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Author Topic: Article on micronutrients  (Read 2945 times)

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Offline lydgate

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  • Posts: 1,022
  • Virgin, can't drive
Article on micronutrients
« on: September 30, 2006, 12:52:41 PM »
Micronutrient Supplementation Increases CD4 Count in HIV-Infected Individuals on Highly Active Antiretroviral Therapy: A Prospective, Double-Blinded, Placebo-Controlled Trial
Posted 09/14/2006

Jon D. Kaiser, MD; Adriana M. Campa, PhD; Joseph P. Ondercin, PA-C; Gifford S. Leoung, MD; Richard F. Pless, PhD; Marianna K. Baum, PhD 

Abstract and Introduction
Abstract
Objective: To examine the immunologic, metabolic, and clinical effects of broad spectrum micronutrient supplementation in HIV-infected patients taking highly active antiretroviral therapy (HAART).
Design: A prospective, randomized, double-blinded, placebo-controlled trial.
Methods: Forty HIV-infected patients taking a stavudine and/or didanosine-based HAART regimen were prospectively randomized to receive micronutrients or placebo twice daily for 12 weeks. Data were collected at 4-week intervals including immunologic, metabolic, and clinical measurements. The study examined the effect of micronutrient supplementation on immunologic parameters as the primary end point. The secondary end points were metabolic and clinical effects and distal symmetrical polyneuropathy.
Results: The mean absolute CD4 count increased by an average of 65 cells in the micronutrient group versus a 6-cell decline in the placebo group at 12 weeks (P = 0.029). The absolute CD4 count increased by an average of 24% in the micronutrient group versus a 0% change in the placebo group (P = 0.01). The mean HIV-1 RNA decreased in the micronutrient supplementation group, although not significantly. Neuropathy scores improved in the micronutrient group by 42% compared with a 33% improvement in the placebo arm. This difference did not reach statistical significance. Fasting serum glucose, insulin, and lipids were not adversely affected in the patients taking the micronutrients.
Conclusions: Micronutrient supplementation can significantly improve CD4 cell count reconstitution in HIV-infected patients taking HAART. The micronutrient supplement tested was well tolerated and may hold promise as an adjuvant therapy in the treatment of HIV. Further investigation is warranted.

Her finely-touched spirit had still its fine issues, though they were not widely visible. Her full nature, like that river of which Cyrus broke the strength, spent itself in channels which had no great name on the earth. But the effect of her being on those around her was incalculably diffusive: for the growing good of the world is partly dependent on unhistoric acts; and that things are not so ill with you and me as they might have been, is half owing to the number who lived faithfully a hidden life, and rest in unvisited tombs.

George Eliot, Middlemarch, final paragraph

Offline Ann

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    • Num is sum qui mentiar tibi?
Re: Article on micronutrients
« Reply #1 on: September 30, 2006, 02:39:03 PM »
Quote
Conclusions: Micronutrient supplementation can significantly improve CD4 cell count reconstitution in HIV-infected patients taking HAART. The micronutrient supplement tested was well tolerated and may hold promise as an adjuvant therapy in the treatment of HIV. Further investigation is warranted.

It really wicks me off that these types of studies always seem to be "in patients taking HAART". Why do they never do studies on people NOT yet on HAART? I'd like to see some conclusions as to whether or not nutrition has any bearing on being able to maintain without HAART. I'm not discounting the importance of studies for people who are already on the meds, but what about the rest of us already?

Just ranting. ::)

Ann

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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline J.R.E.

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  • Posts: 7,221
  • Joined Dec-2003 Living positive, since 1985.
Re: Article on micronutrients
« Reply #2 on: September 30, 2006, 03:30:00 PM »
Lydgate,

Thanks for that article. here is the direct lnk to that article, for those interested :

http://www.medscape.com/viewarticle/543573


Sorry : you will have to register to read the article ....It's through Medscape...


Ray
« Last Edit: September 30, 2006, 03:33:01 PM by J.R.E. »
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 12.5mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


 In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started my first  HAART regimen  on October 24th,03.

 As of 8/2514,  t-cells are at 402, Viral load <40

 Current % is at 11%

  
 62 years young.

Offline alisenjafi

  • Member
  • Posts: 811
  • They say HIV comes from monkeys!
Re: Article on micronutrients
« Reply #3 on: September 30, 2006, 04:49:42 PM »
Hey that's why I recommended bee pollen- chock full o' the stuff!
"You shut your mouth
how can you say
I go about things the wrong way
I am human and I need to be loved
just like everybody else does"
The Smiths

 


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