIT: Article replaced with the NIH abstract
« Last Edit: June 25, 2012, 02:53:55 AM by John2038 »

Offline J220

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I'm a bit confused, is the text you wrote a direct quote from the article(s) listed as sources, or your own interpretation? Reason I ask is because some of the statements on the post (e,g, "they believe a cure can be found in the form of a HIV vaccine", "major breakthrough", "research holds great importance") seem like rather liberal extrapolations of the data presented in the articles, I couldn't find those particular statements in the articles you linked.
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline John2038

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Hi,

You are right J220. My initial post is referring to this article.

I thought having copied another article.
I try to read a same research news from different websites. Consequently, I may have as a result a couple of windows open for a same research news, so my mistake.
 
I will correct my initial post to reflect the NIH article, instead of the other one, which is a you said "rather liberal extrapolations" -fully agreed. Thanks for your comment.

Cheers,
John
« Last Edit: June 25, 2012, 02:56:39 AM by John2038 »

Offline J220

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Thanks for the clarification. Yes, that other article was a little weird as written. Went through other articles on that site and it seems to be one of those "revenue generator" websites, loaded with ad links. Seems they're everywhere these days.

Your other links and the article itself are excellent though, thanks for posting.

J.
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

 


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