Quantcast

Subscribe to:
POZ magazine
Newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr Instagram
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
October 31, 2014, 01:02:02 AM

Login with username, password and session length


Members
Stats
  • Total Posts: 644110
  • Total Topics: 49024
  • Online Today: 162
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online
Users: 3
Guests: 126
Total: 129

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: 05/2012: Started reservoir reduction study  (Read 1175 times)

0 Members and 1 Guest are viewing this topic.

Offline eric48

  • Member
  • Posts: 1,192
  • @HIVPharmaCure & tinyurl.com/HIVPharmaCure
05/2012: Started reservoir reduction study
« on: June 17, 2012, 05:40:15 PM »
05/2012: Started reservoir reduction study

Manhattan Project: a reservoir reduction proof of concept study
***********************************************

Hi,

Starting May 2012, I have joined a prospective proof of concept study for a molecule aimed at HIV reservoir eradication.

This thread is being opened to provide as much patient testimony as I am allowed to.

My treatment history can be viewed at :
http://forums.poz.com/index.php?topic=33062.0

As of today, they are no large clinical trial of interest to me in my area, I have therefore joined this small scale study.

After a certain delay in being accepted and being explained the nature of the study, aka the intervention, I have had to sign a informed consent form, which was easy enough...

On top of that I had to sign a 20 or more pages of confidentiality agreement which states what information about the outcome and the procedure I am entitled to receive and/or make public.
In other words, should the proof of concept, be successfull, there are many further legal steps (patents, publications, etc.) that do require to be protected. That was kind of unexpected

Because of the design of the experiment, there is no need for a control group, so I am in the intervention arm, so to speak.

The intervention started mid of may with a preliminary safety induction, which went well.

The initial dosage was very small (or so we thought) and no effect was seen.

The intervention, per se, is scheduled to start in the summer. The aim is to 'reactivate' the latent CD4 reservoir and see if it can be decreased.

One of the reasons I could enter this study is that I had been infected recently and treated early enough (less that one year post infection).
Duration of treatment had to be small at enrollment. it is expected that the immune system may have remained active enough to go after CD4s that may be awaken from their latency

End of may, I got my second safety induction.
Apparently, it lead to an early immune system response that was not expected at that dosage...

But, so far so good

I'd like to share patient experience with others undergoing these type of studies, especially if this is something they feeled from within their body as well as the emotional aspects.

Cheers

Eric
« Last Edit: June 18, 2012, 02:10:03 AM by eric48 »
NVP/ABC/3TC/... UD; CD4 > 1000; CD4/CD8 ~ 2.0   safety stock : 3 months (2013: FOTO= 5d. ON 2d. OFF)

Offline xman

  • Member
  • Posts: 288
Re: 05/2012: Started reservoir reduction trial
« Reply #1 on: June 17, 2012, 09:03:03 PM »
please provide a link that explains in detail the trial.
sign the petition launched by the aids policy project addressed to the nih aimed to increase the money needed to find the cure:

http://www.aidspolicyproject.org/petition_for_the_nih

we can make a difference and we need to fight. please support them! it doesn't cost you anything. they need it now more than ever!

Offline Ann

  • Administrator
  • Member
  • Posts: 28,140
  • It just is, OK?
    • Num is sum qui mentiar tibi?
Re: 05/2012: Started reservoir reduction study
« Reply #2 on: June 18, 2012, 08:12:01 AM »
please provide a link that explains in detail the trial.

Yes, Eric. You should be able to google the title of the study and get something. I googled the title you suggest, but I have a feeling it's not the title that would appear at the top of any of the literature or papers you have been given (or signed) because it's not coming back with anything when placed in quotes.

My partner has taken part in a study recently and I was able to get results using the title at the top of one of the pages he was given, so I know it's possible.

If you plan on discussing your experiences with the trial, it would be useful to at least have some of the official information on it. Thanks.
« Last Edit: June 18, 2012, 08:14:34 AM by Ann »
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.